Chemical Biology & Drug Design

Cover image for Vol. 89 Issue 2

Edited By: David Selwood

Impact Factor: 2.802

ISI Journal Citation Reports © Ranking: 2015: 26/59 (Chemistry Medicinal); 138/289 (Biochemistry & Molecular Biology)

Online ISSN: 1747-0285

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Editor's Choice

Design features for optimization of tetrapyrrole macrocycles as antimicrobial and anticancer photosensitizers

Alejandra Martinez De Pinillos Bayona, Pawel Mroz, Connor Thunshelle and Michael R. Hamblinn
Volume 89, Issue 2

Photodynamic therapy (PDT) uses non-toxic dyes called photosensitizers (PS) and harmless visible light that combine to form highly toxic reactive oxygen species that kill cells. PS are often tetrapyrrole macrocycles including porphyrins, chlorins, bacteriochlorins, and phthalocyanines. We discuss drug-design parameters including hydrophobicity, charge, molecular asymmetry that influence subcellular localization and pharmacokinetics.

This issue’s Editor’s Choice was chosen by David Selwood

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Meet the Editorial Team

We are pleased to announce that a member of our Editorial Board, Jurgen Bajorath, has won the 2015 Skolnik Award for his outstanding contributions to information science.

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