In Vitro Photodynamic Inactivation Effects of Ru(II) Complexes on Clinical Methicillin-resistant Staphylococcus aureus Planktonic and Biofilm Cultures
Yucheng Wang, Qianxiong Zhou, Ying Wang, Jie Ren, Hongyou Zhao, Sumin Wu, Jiyong Yang, Jie Zhen, Yanping Luo, Xuesong Wang and Ying Gu
Article first published online: 5 DEC 2014 | DOI: 10.1111/php.12378
Photodynamic inactivation (PDI) is a compelling alternative treatment for infections, especially those caused by multidrug-resistant bacteria. In this study, a novel class of cationic photosensitizers, Ru(II) complexes, has been tested in their PDI effects against clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, both in planktonic and biofilm cultures. Mechanisms of the PDI process were also investigated. It was demonstrated that PDI of planktonic bacteria was achieved primarily through damage to the cell envelope. Biofilms were eliminated through both the destruction of their structure and inactivation of the individual bacteria.