Tip‐Enhanced Raman Spectroscopy of Single RNA Strands: Towards a Novel Direct‐Sequencing Method
Abstract
Walking the strand: Tip‐enhanced Raman scattering (TERS) with precision probe positioning has been used to obtain high‐quality Raman spectra of the nucleobases in a single RNA strand (see picture: foreground Raman spectrum, background atomic‐force microscope tip positioned over the RNA strand). This procedure represents the first step towards direct and label‐free single‐biomolecule sequencing.
Number of times cited: 190
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