Biology of the Cell

Cover image for Vol. 106 Issue 8

Edited By: Thierry Galli, Paris, France

Impact Factor: 3.872

ISI Journal Citation Reports © Ranking: 2013: 78/185 (Cell Biology)

Online ISSN: 1768-322X

Highlights

  • DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling

    DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling

    DLK1 and 2 proteins are expressed in submandibular salivary gland (SMG) development, and DLK1 inhibits NOTCH activity. SMG branching was reduced in the presence or NOTCH inhibitory agents, either soluble DLK1 (sDLK1) or DAPT, and impaired innervation of the epithelial end buds. SMG innervation was restored by the acetylcholine analog carbachol, which also rescued cytokeratin 5 (CK5+)-expressing epithelial progenitor cells. It improved recovery of branching morphogenesis in SMGs, once DLK1 or DAPT were removed from the medium. In conclusion, DLK1 regulates SMGs morphogenesis and parasympathetic nerve fibre outgrowth through inhibition of NOTCH signalling.

  • Recruitment of HP1β to UVA-induced DNA lesions is independent of radiation-induced changes in A-type lamins

    Recruitment of HP1β to UVA‐induced DNA lesions is independent of radiation‐induced changes in A‐type lamins

    We found that UVA irradiation of nuclear lamina in defined regions destroyed A-type lamins after 5–10 min. However, UVA irradiation did not affect the recruitment of HP1β, 53BP1 and BMI1 to DNA lesions, but the pattern of 53BP1 was different in irradiated regions. After -irradiation, the nuclear lamina remained intact and the level of HP1β was stable, but DNA injury changed 53BP1 levels in A-type lamin-deficient cells. Together, only the 53BP1 pattern in DNA lesions is affected by A-type lamin deficiency, which was not observed for heterochromatin-related proteins HP1β and BMI1.

  • H2B ubiquitylation modulates spliceosome assembly and function in budding yeast

    H2B ubiquitylation modulates spliceosome assembly and function in budding yeast

    Splicing occurs co-transcriptionally for the vast majority of intron-containing genes in the yeast Saccharomyces cerevisiae. Here, we analysed the contribution of transcription-dependent chromatin marks on spliceosome assembly and function on nascent transcripts and found that multiple histone modifications, and in particular Ub-H2B, are required for optimal spliceosome function at distinct subsets of genes.

  • REVIEW: Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle

    REVIEW: Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle

    Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and high fidelity. A core element of this machinery is the kinesin-5 motor protein, which plays essential roles in spindle formation and maintenance. In this review, we discuss how the structural and mechanical properties of kinesin-5 motors uniquely suit them to their mitotic role. We describe some of the small molecule inhibitors and regulatory proteins that act on kinesin-5, and discuss how these regulators may influence the process of cell division. Finally, we touch on some more recently described functions of kinesin-5 motors in non-dividing cells. Throughout, we highlight a number of open questions that impede our understanding of both this motor's function and the potential utility of kinesin-5 inhibitors.

  • DLK1 regulates branching morphogenesis and parasympathetic innervation of salivary glands through inhibition of NOTCH signalling
  • Recruitment of HP1β to UVA‐induced DNA lesions is independent of radiation‐induced changes in A‐type lamins
  • H2B ubiquitylation modulates spliceosome assembly and function in budding yeast
  • REVIEW: Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle

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Announcing...

Paper & Cover of the Year 2013 have been chosen!

cover of the year 2013

Cover of the Year 2013 has been awarded to Albert Neutzner and colleagues for the cover of Issue 7
showing "fluorescently-labeled S. aureus (green) taken up by MEC (red - rhodamin-phalloidin labeling of actin skeleton)".

Paper of the Year 2013 has been awarded to Jean Gruenberg and colleagues for:
PNPLA3/adiponutrin functions in lipid droplet formation
Zeina Chamoun, Fabrizio Vacca, Robert G. Parton and Jean Gruenberg


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July 2014
Revelation of fibroblast protein commonalities and differences and their possible roles in wound healing and tumourigenesis using co-culture models of cells
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  • 2013 Impact Factor: 3.872
  • 2013 5-year Impact Factor: 4.417
  • 2013 Eigenfactor score: 0.00671
  • 2013 Immediacy Index: 0.795
  • 2013 Article Influence score: 1.658




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