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Brief Communication

High‐intensity focused ultrasound for noninvasive functional neurosurgery*

Ernst Martin MD

Corresponding Author

E-mail address:ernst.martin@kispi.uzh.ch

MR‐Center, University Children's Hospital Zurich, Zurich, Switzerland

All authors contributed equally to this work.
MR‐Center, University Children's Hospital Zurich, Steinwiesstrasse 75, CH‐8032 Zurich, Switzerland
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Daniel Jeanmonod MD

Department of Functional Neurosurgery, University Hospital Zurich, Zurich, Switzerland

All authors contributed equally to this work.Search for more papers by this author
Anne Morel PhD

Department of Functional Neurosurgery, University Hospital Zurich, Zurich, Switzerland

All authors contributed equally to this work.Search for more papers by this author
Eyal Zadicario MSc

InSightec, Ltd., Tirat Carmel, Israel

All authors contributed equally to this work.Search for more papers by this author
Beat Werner MSc

MR‐Center, University Children's Hospital Zurich, Zurich, Switzerland

All authors contributed equally to this work.Search for more papers by this author
First published: 13 July 2009
Cited by: 36
*

Potential conflict of interest: Nothing to report.

Abstract

Transcranial magnetic resonance (MR)‐guided high‐intensity focused ultrasound (tcMRgHIFU) implies a novel, noninvasive treatment strategy for various brain diseases. Nine patients with chronic neuropathic pain were treated with selective medial thalamotomies. Precisely located thermal ablations of 4mm in diameter were produced at peak temperatures of 51°C to 60°C under continuous visual MR guidance and MR thermometry. The resulting lesions are clearly visible on follow‐up MR imaging. All treatments were well tolerated, without side effects or neurological deficits. This is the first report on successful clinical application of tcMRgHIFU in functional brain disorders, portraying it as safe and reliable for noninvasive neurosurgical interventions. Ann Neurol 2009;66:858–861

Number of times cited: 36

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