Journal of Diabetes Investigation

Cover image for Vol. 7 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Nigishi Hotta

Impact Factor: 2.294

ISI Journal Citation Reports © Ranking: 2015: 90/133 (Endocrinology & Metabolism)

Online ISSN: 2040-1124

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  1. 1 - 43
  1. Original Articles

    1. You have full text access to this OnlineOpen article
      Nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes

      Misako Okuno, Yoshihito Kasahara, Masafumi Onodera, Noriyuki Takubo, Michiko Okajima, Shigeru Suga, Nobuyuki Watanabe, Junichi Suzuki, Tadayuki Ayabe, Tatsuhiko Urakami, Tomoyuki Kawamura, Nobuyuki Kikuchi, Ichiro Yokota, Toru Kikuchi, Shin Amemiya, Kazuhiko Nakabayashi, Keiko Hayashi, Kenichiro Hata, Yoichi Matsubara, Tsutomu Ogata, Maki Fukami and Shigetaka Sugihara

      Version of Record online: 25 NOV 2016 | DOI: 10.1111/jdi.12586

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      We identified nucleotide substitutions of CD101, an autoimmune diabetes gene in the NOD mouse, in familial and sporadic cases of type 1 diabetes. Fluorescence-activated cell sorting analysis demonstrated that CD101 expression on monocytes, granulocytes, and myeloid dendritic cells of mutation-positive patients was weaker than that of control individuals. These results raise the possibility that CD101 is a novel susceptibility gene for type 1 diabetes.

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      Analysis of the association between glucose profiles and β-cell function for diabetic cardiovascular autonomic neuropathy in China

      Ping Fang, Jingcheng Dong, Fangfang Zeng and Zihui Tang

      Version of Record online: 25 NOV 2016 | DOI: 10.1111/jdi.12584

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      In this study, we investigate the extent of associations of glucose profiles, beta cell function and its severity with DCAN in Chinese population. More importantly, in this study, we first used glucose profiles risk score to evaluate the severity of glucose profiles and beta cell function. These suggested glucose profile and beta cell function may influence the progression of DCAN and also provided insight into biological functions.

  2. Short Reports

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      Preventive effect of ipragliflozin on nocturnal hypoglycemia in patients with type 2 diabetes treated with basal-bolus insulin therapy: An open-label, single-center, parallel, randomized control study

      Fumitaka Okajima, Tomoko Nagamine, Yuko Nakamura, Naomi Hattori, Hitoshi Sugihara and Naoya Emoto

      Version of Record online: 25 NOV 2016 | DOI: 10.1111/jdi.12588

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      The administration of ipragliflozin with or without teneligliptin reduced the incidence of nocturnal hypoglycemia in type 2 diabetic patients with basal-bolus insulin therapy at the end of hospitalization for glycemic control.

    2. You have full text access to this OnlineOpen article
      Advanced glycation end-products are a risk for muscle weakness in Japanese patients with type 1 diabetes

      Hiroyasu Mori, Akio Kuroda, Michiko Araki, Reiko Suzuki, Satoshi Taniguchi, Motoyuki Tamaki, Yuko Akehi and Munehide Matsuhisa

      Version of Record online: 23 NOV 2016 | DOI: 10.1111/jdi.12582

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      The purpose of this study is to investigate the relationship between AGE accumulations, sarcopenia and muscle function of patients with type 1 diabetes. We found that impaired muscle function in lower limb was highly observed in type 1 diabetes, and was associated with accumulation of AGE.

  3. Clinical Trials

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      Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function

      Fumika Shigiyama, Naoki Kumashiro, Masahiko Miyagi, Ryo Iga, Yuka Kobayashi, Eiichiro Kanda, Hiroshi Uchino and Takahisa Hirose

      Version of Record online: 21 NOV 2016 | DOI: 10.1111/jdi.12587

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      Linagliptin for 16 weeks improved endothelial function with a modest improvement in glycemic control. This effect was mediated, at least in part, by reduction in apolipoprotein B. Linagliptin has a protective role on endothelial function in patients with type 2 diabetes with moderate hyperglycemia.

  4. Original Articles

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      Ghrelin is a possible new predictor associated with executive function in patients with type 2 diabetes mellitus

      Siting Chen, Xuyang Zuo, Yuan Li, Tian Jiang, Nan Zhang, Fang Dai, Qiaoer Chen and Qiu Zhang

      Version of Record online: 15 NOV 2016 | DOI: 10.1111/jdi.12580

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      The level of serum ghrelin might be a biomarker of executive function and become a strong predictor of executive function impairment in patients with type 2 diabetes mellitus. Ghrelin might have a potential protective effect against cognitive function impairment in type 2 diabetic patients.

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      Adiponectin and pro-inflammatory cytokines are modulated in Vietnamese patients with type 2 diabetes mellitus

      Hoang Van Tong, Nguyen Kim Luu, Ho Anh Son, Nguyen Van Hoan, Trinh Thanh Hung, Thirumalaisamy P Velavan and Nguyen Linh Toan

      Version of Record online: 30 OCT 2016 | DOI: 10.1111/jdi.12579

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      Type 2 diabetes mellitus (T2DM), tumor necrosis factor-α (TNF-α), Interleukin-1 beta (IL-1β). and Interleulin 10 (IL-10).

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      Neck circumference might predict gestational diabetes mellitus in Han Chinese women: A nested case–control study

      Fang He, Hua He, Wenqi Liu, Junyu Lin, Bingjun Chen, Yucong Lin, Yitao Zhao, Wen Tao and Xuefeng Xia

      Version of Record online: 17 OCT 2016 | DOI: 10.1111/jdi.12574

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      Neck circumference is a viable tool to screen for GDM. The optimal neck circumference cutoff in pregnant women for predicting GDM was 35.15 cm in this population of Chinese women.

  5. Clinical Trials

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      Vildagliptin reduces plasma stromal cell-derived factor-1α in patients with type 2 diabetes compared with glimepiride

      Kyeong Seon Park, SooHeon Kwak, Young Min Cho, Kyong Soo Park, Hak C Jang, Seong Yeon Kim and Hye Seung Jung

      Version of Record online: 12 OCT 2016 | DOI: 10.1111/jdi.12572

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      Compared to glimepiride, vildagliptin arrestingly decreased plasma SDF-1a, and its clinical implications should be further investigated.

    2. You have full text access to this OnlineOpen article
      Insulin degludec/insulin aspart vs biphasic insulin aspart 30 twice daily in Japanese patients with type 2 diabetes: A randomized controlled trial

      Yukiko Onishi, Kenichi Yamada, Jeppe Zacho, Jan Ekelund and Yasuhiko Iwamoto

      Version of Record online: 7 OCT 2016 | DOI: 10.1111/jdi.12569

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      This exploratory trial investigated the safety of switching unit-to-unit from twice-daily basal or pre-mix insulin to twice-daily insulin degludec/insulin aspart (IDegAsp) in Japanese patients with type 2 diabetes. IDegAsp, as compared with biphasic insulin aspart 30 (BIAsp 30), was not associated with any safety concerns and appears to represent an effective and well tolerated treatment option in Japanese patients with type 2 diabetes.

    3. You have full text access to this OnlineOpen article
      Impact of diet on the efficacy of insulin lispro mix 25 and insulin lispro mix 50 as starter insulin in East Asian patients with type 2 diabetes: Subgroup analysis of the Comparison Between Low Mixed Insulin and Mid Mixed Insulin as Starter Insulin For Patients with Type 2 Diabetes Mellitus (CLASSIFY Study) randomized trial

      Wei Chen, Lei Qian, Hirotaka Watada, Peng Fei Li, Noriyuki Iwamoto, Makoto Imori and Wen Ying Yang

      Version of Record online: 5 OCT 2016 | DOI: 10.1111/jdi.12547

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      Diet plays an important role when tailoring anti-diabetic treatment, however the evidence is little from randomized clinical trial. In this study, we found both LM25 and LM50 improved Glycemic control in East Asian with T2DM, but LM50 was significantly more efficacious under certain dietary conditions, particularly with increased carbohydrate intake.

  6. Original Articles

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      Sudoscan is an effective screening method for asymptomatic diabetic neuropathy in Chinese type 2 diabetes mellitus patients

      Fei Mao, Siying Liu, Xiaona Qiao, Hangping Zheng, Qian Xiong, Jie Wen, Lianyong Liu, Mingming Tang, Shuo Zhang, Zhaoyun Zhang, Hongying Ye, Bin Lu and Yiming Li

      Version of Record online: 5 OCT 2016 | DOI: 10.1111/jdi.12575

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      The aim of this study was to use the sudomotor function test, SUDOSCAN, as a screening method for the evaluation of asymptomatic diabetic distal symmetric polyneuropathy(DSPN)in Chinese type 2 diabetic patients, and thus more attention could be paid to those asymptomatic patients who could be easily neglected and underdiagnosed in everyday clinic. A total of 394 Chinese type 2 diabetic patients were enrolled and tested for symptoms and clinical signs of neuropathy using Neurological Symptom Score (NSS), Neuropathy Disability Score (NDS); and SUDOSCAN was performed.In this study, we found that the abnormal rate of SUDOSCAN results in patients with asymptomatic neuropathy was higher than those without neuropathy and those with symptomatic neuropathy.SUDOSCAN may be a promising tool to screen asymptomatic diabetic distal symmetric polyneuropathy in Chinese patients with type 2 diabetes mellitus (T2DM). *P < 0.01

  7. Commentary

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      Cardiovascular safety trials of incretin-based drugs: What do they mean?

      Daisuke Yabe and Yutaka Seino

      Version of Record online: 5 OCT 2016 | DOI: 10.1111/jdi.12576

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      Results of EXAMINE, TECOS and ELIXA encourage neutral CV safety profiles of incretin-based drugs in individuals with type 2 diabetes and established CV diseases or multiple CV risks; the heart failure findings of SAVOR-TIMI53 are unexpected and very concerning. Moreover, LEADER results demonstrate benefits of liraglutide on preventing CV events in a similar study population.

    2. You have full text access to this OnlineOpen article
      Where does liver fat go? A possible molecular link between fatty liver and diabetes

      Akihiro Kikuchi and Toshinari Takamura

      Version of Record online: 5 OCT 2016 | DOI: 10.1111/jdi.12573

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      An elevation of fatty acid delivery amplifies the TCA cycle flux with a rise in anaplerosis/cataplerosis, leading to a proportional rise in oxidative stress and inflammation in liver.

  8. Editorial

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      Integration of diffusion of innovation theory into diabetes care

      Angela Shin-Yu Lien and Yi-Der Jiang

      Version of Record online: 30 SEP 2016 | DOI: 10.1111/jdi.12568

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      The acceptance for innovation by Rogers

  9. Original Articles

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      Effect of a newly-devised nutritional guide based on self-efficacy for patients with type 2 diabetes in Japan over 2 years: 1-year intervention and 1-year follow-up studies

      Takuya Yamamoto, Shota Moyama and Hideki Yano

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/jdi.12571

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      We devised a new compilation called “Educational Guidance” (E-Guide) for education on nutrition based on self-efficacy. The intervention based on our “E-Guide” may be more useful and powerful than the conventional methods for glycemic control and self-care behavior among patients with type 2 diabetes in Japan.

    2. You have full text access to this OnlineOpen article
      Effects of yoga in adults with type 2 diabetes mellitus: A meta-analysis

      Jie Cui, Jun-Hong Yan, Li-Ming Yan, Lei Pan, Jia-Jin Le and Yong-Zhong Guo

      Version of Record online: 19 SEP 2016 | DOI: 10.1111/jdi.12548

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      The aim of the present meta-analysis of the existing data is to quantitatively assess the role of yoga in patients with T2DM. The available evidence from 12 RCTs with a total of 864 patients suggested that yoga can significantly decrease patient FBG, PPBG, HbA1c, TC, and LDL-C levels and increases their HDL-C.

    3. You have full text access to this OnlineOpen article
      Prescription of oral hypoglycemic agents for patients with type 2 diabetes mellitus: A retrospective cohort study using a Japanese hospital database

      Makito Tanabe, Ryoko Motonaga, Yuichi Terawaki, Takashi Nomiyama and Toshihiko Yanase

      Version of Record online: 15 SEP 2016 | DOI: 10.1111/jdi.12567

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      The article showed the prescription pattern of oral hypoglycemic agents for Japanese pateients with type-2 diabetes.

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      Donor liver steatosis: A risk factor for early new-onset diabetes after liver transplantation

      Mengjuan Xue, Chaoyang Lv, Xianying Chen, Jing Liang, Chenhe Zhao, Yao Zhang, Xiaowu Huang, Qiman Sun, Ting Wang, Jian Gao, Jian Zhou, Mingxiang Yu, Jia Fan and Xin Gao

      Version of Record online: 11 SEP 2016 | DOI: 10.1111/jdi.12560

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      The retrospective cohort study found a high cumulative incidence of NODAT in liver transplant recipients. Donor liver steatosis is a factor risk for NODAT.

  10. Commentary

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      Glucose- or insulin resistance-mediated β-cell replication: PKCζ integrates the proliferative signaling

      Jun Shirakawa and Yasuo Terauchi

      Version of Record online: 11 SEP 2016 | DOI: 10.1111/jdi.12558

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      Glucose- or insulin resistance-mediated β-cell replication serves as a useful physiological model of β-cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β-cell proliferation induced by glucose stimulation or high-fat diet-feeding.

  11. Original Articles

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    2. You have full text access to this OnlineOpen article
      Deoxyribonucleic acid telomere length shortening can predict the incidence of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus

      Fan Ping, Zeng-yi Li, Ke Lv, Mei-cen Zhou, Ya-xiu Dong, Qi Sun and Yu-xiu Li

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/jdi.12555

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      (i) Telomere shortening was the independent predictive factor of NAFLD in T2DM. (ii) Dyslipidemia was more like the consequence rather than the pathogenesis of NAFLD. (iii) Adds the evidence of interaction between DNA telomere length shortening as well as insulin resistance and NAFLD in T2DM.

  12. Commentary

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      Salt and sugar: Bad company

      Jun Wada

      Version of Record online: 30 AUG 2016 | DOI: 10.1111/jdi.12553

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      This report shed light to unrecognized mechanism for the hyperglycemia-induced sodium retention. The activation of PPAR?, elevation of serum adiponectin, and subsequent inhibition of SGLT2 may lead to natriuresis and glycosuria and it may be beneficial in hypertensive diabetic patients.

  13. Original Articles

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      Reported prevalence of gestational diabetes in Scotland: The relationship with obesity, age, socioeconomic status, smoking and macrosomia, and how many are we missing?

      Andrew Collier, E Christie Abraham, Julie Armstrong, Jon Godwin, Kirsten Monteath and Robert Lindsay

      Version of Record online: 27 AUG 2016 | DOI: 10.1111/jdi.12552

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      The study confirms the association between GDM and BMI, maternal age, parity and social deprivation. The study demonstrates a negative association with smoking and (after multivariate analysis), no association between GDM and macrosomia. This anomaly probably reflects problems with the screening process for GDM in Scotland and probably elsewhere in UK and Europe.

    2. You have full text access to this OnlineOpen article
      Urotensin II inhibits autophagy in renal tubular epithelial cells and induces extracellular matrix production in early diabetic mice

      Guan-Jong Chen, Fei Wu, Xin-Xin Pang, Ai-Hua Zhang, Jun-Bao Shi, Min Lu and Chao-Shu Tang

      Version of Record online: 25 AUG 2016 | DOI: 10.1111/jdi.12557

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      Urotensin II (UII) and autophagy have been considered as important components in the pathogenesis of diabetic nephropathy. The present study explores whether UII can regulate autophagy in kidney and its effect in diabetes.

  14. Short Reports

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      Brachial-ankle pulse wave velocity, but not ankle-brachial index, predicts all-cause mortality in patients with diabetes after lower extremity amputation

      Kazuki Ikura, Ko Hanai, Seiji Oka, Makiko Watanabe, Yuri Oda, Mariko Hamada, Yuka Kato, Takamichi Shinjyo and Yasuko Uchigata

      Version of Record online: 25 AUG 2016 | DOI: 10.1111/jdi.12554

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      This was an observational historical cohort study of 102 Japanese diabetic patients after first non-traumatic lower extremity amputation (LEA). Brachial-ankle pulse wave velocity (baPWV), but not ankle-brachial pressure index (ABI), may be a predictor for all-cause mortality in diabetic patients after LEA.

  15. Clinical Trials

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      Factors influencing inter-day glycemic variability in diabetic outpatients receiving insulin therapy

      Hiroko Mori, Yosuke Okada, Akira Kurozumi, Manabu Narisawa and Yoshiya Tanaka

      Version of Record online: 18 AUG 2016 | DOI: 10.1111/jdi.12551

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      The results suggest that patients with large inter-day glycemic variability are unlikely to achieve improvement in HbA1c level. Treatment and instructions based on patient's characteristics, day-to-day glycemic variability and lifestyle are important to achieve good glycemic control.

  16. Original Articles

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      Duration of diabetes and types of diabetes therapy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention prospective study 3 (JDCP study 3)

      Yasuaki Hayashino, Kazuo Izumi, Shintaro Okamura, Rimei Nishimura, Hideki Origasa, Naoko Tajima and for the JDCP study group

      Version of Record online: 10 AUG 2016 | DOI: 10.1111/jdi.12550

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      Odds ratio curve for the association between linearly increasing duration of diabetes and odds of any insulin therapy in patients with type 2 diabetes. Solid lines indicate odds ratios for insulin therapy as obtained by restricted cubic spline logistic regression with knots placed at fixed values (5th, 25th, 75th, and 95th percentiles of the distribution of serum uric acid), and the dotted lines indicate their 95% confident intervals.

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      Analysis of risk factors and their interactions in type 2 diabetes mellitus: A cross-sectional survey in Guilin, China

      Disha Zou, Yao Ye, Nina Zou and Jian Yu

      Version of Record online: 9 AUG 2016 | DOI: 10.1111/jdi.12549

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      The study is a cross-sectional survey of type 2 diabetes in Guilin, China.The study aimed to not only analyze the influence of single factor for type 2 diabetes, but also investigate the interaction effects between risk factors.

  17. Review Articles

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      Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities

      Toshitaka Umemura, Takahiko Kawamura and Nigishi Hotta

      Version of Record online: 3 AUG 2016 | DOI: 10.1111/jdi.12545

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      Previous studies suggest that diabetes atherosclerosis has similarities with diabetic microangiopathy and may partly develop from the metabolic cascade activated via hyperglycemia-induced polyol pathway hyperactivity. As retinal microvascular abnormalities are associated with neuroimaging markers of cerebral small vessel disease, polyol pathway hyperactivity might be a possible mechanism for the development and progression of cerebral small vessel disease in diabetic patients.

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      Pharmacokinetic and pharmacodynamic evaluation of linagliptin for the treatment of type 2 diabetes mellitus, with consideration of Asian patient populations

      Antonio Ceriello and Nobuya Inagaki

      Version of Record online: 21 JUL 2016 | DOI: 10.1111/jdi.12528

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      Linagliptin is pharmacologically distinct from other dipeptidyl-peptidase (DPP)-4 inhibitors currently available for the treatment of type 2 diabetes (T2DM). While most agents in its class are excreted in the urine and require dose adjustment for patients with renal impairment, dose adjustment is not necessary for linagliptin. The 5 mg dose of linagliptin is suitable for patients with T2DM irrespective of their ethnicity or the presence of renal or hepatic impairment.

  18. Original Articles

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      Elevated expression levels of serum insulin-like growth factor-1, tumor necrosis factor-α and vascular endothelial growth factor 165 might exacerbate type 2 diabetic nephropathy

      Xiang Li, Ting-Ting Wu, Juan Chen and Wen Qiu

      Version of Record online: 15 JUL 2016 | DOI: 10.1111/jdi.12542

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      This study aimed to determine the associations between expressions of Insulin-like Growth Factor-1 (IGF-1), Tumor Necrosis Factor-? (TNF-?) and vascular endothelial growth factor (VEGF) in serum, and occurrence and development of type 2 diabetic nephropathy (DN).

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      Varenicline in smokers with diabetes: A pooled analysis of 15 randomized, placebo-controlled studies of varenicline

      Serena Tonstad and David Lawrence

      Version of Record online: 14 JUL 2016 | DOI: 10.1111/jdi.12543

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      This was a retrospective pooled analysis including data from 15 randomized, placebo controlled trials of varenicline in smokers of ≥10 cigarettes/day with diabetes. Varenicline was an effective and well-tolerated aid for smoking cessation in individuals with diabetes.

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      Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes

      Jingyi Lu, Yi Luo, Jie Wang, Cheng Hu, Rong Zhang, Congrong Wang and Weiping Jia

      Version of Record online: 9 JUL 2016 | DOI: 10.1111/jdi.12546

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      This study evaluated the peripheral nerve function in 1,900 patients with T2DM and genotyped ten T2DM susceptibility loci. rs5219 of KCNJ11 was observed to be significantly associated with the peripheral nerve function.

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      Mild hyperglycemia triggered islet function recovery in streptozotocin-induced insulin-deficient diabetic rats

      Yu Cheng, Jing Shen, Weizheng Ren, Haojie Hao, Zongyan Xie, Jiejie Liu, Yiming Mu and Weidong Han

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/jdi.12540

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      Our presented data supported that moderated elevated glucose level stimulated beta cell proliferation in insulin-deficient diabetic model, resulting in almost fully recovery of diabetes. Findings in this paper offered a feasible approach to promote beta cell regeneration.

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      Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once-weekly dipeptidyl peptidase-4 inhibitor, in healthy Japanese men

      Saori Tsuchiya, Evan Friedman, Carol Addy, Akira Wakana, Daniel Tatosian, Yuki Matsumoto, Hideyo Suzuki and Eunkyung Kauh

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/jdi.12538

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      Omarigliptin is a novel, potent, long-acting oral dipeptidyl peptidase-4 (DPP-4) inhibitor being developed as a once-weekly (q.w.) treatment for type 2 diabetes (T2DM) patients, with 25 mg and 12.5 mg tablets recently being approved as market formulations in Japan. We evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of omarigliptin in healthy Japanese male subjects after single and multiple dose administration. Omarigliptin was well tolerated and had a pharmacokinetic and DPP-4 inhibition profile that supports once-weekly dosing in Japanese patients with T2DM.

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      High neutrophil-to-lymphocyte ratio is associated with increased carotid artery intima-media thickness in type 2 diabetes

      Xueqin Li, Jun Shen, Zhenghong Lu, Min Chen, Xiaozheng Fang and Gongcheng Wang

      Version of Record online: 3 JUL 2016 | DOI: 10.1111/jdi.12541

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      In this study, we investigate the role of NLR in cIMT development among type 2 diabetic patients, and our results succeed for the first time in indicating that the mean NLR is significantly higher in the group of DM-High cIMT than group of DM-Low cIMT. High NLR may be a potential biomarker for the increased cIMT in T2DM

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      Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro

      Xu-Peng Mu, Li-Qun Ren, Hao-Wei Yan, Xin-Min Zhang, Tian-Min Xu, An-Hui Wei and Jin-Lan Jiang

      Version of Record online: 30 JUN 2016 | DOI: 10.1111/jdi.12544

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      Human amniotic fluid stem cells were successfully isolated from amniotic fluid. Human amniotic fluid stem cells under selective culture conditions differentiated into islet-like insulin-producing cells.

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      Specific types of alcoholic beverage consumption and risk of type 2 diabetes: A systematic review and meta-analysis

      Jin Huang, Xiuling Wang and Yadong Zhang

      Version of Record online: 17 JUN 2016 | DOI: 10.1111/jdi.12537

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      We explored the relationship between specific types of alcoholic beverage and the incidence of type 2 diabetes. We reported for the first time that wine consumption was associated with a more significant decreased risk of type 2 diabetes compared with beer or spirits. We concluded that wine may be more helpful for protection against type 2 diabetes than beer or spirits.

  19. Review Articles

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      Clinical predictive factors in diabetic kidney disease progression

      Nicholas J Radcliffe, Jas-mine Seah, Michele Clarke, Richard J MacIsaac, George Jerums and Elif I Ekinci

      Version of Record online: 8 JUN 2016 | DOI: 10.1111/jdi.12533

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      Diabetic Kidney Disease represents a major component of the health burden associated with type 1 and type 2 diabetes. This article summarises clinical variables associated with the progression of Diabetic Kidney Disease; a brief discussion is also made of promising ‘novel’ biomarkers which may eventually become readily available to the practicing clinician.

  20. Editorial

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  21. Commentary

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      Novel mechanism for counter-regulatory responses to hypoglycemia

      Tatsuhito Himeno and Jiro Nakamura

      Version of Record online: 12 MAY 2016 | DOI: 10.1111/jdi.12527

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      In the central nervous system, especially in the hypothalamus, the energy status in the body is assessed by glucose-sensing neurons since glucose is the major fuel in the central nervous system. Glucose sensing mechanisms also have a significant role in prevention of hypoglycemic bouts. In a recent report, Fan and colleagues proved a novel type of glucose-exited neurons which detect hypoglycemia through decreasing glucose entry via SGLT1.

  22. Editorial

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      Continuous glucose monitoring in China: Then, now and in the future

      Weiping Jia

      Version of Record online: 11 MAY 2016 | DOI: 10.1111/jdi.12521

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      Glucose monitoring is a key component in assessing glucose metabolic disturbance, evaluating therapeutic outcomes and guiding treatment regimens. For decades, continuous glucose monitoring (CGM) was one of the dreams of patients with diabetes and diabetologists. In this article, the research progress, opportunities and challenges of the use of CGM technology are reviewed.

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