Volume 30, Issue 20
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Bio‐Nanostructures: Protein Bricks: 2D and 3D Bio‐Nanostructures with Shape and Function on Demand (Adv. Mater. 20/2018)

Jianjuan Jiang

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

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Shaoqing Zhang

Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, 78712 USA

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Zhigang Qian

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240 China

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Nan Qin

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

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Wenwen Song

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240 China

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Long Sun

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

School of Graduate Study, University of Chinese Academy of Sciences, Beijing, 100049 China

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Zhitao Zhou

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

School of Graduate Study, University of Chinese Academy of Sciences, Beijing, 100049 China

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Zhifeng Shi

Department of Neurosurgery, Huashan Hospital of Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040 China

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Liang Chen

Department of Neurosurgery, Huashan Hospital of Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040 China

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Xinxin Li

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

School of Physical Science and Technology, Shanghai Tech University, Shanghai, 200031 China

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Ying Mao

Department of Neurosurgery, Huashan Hospital of Fudan University, Wulumuqi Zhong Road 12, Shanghai, 200040 China

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David L. Kaplan

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155 USA

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Stephanie N. Gilbert Corder

Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794 USA

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Xinzhong Chen

Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794 USA

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Mengkun Liu

Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794 USA

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Fiorenzo G. Omenetto

Department of Biomedical Engineering, Tufts University, Medford, MA, 02155 USA

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Xiaoxia Xia

State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240 China

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Tiger H. Tao

State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050 China

Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, 78712 USA

School of Graduate Study, University of Chinese Academy of Sciences, Beijing, 100049 China

School of Physical Science and Technology, Shanghai Tech University, Shanghai, 200031 China

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First published: 14 May 2018

Abstract

A class of well‐defined, complex protein‐based 2D and 3D nanostructures with shape and function on demand is manufactured and assembled via “Protein Bricks” by precisely patterning on genetically engineered spider silk using ion and electron beams, as reported by Xiaoxia Xia, Tiger H. Tao, and co‐workers in article number 1705919. This approach provides a facile method for excellent biocompatibility, ease of functionalization, heterogeneous nanostructuring, and controllable 3D assembly, shedding light on a wide range of applications such as biosensing for structure enhanced fluorescence and biomimetic microenvironments for controlling cell fate.

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