International Journal of Stroke

Cover image for Vol. 10 Issue 1

Edited By: Geoffrey Donnan

Impact Factor: 4.029

ISI Journal Citation Reports © Ranking: 2013: 13/65 (Peripheral Vascular Disease)

Online ISSN: 1747-4949

Associated Title(s): World Stroke Academy

Virtual Issues

Virtual Issues from International Journal of Stroke

Panorama: Europe,

Published: 30 Nov 2009


I'm delighted with the latest IJS initiative to provide, via online virtual issues, compilations of articles that have been the most popular with our readers. This issue consisting of all our Panorama articles to date emphasizes the broad global reach of our journal, with submissions from almost every point of the world.

As you can see, we have arranged them regionally including Europe, North and South America, Australia and New Zealand, Africa, Asia and the Middle East.

The articles generally focus on the burden of disease and the particular structures in place to manage its ever-increasing reach. We also have an interesting theme on Indigenous peoples and stroke nursing. The popularity of our Panorama section in part reflects the paucity of information from many parts of the world about stroke and its unacceptable burden; unfortunately, this is more so for the developing world than elsewhere. We hope that this collection of articles redresses this imbalance to some extent.

We see our role as journal editors to promote change by communicating the extent of the stroke burden and the new and exciting developments that will eventually lead to its reduction; we think we are succeeding!

The burden of paediatric stroke and cerebrovascular disorders in Croatia
J. Lenicek Krleza, V. Duranovic, L. Lujic, D. Coen Herak, V. Mejaski-Bosnjak, M. Nakic, R. Zadro

Stroke Nursing in Scotland
Linda Campbell, Janet MacRae

Stroke in Norway
Bent Indredavik, Hanne Ellekjær, Randi Selmer

Burden of stroke in France
Didier Leys, Yannick Béjot, Stéphanie Debette, Maurice Giroud

Stroke service in Central and Eastern Europe
A. Czlonkowska, M. Skowroñska, M. Niewada

Hungarian Stroke Program: 1988–2006
Zoltan Nagy, Andras Javor, Peter Harcos, Michael Bodo

Thrombolysis for stroke in Poland: first 2 years of experience
Anna Czlonkowska, Adam Kobayashi, Marta Skowronska, Maciej Niewada, Iwona Sarzynska-Dlugosz

German Stroke Society
E. Bernd Ringelstein, Martin Grond, Otto Busse

Stroke unit care in Scandinavian countries
Markku Kaste, Gudrun Boysen, Bent Indredavik, Bo Norrving

Stroke care in the Russian Federation
Veronika I. Skvortsova

Virtual Issues from International Journal of Stroke

Panorama: North & South America,

Published: 29 Nov 2009

Stroke mortality in Brazil: one example of delayed epidemiological cardiovascular transition
Paulo A. Lotufo, Isabela M. Benseñor

Alaska Native Stroke Registry
Brian Trimble, Rebecca Hamel, Phillip Gorelick, Ronnie Horner, William Longstreth

Stroke in Southwest Native Americans
Anne W. Alexandrov, Annabelle Y. Lao, James L. Frey

The United States stroke system: credentialing and legislative efforts to improve acute stroke care
Anne W. Wojner-Alexandrov, Marc D. Malkoff

Stroke in Brazil: a South America perspective
Ayrton R. Massaro

Virtual Issues from International Journal of Stroke

Panorama: Australia & New Zealand,

Published: 28 Nov 2009

Burden of stroke in Maori and Pacific peoples of New Zealand
Valery L. Feigin, Harry McNaughton, Lorna Dyall

Aboriginal and Torres Strait Islander peoples and the burden of stroke
Amanda G. Thrift, Noel Hayman

Christopher Levi

Virtual Issues from International Journal of Stroke

Panorama: Africa,

Published: 27 Nov 2009

The burden of stroke in Nigeria
Kolawole Wasiu Wahab

Stroke in South Africa
Vivian Fritz

The neglected burden of stroke in Sub-Saharan Africa
Andre Pascal Kengne and Craig S. Anderson

Virtual Issues from International Journal of Stroke

Panorama: Asia,

Published: 26 Nov 2009

Burden of stroke in Indonesia
Y. Kusuma, N. Venketasubramanian, L. S. Kiemas, J. Misbach

A step forward in stroke care in Sri Lanka
P. S. Gunaratne

Development of stroke care in Sri Lanka
Padma S. Gunaratne, Arjuna Fernando, Vijay K. Sharma

Stroke care development in Mainland China: past, present and future
Chunxue Wang, Jingjing Li, Xingquan Zhao, Yilong Wang, Di Wu, Yongjun Wang

Burden of stroke in Singapore
N. Venketasubramanian, C. L. H. Chen

Stroke care in Vietnam
Nguyen Huu Cong

Burden of stroke in China
Yi Long Wang, Di Wu, Xiaoling Liao, Wei Zhang, Xingquan Zhao, Yong Jun Wang

Burden of stroke in Thailand
Niphon Poungvarin

The changing face of the burden of stroke in Japan
Yukito Shinohara

Stroke care in Korea including North Korea
Chin-Sang Chung, Kwang-Yeol Park

Burden of stroke: Indian perspective
Praful M. Dalal

Virtual Issues from International Journal of Stroke

Panorama: Middle East,

Published: 25 Nov 2009

The epidemiology of stroke in Pakistan: past, present, and future
M. U. Farooq, A. Majid, M. J. Reeves, G. L. Birbeck

Burden of stroke in Brunei Darussalam
S. H. Nainar, N. Venketasubramanian

The burden of stroke in Pakistan
Bhojo A. Khealani, Mohammad Wasay

Burden of stroke in Israel
S. Koton, D. Tanne, N. M. Bornstein

The development of Saudi Advisory Group Against Stroke (SAGAS)
Shireen Qureshi

Virtual Issues from International Journal of Stroke

Clinical Trial Protocols,

Published: 24 Nov 2009


This issue consisting of our Clinical Trial Protocol articles to date is unique, in that most journals do not publish this important preliminary component of the clinical trial process.

As one of our most popular sections of the Journal, our Clinical Trial Protocols inform our readers as to what clinical trials are underway, as well as provide a reference point for the investigators themselves. You will find a broad range of protocols in this collection ranging from the genetics of cervical artery dissections, to the International Stroke Trial (IST) III and the Very Early Rehabilitation Stroke Trial (AVERT). For those interested in citations, the IST III protocol has been one of the most frequently cited so far.

The philosophy that drives us is to educate, stimulate debate, and communicate high quality research to our readership. We see our role as journal editors to promote change by communicating the extent of the stroke burden and the new and exciting developments that will eventually lead to its reduction; we think we are succeeding!

The Asymptomatic Carotid Emboli Study: study design and baseline results
The ACES Investigators

A double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of Cerebrolysin in patients with Acute ischaemic Stroke in Asia – CASTA
Z. Hong, H. Moessler, N. Bornstein, M. Brainin, W.-D. Heiss

Stent-protected angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy: SPACE2 – a three-arm randomised-controlled clinical trial
T. Reiff, R. Stingele, H. H. Eckstein, G. Fraedrich, O. Jansen, H. Mudra, U. Mansmann, W. Hacke, P. Ringleb

CADISP-genetics: an International project searching for genetic risk factors of cervical artery dissections
S. Debette, T. M. Metso, A. Pezzini, S. T. Engelter, D. Leys, P. Lyrer, A. J. Metso, T. Brandt, M. Kloss, C. Lichy, I. Hausser, E. é, H. S. Markus, S. Abboud, V. Caso, A. Bersano, A. Grau, A. Altintas, P. Amouyel, T. Tatlisumak, J. Dallongeville, C. Grond-Ginsbach

'Getting your life back on track after stroke': a Phase II multi-centered, single-blind, randomized, controlled trial of the Stroke Self-Management Program vs. the Stanford Chronic Condition Self-Management Program or standard care in stroke survivors
M. Battersby, S. Hoffmann, D. Cadilhac, R. Osborne, E. Lalor, R. Lindley

Safety and dose-escalation study design of Transcranial Ultrasound in Clinical SONolysis for acute ischemic stroke: the TUCSON Trial
Andrew D. Barreto, Vijay K. Sharma, Annabelle Y. Lao, Peter D. Schellinger, Pierre Amarenco, Paul Sierzenski, Andrei V. Alexandrov, Carlos A. Molina

Comment on ITAIS
Geoffrey Donnan

Imaging-based thrombolysis trial in acute ischemic stroke-II (ITAIS-II)
Yilong Wang, Xiaoling Liao, Xingquan Zhao, Chunxue Wang, Liping Liu, Yong Zhou, Chunjuan Wang, Jing Xue, Peiyi Gao, Kehui Dong, Xunming Ji, Yongjun Wang

A double-blind, placebo-controlled, randomized, multicenter study to investigate CHInese Medicine Neuroaid Efficacy on Stroke recovery (CHIMES Study)
N. Venketasubramanian, C. L. H. Chen, R. N. Gan, B. P. L. Chan, H. M. Chang, S. B. Tan, D. Picard, J. C. Navarro, A. C. Baroque II, N. Poungvarin, G. A. Donnan, M. G. Bousser

Retinal microvascular signs: a key to understanding the underlying pathophysiology of different stroke subtypes?
Richard I. Lindley

The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke
Mitchell S. V. Elkind, Ralph L. Sacco, Robert B. MacArthur, Daniel J. Fink, Ellinor Peerschke, Howard Andrews, Greg Neils, Josh Stillman, Tania Corporan, Dana Leifer, Ken Cheung

Methodology of the Interventional Management of Stroke III Trial
Pooja Khatri, Michael D. Hill, Yuko Y. Palesch, Judith Spilker, Edward C. Jauch, Janice A. Carrozzella, Andrew M. Demchuk, Renee' Martin, Patrick Mauldin, Catherine Dillon, Karla J. Ryckborst, Scott Janis, Thomas A. Tomsick, Joseph P. Broderick

Design of the economic evaluation for the Interventional Management of Stroke (III) trial
Patrick D. Mauldin, Kit N. Simpson, Yuko Y. Palesch, Judy S. Spilker, Michael D. Hill, Pooja Khatri, Joseph P. Broderick

Magnesium in aneurysmal subarachnoid hemorrhage (MASH II) phase III clinical trial MASH-II study group
Sanne M. Dorhout Mees

Design of a PROspective multi-national CLOTBUST collaboration on reperfusion therapies for stroke (CLOTBUST-PRO)
Maher Saqqur, Georgios Tsivgoulis, Carlos A. Molina, Andrew M. Demchuk, Zsolt Garami, Andrew Barreto, Konstantinos Spengos, Alex Forteza, Robert Mikulik, Vijay K. Sharma, Alex Brunser, Patricia Martinez, Joan Montaner, Martin Kohrmann, Peter D. Schellinger, Andrei V. Alexandrov

The STRokE DOC trial technique: 'video clip, drip, and/or ship'
B. C. Meyer, R. Raman, R. Rao, R. D. Fellman, J. Beer, J. Werner, J. A. Zivin, P. D. Lyden

Cardio-protection in acute stroke
Jagdish C. Sharma, Ian Ross, Michael Vassallo

Comment on the CADISS trial protocol
Charles P. Warlow

Antiplatelet therapy vs. anticoagulation in cervical artery dissection: rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS)
The CADISS Trial Investigators

The Albumin in Acute Stroke Trial (ALIAS); design and methodology
Michael D. Hill, Claudia S. Moy, Yuko Y. Palesch, Renee Martin, Catherine R. Dillon, Bonnie Darcy Waldman, Lynn Patterson, Isabel M. Mendez, Karla J. Ryckborst, Diego Tamariz, Myron D. Ginsberg

The Basilar Artery International Cooperation Study (BASICS)
Wouter J. Schonewille, Christine A. C. Wijman, Patrik Michel, Ale Algra, L. Jaap Kappelle

VITATOPS, the VITAmins TO Prevent Stroke trial: rationale and design of a randomised trial of B-vitamin therapy in patients with recent transient ischaemic attack or stroke (NCT00097669) (ISRCTN74743444)
The VITATOPS Trial Study Group

Promoting acute thrombolysis for ischaemic stroke (PRACTISE) : Protocol for a cluster rand