Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives
Naraganahalli R. Thimmegowda, Chanmi Park, Bettaswamigowda Shwetha, Krisada Sakchaisri, Kangdong Liu, Joonsung Hwang, Sangku Lee, Sook J. Jeong, Nak K. Soung, Jae H. Jang, In-Ja Ryoo, Jong S. Ahn, Raymond L. Erikson and Bo Y. Kim
Article first published online: 5 NOV 2014 | DOI: 10.1111/cbdd.12448
In the present study we have synthesized natural compound aloe emodin derivatives 4(a – j) to improve the anticancer activity and to explore the structure-activity relationships. Cell growth inhibition assays revealed that the aloe emodin derivatives 4d, 4f and 4i effectively decreased the growth ofHepG2 (human liver cancer cells), NCI-H460 (human lung cancer cells) and some of the derivatives exhibited comparable antitumor activity against HeLa (Human epithelial carcinoma cells) and PC3 (prostate cancer cells) cell lines compared to that of the parent aloe emodin at low micro molar concentrations.