Communication

Regulation of Redox Potential of a Pterin Derivative Bound to a Ruthenium(II) Complex by Intermolecular Hydrogen Bonding with Nucleobases^†

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Dr. Soushi Miyazaki

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Dr. Kei Ohkubo

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Prof. Dr. Shunichi Fukuzumi

Corresponding Author

fukuzumi@chem.eng.osaka‐u.ac.jp

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Department of Bioinspired Science, Ewha Womans University, Seoul 120‐750 (Korea)

Shunichi Fukuzumi, Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Takahiko Kojima, Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

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Prof. Dr. Takahiko Kojima

Corresponding Author

kojima@chem.tsukuba.ac.jp

Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

Shunichi Fukuzumi, Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Takahiko Kojima, Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

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Yuji Inui

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Dr. Soushi Miyazaki

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Dr. Kei Ohkubo

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

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Prof. Dr. Shunichi Fukuzumi

Corresponding Author

fukuzumi@chem.eng.osaka‐u.ac.jp

Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Department of Bioinspired Science, Ewha Womans University, Seoul 120‐750 (Korea)

Shunichi Fukuzumi, Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Takahiko Kojima, Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

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Prof. Dr. Takahiko Kojima

Corresponding Author

kojima@chem.tsukuba.ac.jp

Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

Shunichi Fukuzumi, Department of Material and Life Science, Graduate School of Engineering, Osaka University, and ALCA (JST), 2‐1 Yamada‐oka, Suita, Osaka 565‐0871 (Japan)

Takahiko Kojima, Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1‐1‐1 Tennoudai, Tsukuba, Ibaraki 305‐8571 (Japan)

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First published: 30 March 2012

https://doi.org/10.1002/anie.201108827

Citations: 5

^†

This work was supported by Grants‐in‐Aid (Nos. 23750014, 20108010, 21350035, and 20108001), a Global COE program, “The Global Education and Research Center for Bio‐Environmental Chemistry” from the Japan Society of Promotion of Science (JSPS), the Ministry of Education, Science, and Technology of Japan, and by KOSEF/MEST through WCU project (R31‐2008‐000‐10010‐0) of Korea.

Abstract

Potential control: A Ru^II‐bound pterin forms a stable hydrogen‐bonding adduct with a guanine derivative through three‐point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.