Nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes
Misako Okuno, Yoshihito Kasahara, Masafumi Onodera, Noriyuki Takubo, Michiko Okajima, Shigeru Suga, Nobuyuki Watanabe, Junichi Suzuki, Tadayuki Ayabe, Tatsuhiko Urakami, Tomoyuki Kawamura, Nobuyuki Kikuchi, Ichiro Yokota, Toru Kikuchi, Shin Amemiya, Kazuhiko Nakabayashi, Keiko Hayashi, Kenichiro Hata, Yoichi Matsubara, Tsutomu Ogata, Maki Fukami and Shigetaka Sugihara
Version of Record online: 25 NOV 2016 | DOI: 10.1111/jdi.12586
We identified nucleotide substitutions of CD101, an autoimmune diabetes gene in the NOD mouse, in familial and sporadic cases of type 1 diabetes. Fluorescence-activated cell sorting analysis demonstrated that CD101 expression on monocytes, granulocytes, and myeloid dendritic cells of mutation-positive patients was weaker than that of control individuals. These results raise the possibility that CD101 is a novel susceptibility gene for type 1 diabetes.