Pathogens and Disease
© Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved
Edited By: Patrik M. Bavoil
Impact Factor: 2.554
ISI Journal Citation Reports © Ranking: 2013: 36/70 (Infectious Diseases); 55/119 (Microbiology); 80/144 (Immunology)
Online ISSN: 2049-632X
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This minireview offers a perspective on the role of the interplay between host signaling pathways – specifically the IkB kinase complex pathway – and viral infections. Since this interplay is often necessary for viral replication and results in immune activation, inflammation and other negative consequences for the host, it becomes an attractive target for therapy.
Highlighted Short Communication Open Access
We used the novel approach of transformation combined with recombination to identify the region of the chlamydial plasmid that determines tropism, it demonstrates the barrier is at the level of plasmid replication/maintenance and is not related to the process of DNA uptake.
Editor Choice: Peter Timms
CPAF: questions & directions
One protein in particular has dominated the field of chlamydial cell biology in the last 5 or so years, CPAF, the so called Chlamydial Protease-like Activity Factor. This unique chlamydial cysteine protease has been associated wide a wide range of activities, potentially regulating many host cell functions. While some of its activities are confirmed, others have been questioned. Several expert chlamydial researchers who have contributed to this important area have provided commentaries on CPAF in this issue; what is known, what might be misleading and what needs to be done now.