Article
Synthetic acth analogue semax displays nootropic‐like activity in humans
First published: September/October 1996
Cited by: 16
Abstract
Nootropic properties of ACTH4‐10 analogue, Semax, were demonstrated in experiments with human volunteers. The antihypoxic effect of Semax was shown by EEG analysis after short‐term hyperventilation. Semax induced changes in the EEG similar to those seen after administration of typical nootropic drugs. Particularly important was the long‐term (20‐24 h) beneficial action of Semax on the work efficiency of operators after intranasal administration of 0.25− 1.0 mg of the peptide (about 4.0 − 16.0 μg/kg body weight).
Citing Literature
Number of times cited: 16
- Ekaterina V. Medvedeva, Veronika G. Dmitrieva, Svetlana A. Limborska, Nikolay F. Myasoedov and Lyudmila V. Dergunova, Semax, an analog of ACTH(4−7), regulates expression of immune response genes during ischemic brain injury in rats, Molecular Genetics and Genomics, 292, 3, (635), (2017).
- Giovanni Tabbì, Antonio Magrì, Alessandro Giuffrida, Valeria Lanza, Giuseppe Pappalardo, Irina Naletova, Vincenzo Giuseppe Nicoletti, Francesco Attanasio and Enrico Rizzarelli, Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity, Journal of Inorganic Biochemistry, 10.1016/j.jinorgbio.2014.09.008, 142, (39-46), (2015).
- Ekaterina V. Medvedeva, Veronika G. Dmitrieva, Oksana V. Povarova, Svetlana A. Limborska, Veronika I. Skvortsova, Nikolay F. Myasoedov and Lyudmila V. Dergunova, Effect of Semax and its C-terminal Fragment Pro-Gly-Pro on the Expression of VEGF Family Genes and their Receptors in Experimental Focal Ischemia of the Rat Brain, Journal of Molecular Neuroscience, 49, 2, (328), (2013).
- Alfio Bertolini, Drug-induced activation of the nervous control of inflammation: A novel possibility for the treatment of hypoxic damage, European Journal of Pharmacology, 679, 1-3, (1), (2012).
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- Shih-Jen Tsai, Semax, an analogue of adrenocorticotropin (4–10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome, Medical Hypotheses, 68, 5, (1144), (2007).
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- Alexander A Fingelkurts, Andrew A Fingelkurts, Reetta Kivisaari, Eero Pekkonen, Risto J Ilmoniemi and Seppo Kähkönen, The interplay of lorazepam-induced brain oscillations: microstructural electromagnetic study, Clinical Neurophysiology, 115, 3, (674), (2004).
- Maria I. Shadrina, Oleg V. Dolotov, Igor A. Grivennikov, Petr A. Slominsky, Ludmila A. Andreeva, Ludmila S. Inozemtseva, Svetlana A. Limborska and Nikolay F. Myasoedov, Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an adrenocorticotropic hormone analog, Neuroscience Letters, 308, 2, (115), (2001).
- K. V. Sudakov, Re. Umriukhin, E. V. Koplik and K. V. Anokhin, Delta-Sleep Inducing Peptide (DSIP) and ACTH (4-10) Analogue Influence Fos-Induction in the Limbic Structures of the Rat Brain Under Emotional Stress, Stress, 4, 2, (143), (2001).
- E. V. Yakovleva, V. S. Kuzenkov, V. N. Fedorov, V. I. Skvortsova, V. B. Koshelev, E. I. Gusev and I. P. Ashmarin, In vivo efficiency of Semax in global cerebral ischemia, Bulletin of Experimental Biology and Medicine, 128, 2, (806), (1999).
