Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy
Abstract
The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy (X‐PDT) with negligible side effects. The aggregates of glutathione‐protected gold clusters (GCs) assembled through a cationic polymer enhanced the X‐ray‐excited luminescence by 5.2‐fold. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE‐Au effectively triggered the generation of reactive oxygen species with an order‐of‐magnitude reduction in the X‐ray dose, enabling highly effective cancer treatment.
Citing Literature
Number of times cited according to CrossRef: 11
- Zhenhua Hu, Wen-Hua Chen, Jie Tian, Zhen Cheng, NIRF Nanoprobes for Cancer Molecular Imaging: Approaching Clinic, Trends in Molecular Medicine, 10.1016/j.molmed.2020.02.003, (2020).
- Yufu Ren, Justin G. Rosch, Madeleine R. Landry, Hayden Winter, Syamantak Khan, Guillem Pratx, Conroy Sun, Tb-Doped core–shell–shell nanophosphors for enhanced X-ray induced luminescence and sensitization of radiodynamic therapy, Biomaterials Science, 10.1039/D0BM00897D, (2020).
- Zhongzheng Yu, Wen Kiat Chan, Yan Zhang, Timothy Thatt Yang Tan, Near-infrared-II activated inorganic photothermal nanomedicines, Biomaterials, 10.1016/j.biomaterials.2020.120459, (120459), (2020).
- Vladimir Mulens-Arias, Alice Balfourier, Alba Nicolás-Boluda, Florent Carn, Florence Gazeau, Endocytosis-driven gold nanoparticle fractal rearrangement in cells and its influence on photothermal conversion, Nanoscale, 10.1039/D0NR05886F, (2020).
- Siqi Xie, Qi Liu, Fawei Zhu, Miao Chen, Lumin Wang, Yu Xiong, Yuqiu Zhu, Yu Zheng, Xiaoqing Chen, AIE-active metal–organic frameworks: facile preparation, tunable light emission, ultrasensitive sensing of copper( ii ) and visual fluorescence detection of glucose , Journal of Materials Chemistry C, 10.1039/D0TC00106F, (2020).
- Man-Man Xu, Tong-Tong Jia, Bingjie Li, Wang Ma, Xiaoyuan Chen, Xueli Zhao, Shuang-Quan Zang, Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery, Chemical Communications, 10.1039/D0CC03498C, (2020).
- Youkun Zheng, Jianbo Wu, Hui Jiang, Xuemei Wang, Gold nanoclusters for theranostic applications, Coordination Chemistry Reviews, 10.1016/j.ccr.2020.213689, (213689), (2020).
- Li Luo, Wenjing Sun, Yushuo Feng, Ruixue Qin, Jinghui Zhang, Dandan Ding, Tianhang Shi, Xiangmei Liu, Xiaoyuan Chen, Hongmin Chen, Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X-Ray-Induced Photodynamic Therapy of Tumors, ACS Applied Materials & Interfaces, 10.1021/acsami.0c01189, (2020).
- Zaira Gadzhimagomedova, Peter Zolotukhin, Oleg Kit, Daria Kirsanova, Alexander Soldatov, Nanocomposites for X-Ray Photodynamic Therapy, International Journal of Molecular Sciences, 10.3390/ijms21114004, 21, 11, (4004), (2020).
- Yao Yang, Weiwei Zeng, Ping Huang, Xiaowei Zeng, Lin Mei, Smart materials for drug delivery and cancer therapy, View, 10.1002/VIW.20200042, 0, 0, (undefined).
- Hanyu Liang, Zhongzhu Hong, Shihua Li, Xiaorong Song, Da Zhang, Qiushui Chen, Juan Li, Huanghao Yang, An Activatable X‐Ray Scintillating Luminescent Nanoprobe for Early Diagnosis and Progression Monitoring of Thrombosis in Live Rat, Advanced Functional Materials, 10.1002/adfm.202006353, 0, 0, (undefined).
