Pathogens and Disease

Cover image for Vol. 72 Issue 1

Edited By: Patrik M. Bavoil

Impact Factor: 2.554

ISI Journal Citation Reports © Ranking: 2013: 36/70 (Infectious Diseases); 55/119 (Microbiology); 80/144 (Immunology)

Online ISSN: 2049-632X

Associated Title(s): FEMS Microbiology Ecology, FEMS Microbiology Letters, FEMS Microbiology Reviews, FEMS Yeast Research

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Highlighted MiniReview

Role of IKK complex in viral infections

Role of IKK complex in viral infectionsThis minireview offers a perspective on the role of the interplay between host signaling pathways – specifically the IkB kinase complex pathway – and viral infections. Since this interplay is often necessary for viral replication and results in immune activation, inflammation and other negative consequences for the host, it becomes an attractive target for therapy.

Highlighted Short Communication Open Access

Tropism of the C. trachomatis plasmid is determined by CDS2

Tropism of the C. trachomatis plasmid is determined by CDS2
We used the novel approach of transformation combined with recombination to identify the region of the chlamydial plasmid that determines tropism, it demonstrates the barrier is at the level of plasmid replication/maintenance and is not related to the process of DNA uptake.

Open Access Pathogens and Disease


Editor Choice: Peter Timms

CPAF: questions & directions

CPAF: questions & directions

One protein in particular has dominated the field of chlamydial cell biology in the last 5 or so years, CPAF, the so called Chlamydial Protease-like Activity Factor. This unique chlamydial cysteine protease has been associated wide a wide range of activities, potentially regulating many host cell functions. While some of its activities are confirmed, others have been questioned. Several expert chlamydial researchers who have contributed to this important area have provided commentaries on CPAF in this issue; what is known, what might be misleading and what needs to be done now.

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