Antimicrobial Photodynamic Efficiency of Novel Cationic Porphyrins towards Periodontal Gram-positive and Gram-negative Pathogenic Bacteria
Chandra Sekhar Prasanth, Suneesh C. Karunakaran, Albish K. Paul, Vesselin Kussovski, Vanya Mantareva, Danaboyina Ramaiah, Leslie Selvaraj, Ivan Angelov, Latchezar Avramov, Krishnankutty Nandakumar and Narayanan Subhash
Article first published online: 17 DEC 2013 | DOI: 10.1111/php.12198
We describe the synthesis and in vitro photodyanamic activity of two cationic porphyrin derivatives using Gram-positive as well as Gram-negative bacteria. These porphyrin derivatives exhibited favorable photophysical properties including high quantum yields of the triplet excited state and singlet oxygen generation efficiency. Furthermore, the in vitro studies indicated that these derivatives accumulate into bacterial cells and biofilms, and exhibit high antibacterial activity upon NIR excitation. Our results demonstrate that these cationic porphyrins can act as sensitizers for effective photoinactivation of bacterial strains associated with periodontitis and thereby their potential application in antibacterial photodynamic therapy.