Conducted conversationally with one respondent at a time, the semi‐structured interview (SSI) employs a blend of closed‐ and open‐ended questions, often accompanied by follow‐up why or how questions. About one hour is considered a reasonable maximum length for SSIs in order to minimize fatigue for both interviewer and respondent. This chapter begins with a discussion on the disadvantages and advantages of SSIs. Despite the disadvantages and costs of SSIs, they offer some extraordinary benefits as well. Semi‐structured interviews are superbly suited for a number of valuable tasks, particularly when more than a few of the open‐ended questions require follow‐up queries. The chapter presents some recommendations that can be considered when constructing an SSI guide. All in all, effectively conducted semi‐structured interviews, even though labor intensive, should be worth the effort in terms of the insights and information gained.