Chemical Biology & Drug Design

Cover image for Vol. 85 Issue 2

Edited By: David Selwood

Impact Factor: 2.507

ISI Journal Citation Reports © Ranking: 2013: 28/58 (Chemistry Medicinal); 173/291 (Biochemistry & Molecular Biology)

Online ISSN: 1747-0285

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Editor's Choice

Computer-Aided Drug Discovery Approach Finds Calcium Sensitizer of Cardiac Troponin

Steffen Lindert, Monica X. Li, Brian D. Sykes and J. Andrew McCammon

Specific Interaction

In the fight against heart failure, therapeutics that increase the calcium sensitivity of the thin filament are a promising option to improve heart contractile power. Here, we combined computational drug discovery methods and solution NMR titration assays to identify a novel calcium sensitizer which binds to cTnC and the cTnC-cTnI147–163 complex. Its presence increases the affinity of switch peptide to cTnC by approximately a factor of two, making its action comparable to that of known levosimendan analogues.

This issue’s Editor’s Choice was chosen by Masahiro Okuyama

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Meet the Editorial Team

We are pleased to announce that a member of our Editorial Board, Jurgen Bajorath, has won the 2015 Skolnik Award for his outstanding contributions to information science.

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