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Cysteine‐Selective Reactions for Antibody Conjugation†
†
P.M.S.D.C. and P.M.P.G. thank FCT (PTDC/QUI‐QUI/118315/2010, Pest‐OE/SAU/UI4013/2011, SFRH/BD/72376/2010) for financial support. G.J.L.B. is a Royal Society University Research Fellow and an FCT Investigator.
Abstract
Moving tracks from maleimide: New site‐selective protein modification reactions at cysteine have been developed. Unlike conventional maleimide conjugation, which results in a labile thioether succinimide, the new bioconjugation reactions result in stable conjugates and provide opportunities to develop a new generation of homogeneous, stable, and therapeutically useful conjugates.
