Photodynamic Diagnosis Using 5-Aminolevulinic Acid in 41 Biopsies for Primary Central Nervous System Lymphoma
Tetsuya Yamamoto, Eiichi Ishikawa, Shunichiro Miki, Noriaki Sakamoto, Alexander Zaboronok, Masahide Matsuda, Hiroyoshi Akutsu, Kei Nakai, Wataro Tsuruta and Akira Matsumura
Article first published online: 15 SEP 2015 | DOI: 10.1111/php.12510
Positive fluorescence was observed in 34 of 41 biopsies (82.9%) obtained under 5-aminolevulinic acid-mediated photodynamic diagnosis (PDD) for primary central nervous system lymphoma (PCNSL) as final pathological diagnosis. In 21 of the 34 biopsies (61.8%), an intraoperative pathological diagnosis (IOD) of suspected PCNSL was made. In the remaining 13 biopsies, however, the IOD was either incorrect (atypical cell, 4; high-grade glioma, 1; gliosis, 1; unremarkable, 2) or not performed (5). PDD of biopsy samples in patients with suspected PCNSL is a feasible way to obtain accurate samples and may lead to improved diagnostic yield in the biopsy of PCNSL.