Clinical and Experimental Neuroimmunology

Cover image for Vol. 7 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Takashi Yamamura, Akio Suzumura, Jun-ichi Kira, Takashi Kanda

Online ISSN: 1759-1961


  1. 1 - 11
  1. Review Articles

    1. Future treatment for Guillain–Barré syndrome

      Satoshi Kuwabara and Sonoko Misawa

      Version of Record online: 18 OCT 2016 | DOI: 10.1111/cen3.12343

      In Guillain-Barré syndrome, even treated with the currently best therapy , the mortality rate is still approximately 5%, and 20% of patients cannot walk unaided 6 months after onset. A better treatment is needed. Eculizumab, a humanized monoclonal antibody against complement C5, is a promising novel agents, and phase 1/2 trials are ongoing in Japan (Japanese eculizumab trial for GBS: JET-GBS) and Scotland (Inhibition of compliment activation for GBS: ICA-GBS).

    2. History of Guillain–Barré syndrome

      Susumu Kusunoki

      Version of Record online: 9 OCT 2016 | DOI: 10.1111/cen3.12339

    3. You have free access to this content
      Node of Ranvier disruption in Guillain–Barré syndrome

      Keiichiro Susuki

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/cen3.12338

      Thumbnail image of graphical abstract

      Rapid and efficient propagation of action potentials along myelinated nerve fibers depends on the high density of voltage-gated Na+ channels on the nodal axolemma. This review focuses on disruption of nodes of Ranvier during Guillain-Barré syndrome and related disorders.

  2. Case Report and Literature Review

    1. Dermatomyositis complicated with asymmetric peripheral neuritis on exacerbation: A case report and literature review

      Takashi Irie, Hiroshi Shigeto, Junpei Koge, Hiroo Yamaguchi, Hiroyuki Murai and Jun-ichi Kira

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/cen3.12332

      Thumbnail image of graphical abstract

      We report a 69-year-old woman with dermatomyositis who presented with asymmetric peripheral neuritis. Although our literature search revealed nine cases of dermatomyositis with polyneuropathy/polyradiculoneuropathy, most of which involved axonal neuropathy, this is the first case report of dermatomyositis presenting with mononeuritis multiplex. Our patient had recurrent episodes of dermatomyositis and mononeuritis multiplex, which were resolved by repeated intravenous methylprednisolone pulse, suggesting that repeated intravenous methylprednisolone pulse should be considered for such relapsing cases.

  3. Images in Neuroimmunology

    1. Clear detection of lower medullary lesions by three-dimensional double inversion recovery imaging in a patient with neuromyelitis optica spectrum disorder

      Satoshi Nagata, Koji Shinoda, Taira Uehara, Takuya Matsushita, Ryo Yamasaki and Jun-ichi Kira

      Version of Record online: 24 AUG 2016 | DOI: 10.1111/cen3.12330

      Thumbnail image of graphical abstract

      We showed that 3D-DIR images are also helpful for the visualization of punctate lesions in the medulla oblongata, which are not evident on T2-WI and FLAIR images. Although it has been reported that no cortical lesions were detectable in NMO patients, even on 3D-DIR images, it may be useful to evaluate the lower brainstem for lesions characteristic of NMO, which are usually difficult to visualize on T2-WI and FLAIR images.

  4. Original Articles

    1. You have free access to this content
      Relationship between damage-associated molecular patterns and cytokines in myasthenia gravis

      Akiyuki Uzawa, Tetsuya Kanai, Naoki Kawaguchi, Fumiko Oda, Yukiko Ozawa, Keiichi Himuro and Satoshi Kuwabara

      Version of Record online: 24 AUG 2016 | DOI: 10.1111/cen3.12331

      Thumbnail image of graphical abstract

      HMGB1 may be related with upregulation of IL-19 and APRIL levels in MG immunopathogenesis.

    2. You have free access to this content
      Seroprevalence of Toxoplasma gondii in Iranian patients with idiopathic Parkinson's disease

      Mahtab Ramezani, Maziar Shojaii, Marjan Asadollahi, Ehsan Karimialavijeh and Koorosh Gharagozli

      Version of Record online: 24 AUG 2016 | DOI: 10.1111/cen3.12329

      Thumbnail image of graphical abstract

      The study assesses T. gondii seropositivity in IPD patients, other neurological diseases and Healthy people. The frequency of anti-toxoplasmosis seropositivity were significantly higher in the IPD patients.

    3. You have free access to this content
      Peripheral blood T cell subset characteristics of multiple sclerosis in remission phase correlate with annualized relapse rates

      Zi-Ye Song, Yuri Nakamura, Ryo Yamasaki, Yuji Kawano, Koji Shinoda, Maimaitijiang Guzailiayi, Katsuhisa Masaki, Hiroo Yamaguchi, Takuya Matsushita and Jun-ichi Kira

      Version of Record online: 12 AUG 2016 | DOI: 10.1111/cen3.12321

      Thumbnail image of graphical abstract

      In the remission phase of MS, both anti-inflammatory cytokine-producing T cells and pro-inflammatory cytokine-producing T cells are increased; however, only the percentages of pro-inflammatory cytokine-producing T cells, such as IL9-producing CD4+ T cells, IL9-producing CD8+ T cells, and IFNγ- and IL17-producing CD8+ T cells, correlate with annualized relapse rates. These pro-inflammatory cytokine-producing T cells in the remission phase may be candidate biomarkers for future relapses in MS patients.

  5. Case Reports

    1. Case of Morvan syndrome with anti-Ma2/Ta antibodies

      Kenya Nishioka, Yasunobu Hoshino, Kauzuaki Kanai, Shinichi Ueno, Tomoko Nakazato, Masashi Takanashi, Ryota Tanaka, Kazumasa Yokoyama, Kimiyoshi Arimura, Satoshi Kuwabara and Nobutaka Hattori

      Version of Record online: 1 AUG 2016 | DOI: 10.1111/cen3.12325

      Thumbnail image of graphical abstract

      We reported a case, 25 years old woman,Morvan syndrome who complicated with various neurological symptoms of myotonia, chronic pain, epilepsy, and ovarian tumor, with anti-Ma2/Ta antibodies.

  6. Images in Neuroimmunology

    1. Spinal cord open-ring enhancement in multiple sclerosis with marked effect of fingolimod

      Yoko Warabi, Tadashi Ozawa and Eiji Isozaki

      Version of Record online: 31 JUL 2016 | DOI: 10.1111/cen3.12322

      Thumbnail image of graphical abstract

      We report the case of a patient with multiple sclerosis who had spinal cord lesions relapsing as many as eight times in 3 years. Fingolimod was markedly efficacious for frequently relapsing spinal cord lesions with open-ring enhancement. The marked effect of fingolimod on the present patient should be examined further to determine whether the efficacy of fingolimod differs depending on the site and size of lesions, and the enhancement pattern of lesions on magnetic resonance imaging.

  7. Research Notes

    1. P2Y12 expression on microglia in the human brain

      Jun-ichi Satoh, Youhei Tosaki, Kenji Sakai, Motoaki Yanaizu and Yoshihiro Kino

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/cen3.12320

      Thumbnail image of graphical abstract

      P2Y12 expressed on ramified and amoeboid microglia in the human brain. P2Y12 is not expressed on perivascular macrophages. P2Y12-immunoreactive ramified microglia are not polarized to M1 or M2 in NHD brains.


  1. 1 - 11