Review

The Origin of Life—Out of the Blue

  1. Prof. Dr. John D. Sutherland*

Version of Record online: 29 OCT 2015

DOI: 10.1002/anie.201506585

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 55, Issue 1, pages 104–121, January 4, 2016


Additional Information

How to Cite

Sutherland, J. D. (2016), The Origin of Life—Out of the Blue. Angew. Chem. Int. Ed., 55: 104–121. doi: 10.1002/anie.201506585

Author Information

  1. MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (UK)

*MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH (UK)

Publication History

  1. Issue online: 23 DEC 2015
  2. Version of Record online: 29 OCT 2015
  3. Manuscript Received: 16 JUL 2015

Funded by

  • Simons Foundation. Grant Number: 290362
  • Medical Research Council. Grant Number: MC UP A024 1009
  • Origin of Life Challenge

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Keywords:

  • amino acids;
  • hydrogen cyanide;
  • prebiotic chemistry;
  • ribonucleotides;
  • systems chemistry

Abstract

Either to sustain autotrophy, or as a prelude to heterotrophy, organic synthesis from an environmentally available C1 feedstock molecule is crucial to the origin of life. Recent findings augment key literature results and suggest that hydrogen cyanide—“Blausäure”—was that feedstock.

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