Concise Report
Iridium‐Catalyzed Enantioselective C(sp3)–H Borylation of Cyclobutanes
Summary of main observation and conclusion
We herein report the first example of iridium‐catalyzed enantioselective C(sp3)–H borylation of cyclobutanes using benzoxazoline as the directing group. The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp3)–H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities. We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.
Citing Literature
Number of times cited according to CrossRef: 3
- Kai-Ge Wen, Yi-Yuan Peng, Xing-Ping Zeng, Advances in the catalytic asymmetric synthesis of quaternary carbon containing cyclobutanes, Organic Chemistry Frontiers, 10.1039/D0QO00685H, (2020).
- Yuhuan Yang, Lili Chen, Senmiao Xu, Iridium‐Catalyzed Enantioselective Unbiased Methylene C(sp3)–H Borylation of Acyclic Amides, Angewandte Chemie, 10.1002/ange.202013568, 0, 0, (2020).
- Yuhuan Yang, Lili Chen, Senmiao Xu, Iridium‐Catalyzed Enantioselective Unbiased Methylene C(sp3)–H Borylation of Acyclic Amides, Angewandte Chemie International Edition, 10.1002/anie.202013568, 0, 0, (2020).
