INVITED REVIEW: Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions
RESEARCH ARTICLE: One-Pot Fabrication of RGO–Ag3VO4 Nanocomposites by in situ Photoreduction using Different Sacrificial Agents: High Selectivity Toward Catechol Synthesis and Photodegradation Ability
Uveal melanoma is the second most common form of melanoma (after skin) and the most frequent form of intraocular cancer. The importance of sunlight exposure in the incidence of skin melanoma is well defined. However, accumulation of sunlight exposure still has to be proven as a risk factor for uveal melanoma. The cover picture depicts the potential relation of sunlight exposure with the uveal melanoma. The weak transmission of ultraviolet light to the posterior part of the human eye is in contradiction with the possible role of these wavelengths in the incidence of uveal melanoma. Accordingly, when analyzing the mutational spectrum of uveal melanomas, a majority of non-UV related mutations are found. On the other hand, the mutation pattern of uveal melanoma bears strong similarities with the one found in skin melanoma. Thus, there are some evidences of the implication of sunlight radiations in the incidence of the uveal melanoma, but the subject is still open for debate. In their review, Mallet et al. paint an extensive picture of the research made over the last decades regarding the potential role of ultraviolet light in the etiology of uveal melanoma.
Virtual Issue: Type I and II Photosensitized Oxidation in Chemistry and Biology