Pathogens and Disease

Cover image for Vol. 72 Issue 3

A proteomics view at pathogenicity

  A proteomics view at pathogenicity

Microbial pathogens interact and respond to their eukaryotic hosts in many different ways that can be comprehensively visualized using 'omic methodologies. Proteomics, the large scale study of the complete complement of proteins of an organism (or a subcellular fraction thereof) have recently evolved to highly sensitive mass-spectrometry-based analyses that are ideal to not only identify the proteins but also to dissect structure-function relationships that are critical for virulence. The articles in this thematic issue highlight this evolution with examples of proteomic analyses in viruses, bacteria and fungi.

Deciphering the Leishmania exoproteome: what we know and what we can learn
Rosa Milagros Corrales, Denis Sereno, Françoise Mathieu-Daudé

Proteomic analysis of Proteus mirabilis outer membrane proteins reveals differential expression in vivo vs. in vitro conditions
Bruno D'Alessandro, Leticia M. S. Lery, Wanda M. A. von Krüger, Analía Lima, Claudia Piccini, Pablo Zunino

Proteomic analysis of swine hepatitis E virus (sHEV)-infected livers reveals upregulation of apolipoprotein and downregulation of ferritin heavy chain
Garam Lee, Dongun Han, Jae-Young Song, Jae-Hoon Kim, Sorah Yoon

Time-course proteomic profile of Candida albicans during adaptation to a fetal serum
Wataru Aoki, Tomomi Ueda, Yohei Tatsukami, Nao Kitahara, Hironobu Morisaka, Kouichi Kuroda, Mitsuyoshi Ueda

Proteomic and metabolic characterization of a Candida albicans mutant resistant to the antimicrobial peptide MUC7 12-mer
Maciej Lis, Libuse A. Bobek

Analysis of proteins in Chlamydia trachomatis L2 outer membrane complex, COMC
Svend Birkelund, Marie Morgan-Fisher, Evy Timmerman, Kris Gevaert, Allan C. Shaw, Gunna Christiansen

Proteome-guided search for influenza A B-cell epitopes
Guglielmo Lucchese, Angela Stufano, Darja Kanduc