Fluorinated Photodynamic Therapy Device Tips and their Resistance to Fouling for In Vivo Sensitizer Release
Ashwini A. Ghogare, Joann M. Miller, Bikash Mondal, Alan M. Lyons, Keith A. Cengel, Theresa M. Busch and Alexander Greer
Article first published online: 4 NOV 2015 | DOI: 10.1111/php.12538
A one-step process (i.e. simultaneous delivery of sensitizer, oxygen and light) has been developed to simplify the application of PDT. We have analyzed the potential fouling of the PDT device tips with biomaterial from SQ20B squamous cell carcinoma tumors and whole blood. Measurements included sensitizer output inhibition and also biomaterial adhesion by a bicinchoninic acid assay and X-ray photoelectron spectroscopy. A fluorinated device tip led to improved biofouling resistance based on sensitizer photorelease performance and other factors.