Selenenylsulfide‐Linked Homogeneous Glycopeptides and Glycoproteins: Synthesis of Human “Hepatic Se Metabolite A”†
We thank the European Commission (Marie Curie Intra‐European Fellowship for O.B.), FCT, Portugal (G.J.L.B.), and Xunta de Galicia, Spain (M.F.G.) for financial support. B.G.D. is a recipient of a Royal Society Wolfson Merit Award and is supported by an EPSRC LSI Platform grant. We thank Dr. J. S. O. McCullagh and M. K. Patel for technical assistance.
Abstract
Introducing selenium: The synthesis and full characterization of human hepatic Se metabolite A has been accomplished by using a robust, efficient, and Cys‐specific selenenylation protocol (see scheme; NaPi=sodium phosphate). The selenenylsulfide linkage is sufficiently stable to allow quantification of Se‐containing glycoconjugates in biological fluids by using atomic detection methods.
