Basic & Clinical Pharmacology & Toxicology

Cover image for Vol. 119 Issue 6

Edited By: Kim Brøsen

Impact Factor: 3.097

ISI Journal Citation Reports © Ranking: 2015: 24/89 (Toxicology); 71/253 (Pharmacology & Pharmacy)

Online ISSN: 1742-7843

Author Guidelines

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.

Authors are invited to consult our editorial policy on publication ethics statement here.

Manuscripts written in the English language should be submitted online to

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript will be checked for plagiarism against previously published works.

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the copyright transfer agreement

If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:

CTA Terms and Conditions

For authors choosing OnlineOpen

If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution Non-Commercial License OAA

Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

For RCUK and Wellcome Trust authors click on the link below to preview the terms and conditions of this license:

Creative Commons Attribution License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit

OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. See the full list of terms and conditions. 

Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website here. Prior to acceptance, there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

WORD 2007
Authors, please note that docx files are compatible with journal production systems.

No responsibility is assumed by the journal for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material published herein.

Studies involving human beings must be conducted in accordance with the Declaration of Helsinki and guidelines on Good Clinical Practice.
For the humane use and care of experimental animals, internationally accepted principles must be observed. The ethical standards in Directive 86/609/EEC, ''European Convention for the Protection of Vertebrate Animals Used for Experimental and other Scientific Purposes'', 1986, and the ''Guiding Principles in the Use of Animals in Toxicology'', adopted by the Society of Toxicology in 1989, for the acceptable use of experimental animals, must be adhered to. In general, manuscripts in which animals are used without reasonable respect to their lives and sufferings will not be accepted. Live experimental animals should only be used, if similar results can not be obtained by alternative methods, e.g. in vitro methods.

The politics of BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY regarding conflict of interest and sources of funding complies with the ''Uniform Requirements for Manuscripts Submitted to Biomedical Journals'' ( Thus, a conflict of interest exists if an author, reviewer or an editor handling any given manuscript has ties that could influence his or her judgement in an inappropriate manner. This could typically be financial ties with industry either directly or indirectly via family in the form of research funding, employment, consultancies, stock ownership, honoraria or expert testimony. Other sources of conflict of interest could be personal relationships, academic competition and intellectual passion. Authors submitting a manuscript to BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY are required to disclose any conflict of interest. ALL contributing authors are required to sign the ICMJE Conflict of Interest Form and provide a copy to the corresponding author prior to submission of their manuscript. The corresponding author must subsequently compile a full Disclosure Statement that accurately reflects what each author has disclosed and include this Disclosure Statement on the Title Page of the Main Document. It is the corresponding author's responsibility to store the ICMJE forms and to provide them to the Editorial Office if requested at any time. Do not send these forms to the Editorial Office and do not upload them to ManuscriptManager unless requested. The Editors will abstain from participation in the peer review process and editorial handling of a manuscript if a conflict of interest exists, and the same applies for the reviewers.

The ICMJE conflict of interest disclosure form can be found here.

This journal works together with the Open Access journal Pharmacology Research & Perspectives (PR&P) to enable rapid publication of good quality research that is unable to be accepted for publication by our journal. Authors may be offered the option of having the paper, along with any related peer reviews, transferred for consideration by the Editor of PR&P. Authors are requested to revise their manuscript according to reviews, then submit to PR&P for a publication decision to be made a short time after the transfer takes place. The Editor of PR&P will accept submissions that report well-conducted research which reaches the standard acceptable for publication. PR&P is a Wiley Open Access journal and article publication fees apply. For more information, please go to PR&P's homepage

Manuscripts should be submitted in the English language (see the Language paragraph below), double-spaced with a wide margin and pages should be numbered consecutively. They should be submitted as only ONE Word file including all text, and with tables and figures at the end. Please do not upload separate files with tables and figures!

Title page
This should contain a concise title, institution(s) or laboratory(ies) where the work was done (in English), names of all authors with first names spelled out, and an abbreviated form of the title (running title). Full mailing address in English for the corresponding author should also be given, including e-mail address.

Page 2
This should contain an abstract of up to 250 words. The abstract should contain a summary of what was done, the results obtained, and valid conclusions drawn therefrom. The abstract text should not include any subheadings!

Main text
The following pages should contain Introduction and background (long historical introductions should be avoided, a reference to bibliographies in handbooks or the like will suffice), followed by Materials and Methods, Results, Discussion which should incorporate the conclusion(s) drawn from the study, Acknowledgements and References. Do not use numbered headings or subheadings in any section. Numbered tables with legends, illustrations or graphs in high quality with legends should be on separate pages at the end of the manuscript document. Abbreviations should be kept to an absolute minimum.

Abbreviations in tables and figures should be explained in the legends. Text and footnotes must contain all the information necessary to understand and interpret the table without reference to the text. Illustrations must be clear enough to permit readable reproduction. Symbols should be large enough to be readable also after reduction of the illustration.

The experimental results should on the whole be published only in the form of graphs or tables, which must contain all the information necessary to understand the table or illustration without reference to the text.

Tables. Each table should have a brief, specific, descriptive title, giving sufficient explanation to make the data intelligible without reference to the text. Number all tables and cite in numerical order in the text, using Arabic numerals.

Preparation of figures. Cite figures in the text in numerical order using Arabic numerals. For peer-review submission, follow the online uploading instructions. Please save vector graphics (e.g. line artwork) in Encapsulated Postscript Format (EPS) and bitmap files (e.g. half-tones) in Tagged Image File Format (TIFF). Ideally, vector graphics that have been saved in metafile (.WMF) or pict (.PCT) format should be embedded within the body of the text file. More information on electronic artwork can be found at

Figure sizing for accepted manuscripts. For the print publication, lay out figures as compactly as is consistent with conveying the relevant data. Figures will be sized to fit the smallest possible space, but in order to prevent radical changes in figure content, prepare the figures in one of two sizes: 8.0 cm (1-column width) or, if necessary, 11.5 cm (11/2 column width). These instructions do not apply to figures submitted for online review and prepublication.

Figure legends. All legends must begin with a short descriptive sentence that sums up the intent and content of the data contained in the figure. This sentence should be in boldfont. A more detailed explanation of the data contained in the figure and/or its parts should follow. The detailed description should be in Roman type (ie, not in boldfont).

For queries, please contact the production editor at

Cover Art
After your article has been accepted, you may have a figure or other illustration which is representative of your article considered for possible inclusion on the monthly online journal cover. Please follow the instructions below and send your cover artwork to the Editorial Office no later than 10 days after acceptance.

Select your figure or illustration. You may modify the figure with colour or other enhancements. The figure should illustrate your work but does not have to be a figure that is exatly the same as it appears in the article. Submitted figures should be in full colour but exceptional black and white figures will be considered as well. Graphs and charts will not generally be considered for the cover. Please also submit a descriptive text along with the figure. This should at a minimum be the figure legend, article title, BCPT manuscript number and author names. Send the artwork to Editorial Manager Henrik Horneberg at

The Editor will select among the submitted figures. You will not be informed if your figure is not selected.

References must be cited according to the Vancouver system (
Basic & Clinical Pharmacology & Toxicology deviates from icmje in the following respects: No full stop after the abbreviated name of the journal  

  • As journals paginate consecutively, issue number is not used; only volume and page number.

Journal names should be abbreviated according to the system used in Index Medicus (Pubmed Service ”Journals Database”).
Number the references consecutively in the order they appear for the first time in the text. References that are cited in table or figure texts should be numbered in accordance with the first appearance of the table or figure in question. References in the text must be cited with the appropriate number in square bracket. In case of more than one reference in one square bracket, the numbers must be separated by a comma, e.g. [3, 4, 8]; In case of more than two consecutive reference numbers, use hyphen, e.g. [6-9];

Avoid abstracts and meeting proceedings as references; unpublished observations and personal communications must not be used as references. Accepted manuscripts that have not yet been published may appear in the reference list. Indicate journal name and year in question followed by “in press” in brackets. Articles published online are identified by their DOI (Digital Object Identifier System) reference ( Electronic material is cited like other literature.

In general, references must be written as follows

Surname followed by initial(s) without comma or full stop; then comma before the next author’s surname followed by his/her initial(s): Larsen JT, Brøsen K.
If there are more than six authors, et al after the sixth author’s initial(s) should be added:
Smith PJ, Byron AM, Jones E, Andersson C, Tucker AD, Rowland P et al.
Put a full stop after the last author’s initials (or after et al), and before the article/monography title etc.
The title should be written with initial capital while all other words are in small letters, unless it is a matter of nationalities (in a Swedish population) or names of e.g. commissions and the like. As a rule, continue with small letters after colon. Do not include sub-title.
The journal name should be written with ordinary font (no italics); do not put full stops between the individual parts of the abbreviation or between the journal name and year: Basic Clin Pharmacol Toxicol 2005.
Year, volume number and pages should be written without space.
Put a semicolon between year and volume number and colon between volume number and page number: BMJ 2004;329:1233-6.

Examples of correctly written references

Journal article
Brøsen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem Pharmacol 1993;45:1211-4.
Rasmussen SG, Gether U. Purification and fluorescent labelling of the human serotonin transporter  Biochemistry 2005;44:3494-505.

Book chapter
Zanger UM, Eichelbaum M. CYP2D6. In: Levy RH, Thummel KE, Trager WF, Hansten PD, Eichelbaum M (eds). Metabolic Drug Interactions. Lippincott Williams & Willis Philadelphia PA 2002;87-94.

DOI reference
Masmanian SK, Thon-That H, Schneewind O. Sortase catalysed anchoring of surface proteins to the cell wall of Stapylococcus aureus. Mol Microbiol 2001;40:1049-1057.

Doi: 10.1046/j. 1365-2958.2001.02411.x

Internet reference /March 2006

We recommend the use of a tool such as Reference Manager for reference management and formatting. Reference Manager reference styles can be searched for here:

Supporting Information
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY gives authors the opportunity to include data online that would be inappropriate or impractical to include in the printed version. These data may substantially enhance the importance of the research and may also be of benefit to readers. Authors are encouraged to include data such as 3-D structures/images, large tables and any other supporting data too large for print publication. All supporting information must be submitted as 'supplementary files for review' with the original manuscript via ScholarOne Manuscripts. 'Supporting Information' will be made available alongside the online version (only) of the published article. Please note that supporting information will not be copy-edited or typeset, but be made available online in exactly the form it is received and approved. Supporting information guidelines including acceptable file formats and sizes are available here

The manuscript should be written in a concise and clear British English language. Some linguistic in-house correction is performed, however, a manuscript may be returned to the authors for major linguistic revision and rewriting. The authors have the full responsibility for the English language and the style of the manuscript. The manuscript will be edited according to the style of the journal, and the proofs must be read carefully by the author.

The international nomenclature should be used. Chemical formulae should as far as possible be written on one line. If proprietary names are used, the chemical constitution or, if this is not known, the outline of the preparation must appear clearly in the text. When available, INN-names should be used.
Only officially accepted abbreviations and abbreviations of long chemical names etc. should be used. Unnecessary abbreviations impede the reading of a paper; therefore the number of abbreviations should be kept at an absolute minimum. Necessary abbreviations should be used with consistency and defined at first mention. Abbreviations should not be used in the title of the paper and in the running title.

Authors will be charged GBP 150 for each page in the final published version exceeding 6 typeset pages, although for ''Short Communications'' GBP 150 for each page exceeding 2 typeset pages. Page charge does not apply to MiniReviews. As a rule of thumb, an average text page in the typeset page (without figures and tables) is approximately 900 words.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY will accept ''Short Communications'' for rapid publication of important experimental results and short preliminary results. The length of the manuscript should not exceed 2 printed pages including title, general text, presentation of experimental results without headings, either table or figure, and references. The general rules for manuscripts published in BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY should be followed. No abstract is necessary. Authors will be charged for pages in excess of 2 printed pages, according to the above Page charge paragraph.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY accepts both invited and spontaneous MiniReviews, which will be peer-reviewed and should conform to the form and style of the journal. MiniReviews should be up to 8 printed pages including a maximum of 50 references. If invited, please indicate in the cover letter the name of the person you were invited by.

Letters to the Editor may contain essential corrections and comments to articles published in the journal. Letters to the Editor will be published without delay after acceptance. Annotations & Reflections concerning important developments within the publication scope of the journal will be accepted by the Editor. Annotations & Reflections should not exceed 6 printed pages.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY will publish supplements, consisting of e.g. monographs, abstracts or papers from a congress or a symposium, articles or a series of articles or a doctorate thesis. The publication of the supplement should be approved by the journal, and the authors or organizers will be responsible for all production and mailing costs, unless otherwise agreed. After approval, the supplements are not subject to revision by the Editorial Office. The quality of language must meet the standards maintained by the journal, and all the above-mentioned instructions should be followed. Supplements are delivered free of charge to the subscribers of the journal.
Further information and cost estimates may be obtained from the Editorial Office.

The corresponding author will be provided with a free PDF file of the article.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY will accept for publication announcements of interest to pharmacologists and toxicologists (the readers), such as notices of congresses, society meetings, symposia, awards, or other matters. 

Note to NIH Grantees

Pursuant to NIH mandate, Wiley will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance.  This accepted version will be made publicly available 12 months after publication.  For further information, see