CA: A Cancer Journal for Clinicians
© American Cancer Society
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All CORRESPONDENCE for the journal should be sent to the following address. Please include the manuscript ID with all correspondence (example: CA-16-0000) when applicable:
CA: A Cancer Journal for Clinicians
American Cancer Society
250 Williams Street NW
Atlanta, GA 30303-1002 USA
Phone: (404) 327-6411
Fax: (404) 417-8016
CA: A Cancer Journal for Clinicians is a peer-reviewed journal published for the American Cancer Society by John Wiley & Sons, Inc. CA publishes comprehensive review articles of a multidisciplinary nature, which take into account the journal’s diverse readership of primary care physicians; medical, surgical, and radiation oncologists; nurses; and other health care and public health professionals. Articles published in CA provide up-to-date information on all aspects of cancer prevention, early detection, treatment of all forms, palliation, advocacy, quality of life, and more. Unsolicited manuscripts must meet pre-submission requirements.
The American Cancer Society is the nationwide community-based voluntary health organization dedicated to eliminating cancer as a major health problem by preventing cancer, saving lives, and diminishing suffering from cancer through research, education, advocacy, and service.
Note: Most CA articles are solicited reviews. With the exception of the American Cancer Society's Cancer Statistics articles, original research articles submitted for publication are generally not accepted for peer review. Case Reports and Letters to the Editor will not be considered for peer review or publication.
• Manuscripts must be submitted to CA via ScholarOne Manuscripts. Please contact the CA Editorial Office at (404) 327-6411 or firstname.lastname@example.org if you have any questions about submitting your manuscript online.
• All manuscripts must be submitted electronically using CA’s ScholarOne Manuscripts Web site available at mc.manuscriptcentral.com/ca. Manuscripts may not be submitted by e-mail.
• Submit text files only as .DOC, .DOCX, or .RTF file formats. Other file formats are not permitted and should be converted to .DOC or .DOCX.
• Authors are required to e-mail or upoload any permissions that may have been obtained for figures or tables or any permissions required for patient consent. Please include the permanent manuscript ID on all correspondence (example: CA-16-0000).
Pre-submission Requirements: Unsolicited Manuscripts
CA requires pre-submission correspondence (consisting of an outline and abstract describing the proposed article) for review by the Editors before any unsolicited manuscript can be submitted for peer review. All unsolicited manuscripts submitted without the Editor's approval of a pre-submission outline and abstract will be returned without review. Please e-mail an abstract, full author list, manuscript length, and information about the author to the Editorial Office for consideration (see Editorial Office contact information below).
Simultaneous Submission and Online Posting
CA will not consider papers that are simultaneously submitted elsewhere or have been published (to include online). If a manuscript is posted to an author’s Web site (or their institution’s site), it must be taken down prior to submission. Manuscripts cannot be posted online until after the paper has been published in CA and only if permission has been granted by the publisher and the article properly cited.
• Review Articles: These articles should be literature reviews of cancer types, therapeutic modalities or strategies (including palliative care), or important issues in cancer prevention or early detection. Manuscripts of this type should be 25 to 40 double-spaced pages in length including references. Articles on very rare cancer types and highly specialized information on individual drugs or procedures are generally not appropriate for CA.
• Editorials/Guest Editorials: Editorials are usually solicited; however, unsolicited editorials may be considered in some cases. Topics usually relate to the content of an article featured in the issue. Editorials are four to six double-spaced pages in length.
• Commentaries: Commentaries are usually solicited. They present a point of view of general interest to the CA audience.
• Department Articles: These articles cover current topics of interest to CA’s readership. Manuscripts should be 15 to 30 double-spaced pages in length. The length of solicited department articles will be addressed by the Editorial Office before submission. Departments include:
• Complementary & Alternative Methods (CAM) refers to products and regimens that individuals may employ either to enhance wellness, relieve symptoms of disease and side effects of conventional treatments, or cure disease. CAM articles provide evidence-based information on promising complementary and alternative methods, and inform clinicians of methods that may harm patients.
• Environmental Carcinogens articles deal with actual, potential, or perceived environmental and workplace carcinogens. Authors should highlight ways to advise patients about environmental exposures known or perceived to cause cancer by providing clear, concise information and advice that is based on laboratory and epidemiological research.
• Emerging Trends in Basic Science articles cover issues related to basic research (including molecular and cellular biology, epidemiology, immunology, radiation physics and biology, information technology, and related fields). They should be geared toward clinicians with limited time who want to remain up to date on advances in basic science research and the current and future clinical implications of that research.
• Perspectives: Research in Context is a section designed specifically for busy clinicians. It features practical, concise information that is accompanied by insight from noted experts in the fields of cancer prevention, detection, and treatment. This section is written in-house and external submissions are not accepted.
• Patient Pages are written to provide general information on specific topics for patients and caregivers. Patient Pages are usually related to the content of the particular issue in which they appear. Patient Pages may be photocopied and given directly to patients. This section is written in-house and external submissions are not accepted.
CA requires submission of an outline, which includes details on length, subject, authors (if available), and sponsorship information. Any supplement information that is received without the aforementioned items will be returned. This information must be provided for consideration by the Editors to determine appropriateness for CA's audience. All editorial materials, including supplements, are subject to peer review, and there is no guarantee of publication. All supplement costs must be borne by the authors or sponsoring group. Financial disclosures related to support should be provided in the cover letter. Copies of any related in-press publications should accompany manuscripts submitted to CA.
Manuscripts should follow the AMA Manual of Style (10th ed.)2 for grammar, punctuation, and style, and should meet the Uniform Requirements for Manuscripts Submitted to Biomedical Journals1 established by the ICMJE for general authorship guidelines.
The following items are required on the title page:
• Manuscript title.
• Running title: a short version of the title (up to 40 characters including spaces).
• Each author's name, academic degrees, and affiliation (all affiliations must be translated into standard English). Group members who do not meet the formal authorship criteria listed below but who contributed materially may be recognized in the Acknowledgments section.
• Complete mailing address, telephone, fax, and e-mail for correspondence and reprints.
• Total number of each: 1) text pages, including title page, references, and figure legends; 2) tables; and 3) figures.
• Details of all funding sources for the work in question. All financial and material support for the research and the work, including the source and number of grants for each author, should be listed. Please be sure to indicate whether any grants are from the NIH. If the work had no specific funding, this should be explicitly stated.
• All conflict of interest disclosures. If there are no financial disclosures from any authors, please state that as well.
• A dedicated Author Contributions section listing individual author contributions to the work. The contributions of all authors must be described. CA uses the CRediT taxonomy of contributor roles. Please note that Author Contribution Forms must be completed and submitted by every author upon acceptance.
• Articles must contain an abstract of approximately 200 words.
• Keywords: 4 to 10 key words or terms to be used as index terms. Use terms from the medical subject headings list of nlm.nih.gov/mesh.
Photographs With Identifiable Patients
In photographs, sonograms, CT scans, etc., the physical identification of a patient should be masked whenever possible. If a patient is identifiable, written permission to use the photograph must be obtained from the patient or guardian and sent to the CA Editorial Office upon manuscript submission. Clearly state in the manuscript that informed consent has been obtained.
Drugs and Devices
Use generic drug name (or generic name followed by trade name in parentheses). Include manufacturer and their location (city and country) for drugs and devices.
Use only standard abbreviations and spell out all abbreviations at first use in the text followed by the abbreviation in parentheses.1
Submit references per the following instructions:
• List references double-spaced in a separate reference section immediately following the text.
• Verify all references prior to submission.
• Use the AMA Manual of Style, 10th ed.1 for reference format style and List of Serials Indexed for Online Users11 for standard journal abbreviations (examples to follow).
• Number references sequentially in the order cited in the text; do not alphabetize. Remove automatic numbering and linked citations; number references manually.
• Do not cite personal communications, unpublished observations, and submitted manuscripts. Reference to a paper accepted but not yet published can be listed as ‘‘in press.’’ ‘‘In press’’ references must be updated by the authors as soon as publication data are available.
• Provide names of all authors in a reference when there are six or fewer; if there are seven or more authors, list only the first three, followed by ‘‘et al.’’
• References must be current. Use of references more than 10 years old is discouraged unless they are classic or unique works.
• Reference types. Following are requirements and examples for common reference types:
• Journal references include the specified information listed in the following order—authors, article title and subtitle, journal abbreviation, year, volume number in Arabic numerals, and inclusive pages. Example 1: Cohn KH, Ornstein DL, Wang F, et al. The significance of allelic deletions and aneuploidy in colorectal carcinoma: results of a 5-year follow-up study. Cancer. 1997;79:233–244.
• Book references include the following: authors, title, edition (if other than the first), volume (if more than one), city, publisher, and year. When referencing a book chapter, the order changes as follows: authors of the chapter, title of the chapter, ‘‘In:’’, editors/authors of the book, title of the book, edition (if there are more than one), volume (if there are more than one), city, publisher, year, and inclusive pages of the chapter. Example 2: Givan AL. Flow Cytometry: First Principles. 2nd ed. New York: John Wiley & Sons, Inc., 2001. Example 3: Luketich JD, Ginsberg RJ. Diagnosis and staging of lung cancer. In: Johnson BE, Johnson DH, editors. Lung Cancer. New York: Wiley-Liss, Inc., 1995:161–173.
• Electronic sources should include the type of medium (such as ‘‘computer program’’ or ‘‘CD-ROM’’), the version used, and the supplier. References to online sources should include the type of medium (such as ‘‘serial online’’ or ‘‘monograph online’’), the date of that specific reference (if applicable), the uniform resource locator (URL), and the date that the source was accessed. For web pages, please include the name of the page referenced. A source accessed online should always be referenced accordingly, even if it is also published in printed form. Example 4: Nakamura S, Yao T, Aoyagi K, Ikda M, Fujishima M, Tsuneyoshi M. Helicobacter pylori and primary gastric lymphoma: a histopathologic and immunochemical analysis of 237 patients. Cancer [serial online] 1997;79:3–11. Available from URL: http://www.onlinelibrary.wiley.com/cancer [accessed Dec 1, 1998]. Example 5: American Cancer Society. Cancer reference information. Available from URL: http://www.cancer.org/docr007/ CRI/CRI_0.asp [accessed January 26, 2006].
Authors are responsible for the accuracy and completeness of their references and for correct text citation.
• Submit single-spaced on separate pages in the word processing program used. Tables imported into the word-processing program from spreadsheet programs (eg, Microsoft Excel) should be left in table format and not converted to text. Gridlines should be retained.
• Do not embed tables as graphic files. They cannot be edited by the publisher.
• Limit tables to those that adequately and concisely present findings without redundancy.
• Cite all tables in the text. Number tables consecutively, using Arabic numerals, in the order cited in the text. The table number is followed by a brief descriptive title.
• Include table number, ‘‘continued,’’ and table subheadings on each page if a table exceeds one manuscript page.
• Define all abbreviations used in the table in footnotes to the table.
• Tables submitted as appendices or supplemental materials will be eliminated.
• Obtain written permission to reproduce previously published tabular material. Credits for the reproduced work are included as a footnote to the table and must include author(s), title, either publisher and city (and country, if other than US) or periodical name, volume, page, and year. Signed permission forms must be sent to the CA Editorial Office upon submissions.
Figures and Legends
*Authors are encouraged to submit their figure files in color. There is no charge associated with color figures.*
• Submit only publication quality figures in TIFF or EPS file format.
• The following resolutions are required to ensure print quality: 1200 dpi for line art; 300 dpi for halftones/color (RGB); 600 dpi for combination halftones/color.
• Figures should be sized to one-column width (19 picas, 3.25 inches), or two-column width (40 picas, 6.75 inches), as appropriate.
• Call out all figures in the text. Number all figures sequentially with Arabic numerals in the order cited in the text.
• Provide double-spaced legends on a separate page to include the figure number and a brief description of the figure.
• For typeface within figures, use 6-pt to 12-pt Arial or Helvetica font.
• Gray shading in figures may not reproduce well for publication and should be avoided. Do not use overall background shading in figures. Do not use gray-shaded bars in graphs—use bars with solid, open, or hatched fill. Avoid fine lines and very small type and symbols in figures. Lines should be reasonably dark and type and symbols should be easily read if the figure is reduced for publication.
• Figures with multiple parts should be labeled and referred to as (a), (b), (c), etc.
• Obtain written permission to reproduce previously published figures. Credits for the reproduced work are included in the figure legend and must include author(s), title, either publisher and city (and country, if other than US) or periodical name, volume, page, and year. Signed permission forms must be sent to the CA Editorial Office upon submission.
• Submit photographs and line art only as TIFF or EPS file formats. JPEG or GIF files are not permitted.
• Do not embed figures in word processing programs (eg, Microsoft Word).
• Mask any patient identification in photographs; otherwise, a signed permission statement is required (please see Permissions section).
• The submission of figures that do not conform to journal requirements will cause a delay in publication.
• CA reserves the right to resize and/or crop photographs to fit the journal’s format where appropriate.
Use of previously published or copyrighted material.
Information reproduced from another source must be properly cited. The corresponding author is responsible for obtaining written permission from the appropriate authors and/or copyright holders to use previously published or copyrighted material. Signed permission statements from the copyright holder for both print and online reproduction must be sent to the CA Editorial Office upon manuscript submission. Permission statements also must be obtained from at least one author when citing unpublished data, in press articles, and/or personal communications.
You can obtain permission to reproduce CA content directly from our website. Just search for the material you wish to reuse on Wiley Online Library. Click on the 'Request Permission' link.
• Follow the online instructions and select your requirements from the drop down options to gain a 'quick quote'
• Create a RightsLink® account to complete and pay for your transaction (if you do not already have one)
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Supporting information (SI) will be published in the online version of CA: A Cancer Journal for Clinicians only. SI is mentioned in the article text and published online in its original format along with the article. SI will undergo peer review with the rest of the manuscript but will not be copyedited or changed from its original format. It must be relevant but not integral to the paper. It can comprise additional tables, data sets, figures, movie files, audio clips, 3D structures, and other related nonessential multimedia files. Like the manuscript accompanying it, it should be original and not previously published. If previously published, it must be submitted with the necessary permissions. SI is hosted on Wiley Online Library (WOL) in the 'Supporting Information' section of the article and access to 'Supporting Information' is free on WOL. For more information on recommended file types, please visit http://authorservices.wiley.com/bauthor/suppinfo.asp.
Optimizing Your Article for Search Engines
Driving usage and readership is critically important to raising the visibility of your published research. One of the key factors in sustaining long-term usage is through search engine optimization (SEO). For detailed information on SEO, including helpful examples, go to http://authorservices.wiley.com/bauthor/seo.asp.
Each author should have participated sufficiently in the work to take public responsibility for the content. Authorship credit should be based on the following criteria 1) Substantial contributions to conception and design, or analysis and interpretation of data; 2) Drafting the article or revising it critically for important intellectual content; 3) Final approval of the version to be published; and 4) Agreement to be accountable for all aspects of the work. All four conditions must be met. Carefully review author status prior to submitting a manuscript. Changes to the author list (deletions and additions) may not be permitted once a manuscript is in review.
Manuscripts drafted or written, in whole or part, by individuals not listed as authors will not be considered for publication unless those contributions are clearly and accurately included in the acknowledgement section of the paper and all sources for funding those activities are disclosed in the manuscript and on the author financial disclosure forms.
Group authorship may be appropriate when a group of researchers has collaborated on a project, such as a multicenter trial, a consensus document, or an expert panel. Group authorship may be used in either of two ways:
1. Authorship may be attributed to an entire group (eg, Pediatric Oncology Group) when all members of the group meet the criteria for authorship previously outlined. In this case, the name of the group is located on the title page in the place of authors; each member of the group is listed in a footnote and his/her authorship acknowledged.
2. When specified authors assume responsibility for an entire group (eg, Jane E. Doe, John L. Smith, Mark F. Jones for the Pediatric Oncology Group), only the specified authors must meet the criteria for authorship previously outlined. All members of the group may be listed in a footnote but are not acknowledged as authors. In this case, the corresponding author must state in the cover letter that she/he has written permission from each group member to list her/his name as a member of the group.
If your paper is accepted, the corresponding author will receive an email prompting them to log into Author Services, where via the Wiley Author Licensing Service (WALS), they will be able to complete the appropriate license agreement on behalf of all authors on the paper.
PLEASE NOTE: All articles in CA are made freely available upon publication at no cost to authors. In the event you wish to pay for a Creative Commons license, you may select the OnlineOpen option as outlined below.
For authors signing the copyright transfer agreement:
If the OnlineOpen option is not selected, the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions http://authorservices.wiley.com/bauthor/faqs_copyright.asp
For authors choosing OnlineOpen:
If the OnlineOpen option is selected, the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):
Creative Commons Attribution License OAA (CC-BY)
Creative Commons Attribution Non-Commercial License OAA (CC-BY-NC)
Creative Commons Attribution Non-Commercial-NoDerivs License OAA (CC-BY-NC-ND)
To preview the terms and conditions of these open access agreements, please visit the Copyright FAQs hosted on Wiley Author Services
http://authorservices.wiley.com/bauthor/faqs_copyright.asp and visit http://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.html.
If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK), you will be given the opportunity to publish your article under a CC-BY license supporting you in compliance with The Wellcome Trust and Research Councils UK requirements. For more information on this policy, please visit: http://www.wiley.com/go/funderstatement.
Conflicts of Interest
At the time of manuscript submission, the Journal requires corresponding authors to summarize all authors' conflict of interest disclosures. This conflict of interest information is provided to editors and peer reviewers. At the time of manuscript acceptance, we ask each author, including the corresponding author, to complete his or her own International Committee of Medical Journal Editors (ICMJE) Conflict of Interest Disclosure Statement. Information about this form is available at http://www.ICMJE.org.
NIH Public Access Mandate
For those interested in the Wiley policy on the NIH Public Access Mandate, please visit our policy statement.
Authors' Professional and Ethical Responsibilities
Should possible scientific misconduct or dishonesty in research submitted for review be suspected or alleged, CA reserves the right to forward any submitted manuscript to the sponsoring or funding institution or to other appropriate authorities for investigation. CA recognizes the responsibility to ensure that the question is appropriately pursued, but does not undertake the actual investigation or make determinations of misconduct. The author will be notified if CA forwards any manuscript or materials to the sponsoring or funding institution.
Corresponding Author Responsibilities
The corresponding author is the point of contact for the Editorial Office and Publisher. He or she is responsible for:
• Completing the Conflicts of Interest Disclosure and CE disclosure forms (if the manuscript is associated with a CE quiz) on behalf of all authors and submitting these to the Editorial Office with the manuscript.
• Returning all proof corrections within 48 hours and limiting changes to corrections of typographical errors and errors in the presentation of data. It is the corresponding author's responsibility to consult with co-authors regarding the proofs.
• Page proofs. The publisher will e-mail page proofs to the corresponding author. It is up to the corresponding author to share these proofs with the other authors. The corresponding author is responsible for incorporating all the corrections made by the authors and returning the proofs to the publisher within 48 hours.
• Reviewing the CA cover. The corresponding author of the article featured on the cover of an issue of CA will receive PDF files of cover designs from the Editorial Office. He or she may share these designs with the other authors, but the corresponding author is responsible for ensuring any figure/tables/illustrations taken from the article (or supplied specifically for use on the cover) have been reproduced clearly and accurately, and for verifying the accuracy of their use for the Editorial Office.
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Form Site for submissions
• ScholarOne Manuscripts
Help with submissions
• E-mail: email@example.com
ORCID researcher iD: ORCID is a service for authors/researchers in the scholarly community that uniquely identifies your contributions to the scholarly literature. We encourage you to sign up for your free ORCID iD and add it to your ScholarOne user account.
Editorial and Peer Review
Manuscripts that adhere to submission guidelines are initially reviewed by the Editor of CA. Manuscripts qualifying for peer review are sent to at least two expert reviewers. All authors will be sent notification of the receipt of manuscripts and editorial decisions by e-mail. During the review process, designated contact authors can also check the status of the submitted manuscript via ScholarOne Manuscripts at manuscriptcentral.com/ca.
CrossCheck is a multi-publisher initiative to screen published and submitted content for originality. CA uses iThenticate software to detect instances of overlapping and similar text in submitted manuscripts. To find out more about CrossCheck visit http://www.crossref.org/crosscheck/index.html. Authors are also encouraged to review the Office of Research Integrity's definition of self-plagiarism, which can be found at ori.hhs.gov/plagiarism-13.
Proofs to Authors
Page proofs for accepted manuscripts are sent via e-mail to the corresponding author from the Publisher, John Wiley & Sons, Inc. The corresponding author must return all proof corrections within 48 hours and limit changes to corrections of typographical errors and errors in the presentation of data. It is the corresponding author's responsibility to consult with co-authors regarding the proofs. Excessive corrections must be reviewed and authorized by the Editorial Office. Correspondence regarding proofs should be directed to CA Production Editor, John Wiley & Sons, Inc., 111 River St., Hoboken, NJ 07030-5774, USA. Telephone: (201) 748-8758; Fax: (201) 748-6182/8852; E-mail: firstname.lastname@example.org.
Authors will receive instructions on how to purchase reprints inside their proof packets. Please note that regardless of the form in which they are received, reprints should not be resold, nor further disseminated in electronic form, nor deployed in part or in whole in any marking, promotional, or educational contexts without authorization from Wiley. Permission requests should be directed to email@example.com.
All authors are invited to submit potential cover art (photographs and/or illustrations preferred). See the Figures and Illustrations guidelines above for specifications. CA does not guarantee that cover art submitted will be utilized. Cover art may be submitted as "Supplementary Material Not for Review" when submitting the manuscript using ScholarOne Manuscripts. If the figure/table/illustration submitted for use on the cover does not appear in the article, a separate copyright transfer form will be required for the cover art.
Once submitted, contributions cannot be discussed with the media until one week before the publication date. Accepted articles are embargoed from reporting by all media until 12:01 A.M. (EST) on the date of online publication. Authors who discuss their work with the media prior to publication must ensure that the media representatives know the embargo policy and the embargo date. Authors arranging their own publicity on their articles are advised to notify the CA Editorial Office in advance. CA does not provide embargo dates to authors arranging their own publicity.
The American Cancer Society, in collaboration with Wiley, has launched a new website for our journal-based continuing education (CE) program. All CE activities offered in CA are FREE of charge and will award 1 AMA PRA Category 1 Credit™ or ANCC contact hours upon successful completion of the quiz. You can follow a CE link from selected CA articles to our CE website, or you can visit the CE website directly at acsjournals.com/ce. Registration is required for first-time users of the new CE website and will allow you to track your past and ongoing activities. After successfully completing each quiz, you may instantly print a certificate, and your online record of completed courses will be updated automatically. Please visit our CE website acsjournals.com/ce for our current quiz and more information about the program. Questions about the program can be sent to firstname.lastname@example.org.
Blackwell Futura Media Services is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The American Cancer Society is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.
1. International Committee of Medical Journal Editors. Uniform requirements for manuscripts submitted to biomedical journals. Available at: http://www.icmje.org. Accessed April 1, 2011.
2. American Medical Association. AMA Manual of Style: A Guide for Authors and Editors. 10th ed. New York, NY: Oxford University Press; 2007.
3. Physicians’ Desk Reference. 61st ed. Montvale, NJ: Thomson PDR; 2007.
Copyright and Permissions © 2015 American Cancer Society. All rights reserved. No part of this publication may be reproduced in any form or by any means, except as permitted under section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the publisher, or authorization through the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $10.00 per copy is paid directly to CCC, 222 Rosewood Drive, Danvers, MA 01923 USA, ISSN 0008-543X/09/$10.00.
For authorization for other kinds of copying, contact Permissions Department, John Wiley & Sons, Inc., 111 River St., Hoboken, NJ 07030-5774, USA. Telephone: (201) 748-6011; Facsimile: (201) 748-6008; E-mail: email@example.com.
Communications to the Publisher
For business inquiries, subscription information, orders, or subscriber changes of address, contact John Wiley & Sons, Inc., 111 River St., Hoboken, NJ 07030-5774, USA; or call (201) 748-6995 (toll-free 1-800-511-3989); Fax: (201) 748-6021; E-mail: firstname.lastname@example.org.