Brain Pathology

Cover image for Vol. 25 Issue 4

Edited By: Seth Love

Impact Factor: 3.84

ISI Journal Citation Reports © Ranking: 2014: 11/75 (Pathology); 35/192 (Clinical Neurology); 72/252 (Neurosciences)

Online ISSN: 1750-3639

Author Guidelines

Scope. The official journal of the ISN is intended to be a forum for recent progress in the science and practice of neuropathology, with a strong emphasis on disease mechanisms. It will be broad in scope, encompassing advances in neighboring disciplines, including cell biology, molecular genetics, immunology and virology. Although primarily directed to pathologists, Brain Pathology addresses all members of the scientific community interested in diseases of the nervous system.

Content. Brain Pathology publishes original research articles, reviews, historical notes and, in each issue, a symposium on a specific topic which is compiled by a guest editor. If you wish to write a review for Brain Pathology, please contact the editor preferably with a brief outline of your intended submission.

Manuscript Submission. Manuscripts should be submitted online at Full instructions are provided on the site. Submissions should be uploaded as Rich Text Format (RTF) files plus separate figure files. GIF, JPEG, PICT or Bitmap files are acceptable for submission, but only TIF or EPS files (as detailed at the end of this page) are suitable for printing.

Note to NIH Grantees

Pursuant to NIH mandate, Wiley-Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance. The accepted version will be made publicly available 12 months after publication. For further information, please see


If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper. The corresponding author MUST submit the CTA as it is a requirement for publication.

For authors signing the copyright transfer agreement
If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions

For authors choosing OnlineOpen
If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):

Creative Commons Attribution License OAA
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and

If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements.

For more information on this policy and the Journal’s compliant self-archiving policy please visit:

Additionally. authors are themselves responsible for obtaining permission to reproduce copyright material from other sources.

Color Figures. All submitted color figures MUST be in CMYK and not RGB mode. More information can be found on or

Colour figures in papers accepted after 5 November 2012 will be reproduced free of charge to authors.

Page Charges. Authors will be charged £60 for each page in the final published version. As a rule of thumb, an average text page in the printed issue (without figures and tables) is approximately 900 words.

OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see

Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website at:

Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

Accepted Articles. Brain Pathology  now offers Accepted Articles for all full articles, whereby peer reviewed, accepted articles are published online soon after acceptance, without having been copy-edited or typeset. Accepted Articles appear in PDF-only format, without the accompanying full-text HTML. Each manuscript is assigned a Digital Object Identifier (DOI), which allows the article to be cited and tracked before it is allocated to an issue. After print publication, the DOI remains valid and can continue to be used to cite and access the article.

Early View. Brain Pathology is covered by Wiley-Blackwell’s Early View service. Early View articles are complete full-text articles published online in advance of their publication in a printed issue. Articles are therefore available as soon as they are ready, rather than having to wait for the next scheduled print issue. Early View articles are complete and final. They have been fully reviewed, revised and edited for publication, and the authors’ final corrections have been incorporated. Because they are in final form, no changes can be made after online publication. They are given a Digital Object Identifier (DOI), which allows the article to be cited and tracked. After publication, the DOI remains valid and can continue to be used to cite and access the article.

Referrals to the journal "Brain and Behavior." This journal works together with Wiley's Open Access Journal, Brain and Behavior, to enable rapid publication of good quality research that is unable to be accepted for publication by our journal. Authors will be offered the option of having the paper, along with any related peer reviews, automatically transferred for consideration by the Editor of Brain and Behavior. Authors will not need to reformat or rewrite their manuscript at this stage, and publication decisions will be made a short time after the transfer takes place. The Editor of Brain and Behavior will accept submissions that report well-conducted research which reaches the standard acceptable for publication. Accepted papers can be published rapidly: typically within 15 days of acceptance. Brain and Behavior is a Wiley Open Access journal and article publication fees apply. For more information please go to

Title. Give a concise title with no abbreviations. Provide first and last names of all authors, together with their institutional affiliations. This page should also contain the full address of the corresponding author, with telephone, fax numbers and E-mail address. The title must be styled in bold and in uppercase.

Abstract. An abstract (of 200 words or less) is required for original research articles, technical notes, reviews and contributions to Brain Pathology's symposia.

Tables. Tables should be concise and easy to comprehend. They must have a title and be cited in the text.

Figures. If submitting artwork electronically, please read the information on the Wiley-Blackwell's website at:

Vector graphics (e.g. line artwork) should be saved in Encapsulated Postscript Format (EPS), and bitmap files (e.g. photographs) in Tagged Image File Format (TIFF). Line art must be scanned at a minimum of 800 dpi, photographs at a minimum of 300 dpi.

Reviewers.  Authors are required to provide the names of at least three preferred reviewers.

References. Only published papers and those in press should be included in the reference list. Unpublished data, submitted manuscripts and personal communications should be cited parenthetically in the text. References should be cited as numbers in parentheses. In the reference list, references are to be arranged alphabetically and numbered accordingly. Therefore, the numbers in parentheses in the text will not reflect a sequential order. All authors should be cited. Journal names should be abbreviated according to the Index Medicus. The following are examples of Brain Pathology’s reference style:

1. Forno LS, Eng LF, Selkoe DJ (1989) Pick bodies in the locus coeruleus. Acta Neuropathol 79:10-17.

2. Raine CS (1985) Demyelinating diseases. In: Textbook of Neuropathology, Davis RL, Robertson DM (eds.), Chapter 11, pp. 468-547, Williams & Wilkins: Baltimore, London, Sydney.

3.  Russell DS, Rubinstein LJ (1989) Pathology of Tumours of the Nervous System, 5th Edition, Edward Arnold: London, Melbourne, Auckland.

(A) Submitting a Case of the Month to Brain Pathology (COM)

NOTE:  Please contact the Case Editor, Dr. Hamilton ( with a short description of the case and the diagnosis before preparing it and sending it. Also be aware that this feature is very popular and the time between acceptance and publication is currently 8-12 months.

Cases are to be presented as “unknowns” and should be designed to stimulate the production of a differential diagnosis by readers. Unlike a “Case report”, a Case of the Month is primarily meant to be used as a teaching tool for both neuropathologists and others interested in neuropathological lesions.  It is therefore important that the case have a definitive diagnosis. 

Classic, but rare neuropathological entities are encouraged, but even “common” tumors or conditions can be used, especially if well-presented, or if they have an atypical location or clinical picture. 

Each Case is published in two formats: on the WEB and later in PRINT in Brain Pathology.  

Reprints are NOT available for COM.

Cases are listed as Correspondence by the ISI.

Contributing a case is relatively simple:

The example below is a template for the formatting:

Markus J. Hofer, MD1, Jochen Rohlfs, MD2, Afshin Teymoortash, MD3, Axel Pagenstecher, MD1
Departments of 1Neuropathology, 2Neurosurgery and 3Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany.

A 62-year old female patient presented with constricted nasal breathing on the right side

Paraffin sections showed a cellular tumor forming compact local connective tissue and glands that appeared inconspicuous

Light microscopy showed a cellular, lobulated tumor with (Figure 12, arrows) but not cytokeratin.

Sinonasal undifferentiated carcinoma (SNUC).

Two aspects make this case of significant interest. Firstly, the differential diagnosis of tumors like the one presented here often poses a challenge to the (neuro-)pathologist. This is because it includes several entities that can neuroendocrine differentiation but also supports the assumption that the SNUC originates from resident cells of the sinonasal mucosa.


Malignant tumors with neuroendocrine differentiation of the nasal cavity include neuroendocrine carcinoma, small cell process originated from local glands present in the nasal mucosa.


References– (please use the same format as Brain Pathology articles).

  • Example of Reference format: Astrinidis A, Henske EP (2005) Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 24:7475-7481.
  • Please limit bibliography to 10 references or less.
  • These should be in alphabetical order.

A short abstract (less than 200 words) is also needed for the print version.  This is for PubMed searches so be sure to include all key words.

In the microscopic description, avoid descriptions which reveal the “answer” (i.e., don’t write “Cowdry type A inclusions were present” instead use language such as “many nuclei showed abnormalities (fig x). Keep in mind that these are meant to be used as unknown teaching cases for all levels of neuropathology training).

Note that there are no figure legends. Figures are described in the body of the text (see examples of printed cases in Brain Pathology).

The Discussion should include a differential diagnosis of the radiology and microscopy as well as a short review of the particular pathologic entity.

For the WEB version there is no text limit.

For the PRINT version, the DIAGNOSIS/DISCUSSION/REFERENCES/ABSTRACT section must all fit onto a single page (Times new Roman, 9, single space, two column)

An electronic version of the text can be e-mailed as an e-mail attachment ( or sent to me on a CD at the address below. Please specify the word processing program and if the disc is a Mac or PC format.

FIGURES must be sent as TIFF digital images in CMYK color mode. The resolution needs to be 400 dpi for color images, 600 dpi for grayscale and 1200 dpi for black and white. The minimum width for these needs to be 3.125 inches or 8 cm.

Digital images can also be e-mailed to but due to server space limitations please each image as an individual e-mail. Do not send on weekend. Please send between 9am and 4pm Eastern Standard Time, so I can move them out of my e-mail box before it fills up.


There is no fee for the contribution (unlike article submissions) and no charges for color figures – in fact, black and white images are accepted ONLY for radiology and electron micrographs!

Examples of web cases can be found by following the links on the Publisher's page.

OR a list of all COM since April 1996 can be found at:

Do not hesitate to contact me if there are further questions.

Ronald Hamilton, M.D.
Associate Professor of Pathology (Neuropathology)
Presbyterian University Hospital
South Wing M8709
200 Lothrop St
Pittsburgh PA 15213
Phone: (412) 647-6615
Fax: (412) 647-5602

Proofs. Page proofs will be sent to the corresponding author and should be returned within 3 days of receipt to the Production Editor. Significant textual alterations are unacceptable at proof stage without the written approval of the Editor, and they are likely to result in the delay of publication.

The corresponding author will receive an e-mail alert containing a link to a secure web site. A working e-mail address must therefore be provided for the corresponding author. In the absence of the corresponding author, please arrange for a colleague to access the e-mail to retrieve the proofs.

Please note that you have final responsibility for what is stated in the proofs of your manuscript.

Society News

Information to be published in the section entitled Society News should be forwarded to:

Dr. Homa Adle-Biassette
Inserm U676, Université Paris Diderot (P7)
Hôpital Robert Debré 48
Bd Sérurier
75019 Paris, France
Tel.: 00 33 (0)1 40 03 19 72
Fax: 0 33 (0)1 40 03 19 95

Pre-submission English Language Editing Services. Authors for whom English is not their first language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at

Japanese authors can also find a list of local English improvement services at All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.

NEW: Online production tracking is now available for your article through Wiley-Blackwell's Author Services
Author Services enables authors to track their article - once it has been accepted - through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The author will receive an e-mail with a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Free access to the final PDF offprint of your article will be available via author services only. Please therefore sign up for author services if you would like to access your article PDF offprint and enjoy the many other benefits the service of