Translational potential of human brain organoids
[Correction added on 14 February 2018 after first online publication: Missing data was added in the Funding information nd Figure 2 was replaced with the correct image.]
Abstract
The recent technology of 3D cultures of cellular aggregates derived from human stem cells have led to the emergence of tissue‐like structures of various organs including the brain. Brain organoids bear molecular and structural resemblance with developing human brains, and have been demonstrated to recapitulate several physiological and pathological functions of the brain. Here we provide an overview of the development of brain organoids for the clinical community, focusing on the current status of the field with an critical evaluation of its translational value.
