Hypericin as a Marker for Determination of Myocardial Viability in a Rat Model of Myocardial Infarction
Cuihua Jiang, Yue Li, Xiao Jiang, Nan Yao, Meng Gao, Xueli Zhang, Junying Wang, Xiaoning Wang, Ziping Sun, Jian Zhang and Yicheng Ni
Article first published online: 26 FEB 2014 | DOI: 10.1111/php.12247
The aim of this study was to investigate the necrosis avid agent hypericin as a potential indicator for determination of myocardial infarction. Animals were challenged with different doses of hypericin (0, 1, 2, and 5 mg kg−1) after an experimental myocardial infarction. Infarct-to-normal contrast ratio and relative infarct size were evaluated by fluorescence macroscopy in colocalization with triphenyltetrazoliumchloride and histomorphology. Results confirm that hypericin specifically labeled necrosis, and enhanced the imaging contrast between the infarcted and normal myocardium, suggesting its potential applications for the assessment of myocardial viability.