Chemical Biology & Drug Design

Cover image for Vol. 81 Issue 5

Edited By: David Selwood

Impact Factor: 2.282

ISI Journal Citation Reports © Ranking: 2011: 30/59 (Chemistry Medicinal); 182/290 (Biochemistry & Molecular Biology)

Online ISSN: 1747-0285

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• Rapid review and publishing: 30 days on average from submission to first decision. We discourage reviewers from requesting “additional experiments”.
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Recently Published Articles

  1. Synthesis, characterisation and biological evaluation of 99mTc(CO)3 labeled peptides for potential use as tumor targeted radiopharmaceuticals

    Rinku Baishya, Dipak Kumar Nayak, Nabanita Chatterjee, Kamal Krishna Halder, Sanmoy Karmakar and Mita Chatterjee Debnath

    Accepted manuscript online: 17 MAY 2013 04:25AM EST | DOI: 10.1111/cbdd.12166

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    Three linear peptides were synthesised by changing the amino acid sequence of  RGD motif and radiolabeled with freshly prepared [99mTc(CO)3(H2O)3]+ precursor (yield ˜ 97%). Radiolabeled peptides were substantially stable up to 24 h when incubated with saline, serum and histidine solution (10-2 M), also exhibited significant and rapid internalization in both EAC and αvβ3-positive B16F10 mouse melanoma cell line. Fast blood clearance, rapid urinary excretion and significantly high tumor to muscle ratios are encouraging enough to carry out further experiments for targeting tumor.

  2. Synthesis and Cytotoxicity Studies of Novel Triazolo-benzoxazepine as New Anticancer Agents

    Biswadip Banerji, Sumit Kumar Pramanik, Priyankar Sanphui, Sameer Nikhar and Subhas Chandra Biswas

    Accepted manuscript online: 15 MAY 2013 03:16AM EST | DOI: 10.1111/cbdd.12164

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    The one pot procedure for the efficient synthesis of a small library of Novel triazolo-benzoxazepine. These comp ounds were evaluated for anticancer activity against three different cancer lines(Neura 2a, Hek 293, Hep G2). The phase-contrast images, fluorescent microscope images and confocal images unambiguously confirm the cell-death.

  3. Synthesis, anti-MRSA and anti-VRE activity of hemin conjugates with amino acids and branched peptides

    S.A Okorochenkov, G.A. Zheltukhina, E.P. Mirchink, E.B. Isakova, A.V. Feofanov and V.E. Nebolsin

    Accepted manuscript online: 11 MAY 2013 10:11AM EST | DOI: 10.1111/cbdd.12163

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    The number of hemin conjugates with amino acids and branched peptides were synthesized. High antibacterial activity of synthesized compounds against Gram positive bacteria including methicillin - and vancomycin-resistant strains was shown. Hemolytic and cytotoxic assays indicated that majority of synthesized conjugates possess lower toxicity and hemolytic activity than hemin.

  4. Design, Synthesis and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands

    Peng Du, Lili Xu, Jiye Huang, Kunqian Yu, Rui Zhao, Bo Gao, Hualiang Jiang, Weili Zhao, Xuechu Zhen and Wei Fu

    Accepted manuscript online: 11 MAY 2013 10:11AM EST | DOI: 10.1111/cbdd.12158

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    Using a strategy that combines synthetic chemistry, binding assays and a set of computational approach, we designed a series of indolebutylamine (IBA) derivatives as a new type of highly selective D3R liands. Molecular determinants critical to the binding specificity and selectivity of D3R were identified and the SAR was investigated to understand the recognition of this type of D3R ligands.

  5. In-vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases

    Carolina Mascayano, Victoria Espinosa, Silvia Sepúlveda-Boza, Eric K. Hoobler and Steve Perry

    Accepted manuscript online: 11 MAY 2013 10:10AM EST | DOI: 10.1111/cbdd.12157

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