Pathogens and Disease

Microbial Communities in Infection and Disease

Lactobacillus rhamnosus GG protection against human rotavirus-induced diarrhea

This article deals with an important topic in mucosal immunology - the mechanism of activity by which probiotics protect against rotavirus (RV)-induced diarrhea. The data shows that in an animal model, administration of Lactobacillus rhamnosus GG (LGG) is associated with higher levels of soluble IgA, and modulation of production of cytokines IFN-[gamma] and TNF-α is observed. These findings may contribute to improve prevention and treatment of RV-induced diarrhea in humans.

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Molecular Pathogenesis

Chlamydia trachomatis plasmid CDS6 regulates inclusion phenotype

This is a short, definitive manuscript which applies new DNA transformation technologies to Chlamydia to address the function of plasmid genes in glycogen metabolism.

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In Chlamydia Veritas

Chief Editor Patrik Bavoil

Molecular Pathogenesis

Pseudomonas aeruginosa: new insights into pathogenesis and host defenses

This review describes the two main types of P. aeruginosa lung infections and provides an overview of the host response and how the genomic capacity of P. aeruginosa contributes to the pathogenesis and persistence of these infections.

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Host Responses to Infection

Autophagy in mycobacterial infection

The authors review the triggers, host factors, and intracellular pathways that regulate host autophagy and its impact on antimicrobial host defenses during mycobacterial infection.

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