New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities
Lanussy Porfiro de Oliveira, Daiany Priscilla Bueno da Silva, Iziara Ferreira Florentino, James Oluwagbamigbe Fajemiroye, Thiago Sardinha de Oliveira, Renato Ivan de Ávila Marcelino, Francine Pazini, Luciano Morais Lião, Paulo César Ghedini, Soraia Santana de Moura, Marize Campos Valadares, Verônica Vale de Carvalho, Boniek Gontijo Vaz, Ricardo Menegatti and Elson Alves Costa
Version of Record online: 14 SEP 2016 | DOI: 10.1111/cbdd.12838
Given pyrazole compounds' antipyretic, analgesic, and anti-inflammatory effects, we describe the synthesis and pharmacotoxicological evaluation of a new pyrazole derivative, 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole, as well as the antinociceptive, anti-inflammatory activity and involvement of the NO/cGMP pathway and ionic channels in its vasorelaxant effect. The blockade of voltage-dependent calcium channels could have also contributed to the vasorelaxant effect of the compound, which demonstrated a low toxicological profile promising antinociceptive, anti-inflammatory, and vasorelaxant effects.