Extra temporal involvement in herpes simplex encephalitis

  1. M. Wasay1,
  2. S. F. Mekan1,
  3. B. Khelaeni1,
  4. Z. Saeed1,
  5. A. Hassan1,
  6. Z. Cheema2 and
  7. R. Bakshi3

Version of Record online: 9 MAY 2005

DOI: 10.1111/j.1468-1331.2005.00999.x

Issue

European Journal of Neurology

European Journal of Neurology

Volume 12, Issue 6, pages 475–479, June 2005


Additional Information

How to Cite

Wasay, M., Mekan, S. F., Khelaeni, B., Saeed, Z., Hassan, A., Cheema, Z. and Bakshi, R. (2005), Extra temporal involvement in herpes simplex encephalitis. European Journal of Neurology, 12: 475–479. doi: 10.1111/j.1468-1331.2005.00999.x

Author Information

  1. 1

    Department of Medicine and Neurology, The Aga Khan University, Karachi, Pakistan

  2. 2

    Oklahoma University Health Science center, Oklahoma City, Oklahoma, USA

  3. 3

    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, State University of New York, Buffalo, USA

*Mohammad Wasay MD, Department of Neurology, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan (tel.: 92 21 493 0051 Ext. 4665, 4681; fax: 92 21 493 4294; e-mail: mohammad.wasay@aku.edu).

Publication History

  1. Issue online: 9 MAY 2005
  2. Version of Record online: 9 MAY 2005
  3. Received 10 August 2004 Accepted 15 August 2004

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Keywords:

  • brain;
  • encephalitis;
  • herpes simplex virus;
  • MRI;
  • temporal lobe

Temporal lobe abnormalities on brain imaging have been described as strong evidence for herpes simplex encephalitis (HSE) in appropriate clinical settings. Extra temporal abnormalities are less well described in these patients. We retrospectively reviewed 20 patients of HSE and found extra temporal involvement in 11 (55%) patients. Three patients (15 %) had pure extra temporal abnormalities. Twelve patients (60%) had temporal lobe involvement, four patients (20%) had pure temporal lobe involvement and five patients (25%) had normal CT/MRI scans. Our study suggests that extra temporal involvement on brain imaging is common in HSE and in a significant minority of the patients this can even be the sole abnormality.

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