Virtual Issue Reversible Tyrosine Phosphorylation Signalling and Disease

May 2010

Papers Selected by Nicholas K. Tonks

Front cover: Figure 2 from L. Tabernero et al. (2008) FEBS J 275: 867-882.

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Introduction

This year marks the 30th anniversary of the first reports of the phosphorylation of tyrosyl residues in proteins involved in signal transduction by Tony Hunter and his colleagues [1, 2]. Developments from this groundbreaking discovery have revealed remarkable insights into the regulation of signal transduction in response to growth factors, hormones and cytokines. Furthermore, our understanding of how such signalling events are disrupted in disease has provided the foundation for new therapeutic strategies that are at the core of current approaches to treating major diseases, such as cancer. Although the focus of research was originally on the kinases, the first characterization of the protein tyrosine phosphatases (PTPs) as a novel class of signalling enzymes over 20 years ago [3, 4] helped to establish that the coordinated regulation of the activities of both protein tyrosine kinases (PTKs) and phosphatases lies at the heart of control over signal transduction. Although to a certain extent there remain kinase and phosphatase camps, such a categorization of research is somewhat artificial. Nowadays we are in the fortunate position of being able to study the fundamental importance of reversible phosphorylation, using kinases and phosphatases as complementary perspectives from which to address major problems in biology. In this Virtual Issue of FEBS Journal, I have selected some of the reviews and primary papers that have been published on this area of research in the journal since 2007. They cover various aspects of the importance of reversible tyrosine phosphorylation, and the regulation of protein tyrosine kinases and phosphatases, as well as the application of this knowledge to new approaches to therapeutic intervention. The Editorial Board of FEBS Journal encourages submission of more manuscripts in this area.

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References

1. Hunter, T. and Sefton, B.M. (1980) Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc. Natl. Acad. Sci. USA 77: 1311-1315.

2. Sefton, B.M., Hunter, T., Beemon, K. and Eckhart, W. (1980) Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell 20: 807-816.

3. Tonks, N.K., Diltz, C.D. and Fischer, E.H. (1988) Purification of the major protein tyrosine phosphatases of human placenta. J. Biol. Chem. 263: 6722-6730.

4. Tonks, N.K., Diltz, C.D. and Fischer, E.H. (1988) Characterization of the major protein tyrosine phosphatases of human placenta. J. Biol. Chem. 263: 6731-6737.

Review Articles

• Protein tyrosine phosphatases: functional inferences from mouse models and human diseases
  Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch, Andrew W. Stoker
  FEBS Journal Volume 275, Issue 5, March 2008, Pages: 816-30

• Protein tyrosine phosphatases: regulatory mechanisms
  Jeroen den Hertog, Arne Östman, Frank-D. Böhmer
  FEBS Journal Volume 275, Issue 5, March 2008, Pages: 831-47

• Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease
  Rafael Pulido and Rob H. van Huijsduijnen
  FEBS Journal Volume 275, Issue 5, March 2008, Pages: 848-66

• Protein tyrosine phosphatases: structure–function relationships
  Lydia Tabernero, A. Radu Aricescu, E. Yvonne Jones, Stefan E. Szedlacsek
  FEBS Journal Volume 275, Issue 5, March 2008, Pages: 867-82

• Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer
  Tetsuya Mitsudomi, Yasushi Yatabe
  FEBS Journal Volume 277, Issue 2, January 2010, Pages: 301-08

• Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy
  Isamu Okamoto
  FEBS Journal Volume 277, Issue 2, January 2010, Pages: 309-15

• EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors
  Kenji Takeuchi, Fumiaki Ito
  FEBS Journal Volume 277, Issue 2, January 2010, Pages: 316-26

• Human anti-ErbB2 immunoagents – immunoRNases and compact antibodies
  Claudia De Lorenzo, Giuseppe D'Alessio
  FEBS Journal Volume 276, Issue 6, March 2009, Pages: 1527-35

• Calmodulin-mediated regulation of the epidermal growth factor receptor
  Pablo Sánchez-González, Karim Jellali, Antonio Villalobo
  FEBS Journal Volume 277, Issue 2, January 2010, Pages: 327-42

• A decade of Cdc14 – a personal perspective
  Angelika Amon
  FEBS Journal Volume 275, Issue 23, December 2008, Pages: 5774-84
  
  

Original Articles

• Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase
  Kenji Takeuchi, Tomohiro Shin-ya, Kazuto Nishio, Fumiaki Ito
  FEBS Journal Volume 276, Issue 5, March 2009, Pages: 1255-65
  

• Mutation of epidermal growth factor receptor is associated with MIG6 expression
  Takeshi Nagashima, Ryoko Ushikoshi-Nakayama, Atsushi Suenaga, Kaori Ide, Noriko Yumoto, Yoshimi Naruo, Kaoru Takahashi, Yuko Saeki, Makoto Taiji, Hiroshi Tanaka, Shih-Feng Tsai, Mariko Hatakeyama
  FEBS Journal Volume 276, Issue 18, September 2009, Pages: 5239-51
  

• Differential binding of human immunoagents and Herceptin to the ErbB2 receptor
  Fulvia Troise, Valeria Cafaro, Concetta Giancola, Giuseppe D'Alessio, Claudia De Lorenzo
  FEBS Journal Volume 275, Issue 20, October 2008, Pages: 4967-79
  

• The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor (274, p 3078-3093)
  Jacky Bonaventure, Linda Gibbs, William C. Horne, Roland Baron

• The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1
  Marie K. Inder, Lyn M. Wise, Stephen B. Fleming, Andrew A. Mercer
  FEBS Journal Volume 275, Issue 1, January 2008, Pages: 207-17
  

• FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis
  Ju-Eun Ha, Young-Eun Choi, Jinah Jang, Cheol-Hee Yoon, Ho-Youn Kim, Yong-Soo Bae
  FEBS Journal Volume 275, Issue 14, July 2008, Pages: 3546-55

• Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle
  Nikolai P. Kaimachnikov, Boris N. Kholodenko
  FEBS Journal Volume 276, Issue 15, August 2009, Pages: 4102-118
  

• Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase α is required for Src activation
  Andrei M. Vacaru, Jeroen den Hertog
  FEBS Journal Volume 277, Issue 6, March 2010, Pages: 1562-70

• Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases
  Nicholas G. Martin, Peter C. McAndrew, Paul D. Eve, Michelle D. Garrett
  FEBS Journal Volume 275, Issue 12, June 2008, Pages: 3099-109

• NF-κB regulates the transcription of protein tyrosine kinase Tec
  Liang Yu, Oscar E. Simonson, Abdalla J. Mohamed, C. I. Edvard Smith
  FEBS Journal Volume 276, Issue 22, November 2009, Pages: 6714-24

• Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity
  Silje A. Solheim, Evangelia Petsalaki, Anne J. Stokka, Robert B. Russell, Kjetil Taskén, Torunn Berge
  FEBS Journal Volume 275, Issue 19, October 2008, Pages: 4863-74
  

• Differential membrane compartmentalization of Ret by PTB-adaptor engagement
  T. K. Lundgren, Moritz Luebke, Anna Stenqvist, Patrik Ernfors
  FEBS Journal Volume 275, Issue 9, May 2008, Pages: 2055-66

• Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7 (274, p 96-108)
  Gönül Dilaver, Rinske van de Vorstenbosch, Céline Tárrega, Pablo Ríos, Rafael Pulido, Karlijn van Aerde, Jack Fransen, Wiljan Hendriks
  FEBS Journal Volume 274, Issue 1, January 2007, Pages: 96-108
  

• Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells
  Yi-Wei Lou, Yi-Yun Chen, Shu-Fan Hsu, Ren-Kun Chen, Chih-Lei Lee, Kay-Hooi Khoo, Nicholas K. Tonks, Tzu-Ching Meng
  FEBS Journal Volume 275, Issue 1, January 2008, Pages: 69-88

• Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B
  Antje Trümpler, Bernhard Schlott, Peter Herrlich, Peter A. Greer, Frank-D. Böhmer
  FEBS Journal Volume 276, Issue 19, October 2009, Pages: 5622-33

• Redox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPα, LAR, RPTPµ and CD45
  Arnoud Groen, John Overvoorde, Thea van der Wijk, Jeroen den Hertog
  FEBS Journal Volume 275, Issue 10, May 2008, Pages: 2597-2604

• DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
  Anne Seifert, Lindsey A. Allan, Paul R. Clarke
  FEBS Journal Volume 275, Issue 24, December 2008, Pages: 6268-80

• Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation
  Nora Göckler, Guillermo Jofre, Chrisovalantis Papadopoulos, Ulf Soppa, Francisco J. Tejedor, Walter Becker
  FEBS Journal Volume 276, Issue 21, November 2009, Pages: 6324-37
  

• Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis
  Ulla Schwertassek, Deirdre A. Buckley, Chong-Feng Xu, Andrew J. Lindsay, Mary W. McCaffrey, Thomas A. Neubert and Nicholas K. Tonks
  FEBS Journal Volume 277, Issue 11, June 2010, Pages: 2463-73

• Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays
  Neil Warner, Leanne E. Wybenga-Groot, Tony Pawson
  FEBS Journal Volume 275, Issue 10, May 2008, Pages: 2561-73
  

• Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases
  Tara L. Davis, John R. Walker, Abdellah Allali-Hassani, Sirlester A. Parker, Benjamin E. Turk, Sirano Dhe-Paganon
  FEBS Journal Volume 276, Issue 16, August 2009, Pages: 4395-404

• Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells
  Kazuya Terasawa, Atsuhiko Ichimura, Fumiaki Sato, Kazuharu Shimizu, Gozoh Tsujimoto
  FEBS Journal Volume 276, Issue 12, June 2009, Pages: 3269-76

• Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer
  Guofu Wang, Weimin Mao, Shu Zheng, Jingjia Ye
  FEBS Journal Volume 276, Issue 19, October 2009, Pages: 5571-78
  

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