Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01
Qiping Chen, Meixin Shen, Yee Kiat Heng, Thiam Seng Colin Theng, Hong Liang Tey, Ee Chee Ren and Wei-Sheng Chong
Article first published online: 11 FEB 2016 | DOI: 10.1111/php.12569
Studies have reported the association of human leukocyte antigen (HLA) genes with susceptibility to develop actinic prurigo (AP) in Caucasians, but there were no studies in Asian populations, including the Chinese. Our study was performed to determine if AP is associated with susceptibility or protective HLA alleles or haplotypes in Singaporean Chinese. We found that HLA-DRB1*03:01 was associated with AP in Singaporean Chinese patients. This novel allelic association may possibly be utilized as a biological marker to aid in the diagnosis of AP in Chinese patients.