Volume 26, Issue 10 p. 1577-1583
Communication

Complex Dynamic Substrate Control: Dual-Tone Hydrogel Photoresists Allow Double-Dissociation of Topography and Modulus

Changying Xue,

Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, 4121 Eng V, Los Angeles, CA, 90095 USA

California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA, 90095 USA

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Darice Y. Wong,

Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, 4121 Eng V, Los Angeles, CA, 90095 USA

California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA, 90095 USA

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Andrea M. Kasko,

Corresponding Author

Department of Bioengineering, University of California, Los Angeles, 410 Westwood Plaza, 4121 Eng V, Los Angeles, CA, 90095 USA

California Nanosystems Institute, 570 Westwood Plaza, Los Angeles, CA, 90095 USA

E-mail: akasko@ucla.eduSearch for more papers by this author
First published: 12 December 2013
Citations: 16

Abstract

Complex substrate control is demonstrated with a dual-tone hydrogel photoresist. By exposing a photodegradable hydrogel to UV light through a photomask, both swollen and eroded micropatterns with a decreased modulus can be created on the surface under different exposure conditions. This provides an important tool for investigating the synergistic effects of spatially heterogeneous mechanical and topological cues on cell behavior.

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