Brain Pathology

Cover image for Vol. 28 Issue 1

Edited By: Seth Love

Impact Factor: 6.624

ISI Journal Citation Reports © Ranking: 2016: 5/79 (Pathology); 15/194 (Clinical Neurology); 21/259 (Neurosciences)

Online ISSN: 1750-3639

AUTOPHAGY

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Autophagy induction and autophagosome formation. This diagram shows the process of autophagy induction and roles of Atg related proteins in autophagosome formation.

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Overview of autophagic flux and impaired states in neurodegenerative diseases. This schematic diagram shows the procedures through the autophagic flux from formation of the autophagosome to fusion with the lysosome. Red text highlights refer to the dysfunctional steps in autophagy, along with related neurodegenerative diseases. Arrows' directions stand for activation or inhibition.

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Autophagy in neurodegenerative diseases: pathogenesis and therapy

    Molecular targets of autophagy up-regulating agents. This schematic diagram shows representative molecular agents involved in autophagy activation through regulating autophagy-related pathways. Either the mTOR-dependent or mTOR-independent pathway could play a negative role in autophagy. In addition, suppression of these pathways will result in activation of autophagy.

  • Autophagy in neurodegenerative diseases: pathogenesis and therapy
  • Autophagy in neurodegenerative diseases: pathogenesis and therapy
  • Autophagy in neurodegenerative diseases: pathogenesis and therapy

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