Clinical and Experimental Neuroimmunology

Cover image for Vol. 5 Issue 2

Edited By: Takashi Yamamura, Akio Suzumura, Jun-ichi Kira, Takashi Kanda

Online ISSN: 1759-1961

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Highlight Articles - Free Online

Clinical features and treatment status of adult myasthenia gravis in Japan
Hiroyuki Murai, Masayuki Masuda, et al.

Decreased CCR2 and CD62L expressions on peripheral blood classical monocytes in amyotrophic lateral sclerosis
Yi Wen Cui, Yuji Kawano, et al.

Genetic and environmental factors underlying the rapid changes in epidemiological and clinical features of multiple sclerosis and neuromyelitis optica in Japanese
Jun-ichi Kira

Reactive astrocytes and perivascular macrophages express NLRP3 inflammasome in active demyelinating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction
Natsuki Kawana, Yoji Yamamoto, et al.

Establishment and characterization of spinal cord microvascular endothelial cell lines
Toshihiko Maeda, Yasuteru Sano, et al.

Distinct genetic profiles between Japanese multiple sclerosis patients with and without Barkhof brain lesions
Jian Huang, Noriko Isobe, et al.

Association of serum vitamin D levels in Japanese patients with multiple sclerosis
Masaaki Niino, Toshiyuki Fukazawa, et al.

Diagnostic spectrum of multifocal motor neuropathy
Naoko Matsui, Ai Miyashiro, et al.

Interleukin-27 promotes inflammatory and neuroprotective responses in microglia
Jun Kawanokuchi, Hideyuki Takeuchi, et al.

Roles of two non-structural viral proteins in virus-induced demyelination
Toshiki Himeda, Yoshiro Ohara

Role of CCR2 in immunobiology and neurobiology
Ryo Yamasaki, LiPing Liu, et al.

Neurotoxicity by microglia: Mechanisms and potential therapeutic strategy
Hideyuki Takeuchi

Microglia as immune effectors of the central nervous system: Expression of cytokines and chemokines
Seung U. Kim and Atsushi Nagai

T cell migration into the central nervous system during health and disease: Different molecular keys allow access to different central nervous system compartments
Britta Engelhardt

What drives disease in multiple sclerosis: Inflammation or neurodegeneration?
Hans Lassmann

Identifying targets for autoantibodies in CNS inflammation: Strategies and achievements
Edgar Meinl, Tobias Derfuss and Chris Linington

Plasmapheresis for neuroinflammatory disorders
Alexandra Schröder, Ralf A. Linker and Ralf Gold

Cytokines and chemokines in inflammatory demyelinating neuropathies
Robert P. Lisak

Bioinformatics approach to identifying molecular biomarkers and networks in multiple sclerosis
Jun-ichi Satoh

Involvement of semaphorins and their receptors in neurological diseases
Noriko Takegahara and Atsushi Kumanogoh

Special Issue -Free online

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Cutting Edge Research in MS and NMO from Asia

This special issue publishes articles from the 12th Annual Meeting of the Multiple Sclerosis (MS) Workshop (Kyushu University School of Medicine, August 3-4 2013)

Special Issue on Cutting Edge Research in MS and NMO from Asia

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Message from the New President
Aim of the Japanese Society of Neuroimmunology and the Emerging Roles of Clinical and Experimental Neuroimmunology
Jun-ichi Kira

Launch of New Review/Editing System for Clinical and Experimental Neuroimmunology
Clinical and Experimental Neuroimmunology (CENI) has published three issues annually for the past 3 years. We are pleased to announce that from Volume 4 Issue 1 in 2013, the journal has launched a revised review/editing system. In the past, one Editor-in-Chief was in charge of review/editing, but from now on four Chief Editors will be in charge of the review/editing for different research fields. This change was implemented because Neuroimmunology covers a vast range of research fields and submission of papers to CENI has been increasing in various Neuroimmunology areas, with the research areas ranging from Basic to Clinical, and target organs from the central nervous system to peripheral nerves and muscles. With all these factors, enhancement of reviewing/editing system was essential. It is expected that the new system will enable more prompt and thorough reviews than before.

Prof. Takashi Kanda, who was in charge as Editor-in-Chief, will handle PNS Disease as a Chief Editor. Prof. Takashi Yamamura, who was Associate Editor, will handle Immunology as a new Chief Editor. Moreover, Prof. Akio Suzumura, former President of the Japanese Society of Neuroimmunology, will handle Neuroscience as a new Chief Editor. Prof. Jun-ichi Kira, current President of the Japanese Society of Neuroimmunology, will handle CNS Disease as a new Chief Editor. The Secretariat of CENI will be located at Department of Neurology, Neurological Institute, Kyushu University, Japan. Dr. Hiroyuki Murai will be added as the managing editor as well as a Chief of the Secretariat and will handle reviews for Neuromuscular Junction and Muscle Diseases. Therefore, the review/editing of CENI will now be conducted by these five members. Under the new system, polite and detailed reviews/advice and an editing plan will be provided to authors in a timely manner.

The study area for Neuroimmunology has recently made outstanding progress, including the discovery of new autoantibodies such as the anti-aquaporin-4-antibody for neuromyelitis optica, and the development of various disease modifying drugs for multiple sclerosis. The critical involvement of the immune system, for example through neuroglial inflammation, has become clearer, not only in existing neuroimmunological diseases, such as multiple sclerosis and myasthenia gravis, but also in neurodegenerative disorders, such as Alzheimer disease and amyotrophic lateral sclerosis.

CENI will focus on neuroimmunological research aspects including neuroimmunological and neurodegenerative diseases. There have been indications that common molecules conducting important functions exist between neural and immune systems. Immunological and brain science studies exploring the close relationships between immunity and the brain are expected to expand. We intend to extensively convey new information to the world from basic to clinical research in these areas.

To achieve these aims, we have decided to accept not only invited, but also submission at large in regard to the existing review and commentary categories. A new category of Images in Neuroimmunology will be created in addition to that of Case Report. The submission of high-impact pictures will be greatly welcomed. Various Congress Reports will also be published. We intend to contribute to better communication among researchers in the area of Neuroimmunology. Finally, cutting-edge original research articles will come first. We all look forward to the submission of original research articles from researchers and clinicians in various areas.

February 7, 2013
Takashi Yamamura
Chief Editor
Department of Neuroimmunology
National Center of Neurology and Psychiatry
National Institute of Neuroscience

Akio Suzumura
Chief Editor
Department of Neuroimmunology
Research Institute of Environmental Medicine, Nagoya University

Jun-ichi Kira
Chief Editor
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University

Takashi Kanda
Chief Editor
Department of Neurology and Clinical Neuroscience
Yamaguchi University Graduate School of Medicine

Hiroyuki Murai
Managing Editor
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University