Communication

Break‐up of Two‐Dimensional MnO₂ Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

These authors contributed equally to this work.

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Delai Ye

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

These authors contributed equally to this work.

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Meiying Wu

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Hangrong Chen

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Linlin Zhang

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Jianlin Shi

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

E‐mail: l.wang@uq.edu.au, jlshi@mail.sic.ac.cn Search for more papers by this author

Lianzhou Wang

Corresponding Author

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

E‐mail: l.wang@uq.edu.au, jlshi@mail.sic.ac.cn Search for more papers by this author

Yu Chen

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

These authors contributed equally to this work.

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Delai Ye

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

These authors contributed equally to this work.

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Meiying Wu

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Hangrong Chen

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Linlin Zhang

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

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Jianlin Shi

Corresponding Author

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China

E‐mail: l.wang@uq.edu.au, jlshi@mail.sic.ac.cn Search for more papers by this author

Lianzhou Wang

Corresponding Author

Nanomaterials Center, School of Chemical Engineering and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, 4072 Australia

E‐mail: l.wang@uq.edu.au, jlshi@mail.sic.ac.cn Search for more papers by this author

First published: 22 August 2014

https://doi.org/10.1002/adma.201402572

Citations: 227

Abstract

Chemically exfoliated two‐dimensional MnO₂ nanosheets are successfully modified with amino‐polyethylene glycol as a theranostic platform for ultrasensitive stimuli‐responsive theranostics of cancer. The highly dispersed MnO₂ nanosheets exhibit a unique break‐up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T₁‐weighted magnetic resonance imaging. Such a pH‐triggered breaking‐up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH‐responsive drug release and circumvent the multidrug resistance of cancer cells.