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Research Article
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Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

Kevin P. Baker

Corresponding Author

E-mail address:kevin_baker@hgsi.com

Human Genome Sciences, Inc., Rockville, Maryland

Department of Antibody Discovery and Development, Human Genome Sciences, Inc., 9410 Key West Avenue, Rockville, MD 20850
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Bryan M. Edwards

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Sarah H. Main

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Gil H. Choi

Human Genome Sciences, Inc., Rockville, Maryland

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Ruth E. Wager

Human Genome Sciences, Inc., Rockville, Maryland

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Wendy G. Halpern

Human Genome Sciences, Inc., Rockville, Maryland

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Patrick B. Lappin

Charles River Laboratories, Sierra Biomedical Division, Sparks, Nevada

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Todd Riccobene

Human Genome Sciences, Inc., Rockville, Maryland

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Donara Abramian

Human Genome Sciences, Inc., Rockville, Maryland

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Les Sekut

Human Genome Sciences, Inc., Rockville, Maryland

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Bonnie Sturm

Human Genome Sciences, Inc., Rockville, Maryland

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Carol Poortman

Human Genome Sciences, Inc., Rockville, Maryland

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Ralph R. Minter

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Claire L. Dobson

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Elizabeth Williams

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Sara Carmen

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Rodger Smith

Human Genome Sciences, Inc., Rockville, Maryland

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Viktor Roschke

Human Genome Sciences, Inc., Rockville, Maryland

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David M. Hilbert

Human Genome Sciences, Inc., Rockville, Maryland

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Tristan J. Vaughan

Cambridge Antibody Technology, Granta Park, Cambridge, UK

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Vivian R. Albert

Human Genome Sciences, Inc., Rockville, Maryland

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First published: 04 November 2003
Cited by: 239

Abstract

Objective

To identify and characterize a fully human antibody directed against B lymphocyte stimulator (BLyS), a tumor necrosis factor–related cytokine that plays a critical role in the regulation of B cell maturation and development. Elevated levels of BLyS have been implicated in the pathogenesis of autoimmune diseases.

Methods

A human phage display library was screened for antibodies against human BLyS. A human monoclonal antibody, LymphoStat‐B, specific for human BLyS was obtained from the library screening and subsequent affinity optimization mutagenesis. The antibody was tested for inhibition of human BLyS in vitro and in an in vivo murine model. Additionally, the consequences of BLyS inhibition were tested in vivo by administration of LymphoStat‐B to cynomolgus monkeys.

Results

LymphoStat‐B bound with high affinity to human BLyS and inhibited the binding of BLyS to its 3 receptors, TACI, BCMA, and BLyS receptor 3/BAFF‐R. LymphoStat‐B potently inhibited BLyS‐induced proliferation of B cells in vitro, and administration of LymphoStat‐B to mice prevented human BLyS‐induced increases in splenic B cell numbers and IgA titers. In cynomolgus monkeys, administration of LymphoStat‐B resulted in decreased B cell representation in both spleen and mesenteric lymph nodes.

Conclusion

A fully human monoclonal antibody has been isolated that binds to BLyS with high affinity and neutralizes human BLyS bioactivity in vitro and in vivo. Administration of this antibody to cynomolgus monkeys resulted in B cell depletion in spleen and lymph node. This antibody may prove therapeutically useful in the treatment of autoimmune diseases in humans.

Number of times cited: 239

  • , Long‐Term Safety and Efficacy of Belimumab in Patients With Systemic Lupus Erythematosus, Arthritis & Rheumatology, 70, 6, (868-877), (2018).
  • , Belimumab: A Review in Systemic Lupus Erythematosus, Drugs, (2018).
  • , Efficacy and Safety of Subcutaneous Belimumab in Anti–Double‐Stranded DNA–Positive, Hypocomplementemic Patients With Systemic Lupus Erythematosus, Arthritis & Rheumatology, 70, 8, (1256-1264), (2018).
  • , Belimumab for the Treatment of Early Diffuse Systemic Sclerosis, Arthritis & Rheumatology, 70, 2, (308-316), (2017).
  • , Update on systemic vasculitides, Journal of Clinical Pathology, 10.1136/jclinpath-2016-203875, 70, 6, (476-482), (2017).
  • , Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases, International Reviews of Immunology, 10.1080/08830185.2016.1276903, 36, 1, (3-19), (2017).
  • , Immunotherapy, Practical Immunodermatology, 10.1007/978-94-024-0902-4_15, (367-381), (2016).
  • , A randomized, open-label study to investigate the effect of belimumab on pneumococcal vaccination in patients with active, autoantibody-positive systemic lupus erythematosus, Lupus, 10.1177/0961203317703495, 26, 14, (1483-1490), (2017).
  • , Immunophenotyping in Drug Development, Reference Module in Biomedical Sciences, 10.1016/B978-0-12-801238-3.64236-8, (2017).
  • , Efficacy and Safety of Subcutaneous Belimumab in Systemic Lupus Erythematosus: A Fifty‐Two–Week Randomized, Double‐Blind, Placebo‐Controlled Study, Arthritis & Rheumatology, 69, 5, (1016-1027), (2017).
  • , The Future of B-cell Activating Factor Antagonists in the Treatment of Systemic Lupus Erythematosus, Journal of Rheumatic Diseases, 10.4078/jrd.2017.24.2.65, 24, 2, (65), (2017).
  • , Belimumab in systemic lupus erythematosus (SLE): evidence-to-date and clinical usefulness, Therapeutic Advances in Musculoskeletal Disease, 10.1177/1759720X17690474, 9, 3, (75-85), (2017).
  • , Inhibition of B cell activating factor (BAFF) in the management of systemic lupus erythematosus (SLE), Expert Review of Clinical Immunology, 10.1080/1744666X.2017.1291343, 13, 6, (623-633), (2017).
  • , Subcutaneous and intravenous belimumab in the treatment of systemic lupus erythematosus: a review of data on subcutaneous and intravenous administration, Expert Review of Clinical Immunology, 10.1080/1744666X.2017.1371592, 13, 10, (925-938), (2017).
  • , Belimumab use, clinical outcomes and glucocorticoid reduction in patients with systemic lupus erythematosus receiving belimumab in clinical practice settings: results from the OBSErve Canada Study, Rheumatology International, 10.1007/s00296-017-3682-9, 37, 6, (865-873), (2017).
  • , Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus, Autoimmunity Reviews, 10.1016/j.autrev.2017.02.005, 16, 4, (343-351), (2017).
  • , Binding of B‐cell maturation antigen to B‐cell activating factor induces survival of multiple myeloma cells by activating Akt and JNK signaling pathways, Cell Biochemistry and Function, 34, 2, (104-110), (2016).
  • , Unexpected Potency Differences between B-Cell-Activating Factor (BAFF) Antagonist Antibodies against Various Forms of BAFF: Trimer, 60-Mer, and Membrane-Bound, Journal of Pharmacology and Experimental Therapeutics, 10.1124/jpet.116.236075, 359, 1, (37-44), (2016).
  • , Update on clinical trials in systemic lupus erythematosus, Current Opinion in Rheumatology, 10.1097/BOR.0000000000000311, 28, 5, (477-487), (2016).
  • , Current and future immunotherapy targets in autoimmune neurology, Autoimmune Neurology, 10.1016/B978-0-444-63432-0.00027-X, (511-536), (2016).
  • , First Real-World Insights into Belimumab Use and Outcomes in Routine Clinical Care of Systemic Lupus Erythematosus in Germany: Results from the OBSErve Germany Study, Rheumatology and Therapy, 10.1007/s40744-016-0047-x, 3, 2, (271-290), (2016).
  • , Monoclonal Antibodies as Therapeutic Agents, Immunopharmacology, 10.1007/978-3-319-30273-7_5, (157-196), (2016).
  • , Targeting B cells in treatment of autoimmunity, Current Opinion in Immunology, 10.1016/j.coi.2016.09.003, 43, (39-45), (2016).
  • , Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects, Clinical Pharmacology in Drug Development, 5, 3, (208-215), (2015).
  • , Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab, Lupus, 10.1177/0961203315604909, 25, 4, (346-354), (2015).
  • , Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people, The Veterinary Journal, 10.1016/j.tvjl.2015.10.022, 207, (13-19), (2016).
  • , Generation and characterization of human B lymphocyte stimulator blocking monoclonal antibody, Molecular Immunology, 10.1016/j.molimm.2016.08.002, 77, (141-147), (2016).
  • , The diagnosis and clinical management of the neuropsychiatric manifestations of lupus, Journal of Autoimmunity, 10.1016/j.jaut.2016.06.013, 74, (41-72), (2016).
  • , Phage display-derived human antibodies in clinical development and therapy, mAbs, 10.1080/19420862.2016.1212149, 8, 7, (1177-1194), (2016).
  • , Role of the cytokine BAFF in autoimmune diseases: Physiopathology and therapeutic targets, Revista Colombiana de Reumatología (English Edition), 10.1016/j.rcreue.2016.11.003, 23, 3, (177-194), (2016).
  • , Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus, Lupus, 10.1177/0961203316655215, 25, 14, (1587-1596), (2016).
  • , Fully human anti-BAFF inhibitory monoclonal antibody tabalumab does not adversely affect T-dependent antibody responses in cynomolgus monkey ( Macaca fasicularis ): A summary of three pre-clinical immunotoxicology evaluations , Journal of Immunotoxicology, 10.3109/1547691X.2014.994793, 13, 1, (7-19), (2015).
  • , B cell-independent contribution of BAFF to murine autoimmune disease, Clinical Immunology, 10.1016/j.clim.2016.07.009, 172, (111-116), (2016).
  • , Papel de la citocina BAFF en las enfermedades autoinmunes: rol fisiopatológico y estrategias terapéuticas, Revista Colombiana de Reumatología, 10.1016/j.rcreu.2016.06.003, 23, 3, (177-194), (2016).
  • , Blisibimod for treatment of systemic lupus erythematosus: with trials you become wiser, Expert Opinion on Biological Therapy, 10.1517/14712598.2016.1169270, 16, 5, (723-733), (2016).
  • , New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression, Journal of Clinical Immunology, 10.1007/s10875-016-0263-8, 36, S1, (25-33), (2016).
  • , Pharmacology, Textbook of Pediatric Rheumatology, 10.1016/B978-0-323-24145-8.00013-2, (161-175.e6), (2016).
  • , VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry, Molecular Immunology, 10.1016/j.molimm.2016.05.009, 75, (28-37), (2016).
  • , Mechanism of Action for Therapeutic Antibodies, Biosimilars of Monoclonal Antibodies, (85-111), (2016).
  • , Cumulative Corticosteroid Dose Over Fifty‐Two Weeks in Patients With Systemic Lupus Erythematosus: Pooled Analyses From the Phase III Belimumab Trials, Arthritis & Rheumatology, 68, 9, (2184-2192), (2016).
  • , Advances in phage display technology for drug discovery, Expert Opinion on Drug Discovery, 10.1517/17460441.2015.1037738, 10, 6, (651-669), (2015).
  • , Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials, Arthritis Research & Therapy, 10.1186/s13075-015-0741-z, 17, 1, (2015).
  • , Lessons Learned From the Clinical Trials of Novel Biologics and Small Molecules in Lupus Nephritis, Seminars in Nephrology, 10.1016/j.semnephrol.2015.08.012, 35, 5, (509-520), (2015).
  • , Naive Antibody Libraries from Natural Repertoires, Phage Display In Biotechnology and Drug Discovery, Second Edition, 10.1201/b18196-18, (455-494), (2015).
  • , B-cell survival factors in autoimmune rheumatic disorders, Therapeutic Advances in Musculoskeletal Disease, 10.1177/1759720X15586782, 7, 4, (122-151), (2015).
  • , Generation and analysis of the improved human HAL9/10 antibody phage display libraries, BMC Biotechnology, 10.1186/s12896-015-0125-0, 15, 1, (10), (2015).
  • , A Retrospective Administrative Claims Database Evaluation of the Utilization of Belimumab in US Managed Care Settings, Clinical Therapeutics, 10.1016/j.clinthera.2015.10.008, 37, 12, (2852-2863), (2015).
  • , Belimumab in systemic lupus erythematosus: a perspective review, Therapeutic Advances in Musculoskeletal Disease, 10.1177/1759720X15588514, 7, 4, (115-121), (2015).
  • , BAFF blockade prevents anti-drug antibody formation in a mouse model of Pompe disease, Clinical Immunology, 10.1016/j.clim.2015.03.022, 158, 2, (140-147), (2015).
  • , The role of BAFF in the progression of rheumatoid arthritis, Cytokine, 10.1016/j.cyto.2015.07.014, 76, 2, (537-544), (2015).
  • , 'That Obscure Object of Desire': in systemic lupus erythematosus B-cell activating factor/B-lymphocyte stimulator is targeted both by the immune system and by physicians, Nephrology Dialysis Transplantation, 10.1093/ndt/gfu213, 30, 3, (394-400), (2014).
  • , Evaluation of B lymphocyte stimulator and a proliferation inducing ligand as candidate biomarkers in lupus nephritis based on clinical and histopathological outcome following induction therapy, Lupus Science & Medicine, 10.1136/lupus-2014-000061, 2, 1, (e000061-e000061), (2015).
  • , The pharmacokinetics and safety profiles of belimumab after single subcutaneous and intravenous doses in healthy Japanese volunteers, Journal of Clinical Pharmacy and Therapeutics, 39, 1, (97-101), (2013).
  • , Therapeutic targeting of the BAFF/APRIL axis in systemic lupus erythematosus, Expert Opinion on Therapeutic Targets, 10.1517/14728222.2014.888415, 18, 4, (473-489), (2014).
  • , Post-marketing Experiences with Belimumab in the Treatment of SLE Patients, Rheumatic Disease Clinics of North America, 10.1016/j.rdc.2014.04.007, 40, 3, (507-517), (2014).
  • , Behçet’s syndrome pathophysiology and potential therapeutic targets, Internal and Emergency Medicine, 10.1007/s11739-013-1036-5, 9, 3, (257-265), (2014).
  • , Lupus clinical development: will belimumab's approval catalyse a new paradigm for SLE drug development?, Expert Opinion on Biological Therapy, 10.1517/14712598.2014.884065, 14, 4, (491-501), (2014).
  • , Update on B-cell targeted therapies for systemic lupus erythematosus, Expert Opinion on Biological Therapy, 10.1517/14712598.2014.895810, 14, 6, (773-788), (2014).
  • , Recent developments in the treatment of patients with systemic lupus erythematosus: focusing on biologic therapies, Expert Opinion on Biological Therapy, 10.1517/14712598.2014.871256, 14, 3, (311-326), (2014).
  • , Drugs derived from phage display, mAbs, 10.4161/mabs.27240, 6, 1, (73-85), (2013).
  • , Serum B-cell Activating Factor in Myecloperoxiase-antineutrophil Cytoplasmic Antibodies-associated Vasculitis, The American Journal of the Medical Sciences, 10.1097/MAJ.0b013e3182a55ab6, 348, 1, (25-29), (2014).
  • , Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials, Annals of the Rheumatic Diseases, 10.1136/annrheumdis-2012-202865, 73, 5, (838-844), (2013).
  • , Biologics in SLE: Towards new approaches, Best Practice & Research Clinical Rheumatology, 10.1016/j.berh.2013.07.006, 27, 3, (341-349), (2013).
  • , Belimumab for systemic lupus erythematosus: a practice-based view, Lupus, 10.1177/0961203313476154, 22, 4, (372-380), (2013).
  • , Systemic Lupus Erythematosus, Dental Clinics of North America, 10.1016/j.cden.2013.06.003, 57, 4, (631-655), (2013).
  • , Ectopic germinal centers, BAFF and anti-B-cell therapy in myasthenia gravis, Autoimmunity Reviews, 10.1016/j.autrev.2013.03.011, 12, 9, (885-893), (2013).
  • , Consenso de la Sociedad Española de Reumatología sobre el uso de terapias biológicas en el lupus eritematoso sistémico, Reumatología Clínica, 10.1016/j.reuma.2013.04.001, 9, 5, (281-296), (2013).
  • , Population Pharmacokinetics of Belimumab Following Intravenous Administration in Patients With Systemic Lupus Erythematosus, The Journal of Clinical Pharmacology, 53, 7, (711-720), (2013).
  • , Protein engineering and preclinical development of a GM‐CSF receptor antibody for the treatment of rheumatoid arthritis, British Journal of Pharmacology, 168, 1, (200-211), (2012).
  • , Belimumab Therapy in Systemic Lupus Erythematosus, BioDrugs, 10.1007/s40259-013-0031-8, 27, 3, (225-235), (2013).
  • , Monoclonal antibody treatments for rheumatoid arthritis, Expert Opinion on Biological Therapy, 10.1517/14712598.2013.811230, 13, 9, (1257-1272), (2013).
  • , Immune Thrombocytopenia and B-Cell-Activating Factor/A Proliferation-Inducing Ligand, Seminars in Hematology, 10.1053/j.seminhematol.2013.03.021, 50, (S89-S99), (2013).
  • , Systemic lupus erythematosus: an update on current pharmacotherapy and future directions, Expert Opinion on Biological Therapy, 10.1517/14712598.2013.764411, 13, 5, (723-737), (2013).
  • , Allogenic Mesenchymal Stem Cell Transplantation Ameliorates Nephritis in Lupus Mice via Inhibition of B-Cell Activation, Cell Transplantation, 10.3727/096368912X658692, 22, 12, (2279-2290), (2013).
  • , SER Consensus Statement on the Use of Biologic Therapy for Systemic Lupus Erythematosus, Reumatología Clínica (English Edition), 10.1016/j.reumae.2013.07.001, 9, 5, (281-296), (2013).
  • , Novel Therapies for SLE, Dubois' Lupus Erythematosus and Related Syndromes, 10.1016/B978-1-4377-1893-5.00053-4, (640-647), (2013).
  • , Belimumab – an anti-BLyS human monoclonal antibody for rheumatoid arthritis, Expert Opinion on Biological Therapy, 10.1517/14712598.2012.758248, 13, 2, (315-322), (2012).
  • , Biological Therapies for Rheumatoid Arthritis: Progress to Date, BioDrugs, 10.1007/s40259-013-0021-x, 27, 4, (329-345), (2013).
  • , Empfehlungen zum Einsatz von Belimumab beim systemischen Lupus erythematodesRecommendation for use of belimumab for systemic lupus erythematosus, Zeitschrift für Rheumatologie, 10.1007/s00393-013-1212-z, 72, 5, (462-467), (2013).
  • , Receptor‐Fc and Ligand Traps as High‐Affinity Biological Blockers: Development and Clinical Applications, Fusion Protein Technologies for Biopharmaceuticals, (143-162), (2013).
  • , BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus, IUBMB Life, 64, 7, (595-602), (2012).
  • , B Cell‐Activating Factor Enhances Interleukin‐6 and Interleukin‐10 Production by ODN‐Activated Human B Cells, Scandinavian Journal of Immunology, 76, 4, (371-377), (2012).
  • , Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus, Arthritis & Rheumatism, 64, 7, (2328-2337), (2012).
  • , Belimumab: Review of Use in Systemic Lupus Erythematosus, Clinical Therapeutics, 10.1016/j.clinthera.2012.02.028, 34, 5, (1006-1022), (2012).
  • , Biologic Differences Between Various Inhibitors of the BLyS/BAFF Pathway: Should We Expect Differences Between Belimumab and Other Inhibitors in Development?, Current Rheumatology Reports, 10.1007/s11926-012-0254-6, 14, 4, (303-309), (2012).
  • , Belimumab: A Guide to Its Use in Systemic Lupus Erythematosus, BioDrugs, 10.2165/11209060-000000000-00000, 26, 3, (195-199), (2012).
  • , B cell abnormality in systemic lupus erythematosus, Japanese Journal of Clinical Immunology, 10.2177/jsci.35.495, 35, 6, (495-502), (2012).
  • , To Market, To Market—2011, Annual Reports in Medicinal Chemistry Volume 47, 10.1016/B978-0-12-396492-2.00031-X, (499-569), (2012).
  • , Cellular Targeting in Autoimmunity, Current Allergy and Asthma Reports, 10.1007/s11882-012-0307-y, 12, 6, (495-510), (2012).
  • , Generation of Gene-Engineered Chimeric DNA Molecules for Specific Therapy of Autoimmune Diseases, Human Gene Therapy Methods, 10.1089/hgtb.2012.051, 23, 6, (357-365), (2012).
  • , Belimumab in systemic lupus erythematosus: an update for clinicians, Therapeutic Advances in Chronic Disease, 10.1177/2040622311424806, 3, 1, (11-23), (2011).
  • , Belimumab in SLE, Immunotherapeutic Agents for SLE, 10.2217/ebo.11.207, (42-54), (2012).
  • , Tailored amino acid diversity for the evolution of antibody affinity, mAbs, 10.4161/mabs.21728, 4, 6, (664-672), (2014).
  • , B-cell activating factor targeted therapy and lupus, Arthritis Research & Therapy, 10.1186/ar3920, 14, Suppl 4, (S2), (2012).
  • , B Cell Targeted Therapy in Rheumatic Disease, Journal of Rheumatic Diseases, 10.4078/jrd.2012.19.2.67, 19, 2, (67), (2012).
  • , BAFF and innate immunity: new therapeutic targets for systemic lupus erythematosus, Immunology & Cell Biology, 90, 3, (293-303), (2012).
  • , Long‐term safety profile of belimumab plus standard therapy in patients with systemic lupus erythematosus, Arthritis & Rheumatism, 64, 10, (3364-3373), (2012).
  • , The role of B cell–activating factor in autoimmune myasthenia gravis, Annals of the New York Academy of Sciences, 1274, 1, (60-67), (2012).
  • , Elimination of autoreactive B cells in humanized SCID mouse model of SLE, European Journal of Immunology, 41, 11, (3301-3311), (2011).
  • , PHARMACOLOGY AND DRUG THERAPY, Textbook of Pediatric Rheumatology, 10.1016/B978-1-4160-6581-4.10006-8, (71-126), (2011).
  • , B cell immunotherapy in autoimmunity – 2010 update, Molecular Immunology, 10.1016/j.molimm.2010.11.021, 48, 11, (1344-1347), (2011).
  • , Epidemiology and management of refractory lupus nephritis, Autoimmunity Reviews, 10.1016/j.autrev.2011.04.032, 10, 11, (655-663), (2011).
  • , B-Cell-Activating Factor and Autoimmune Myasthenia Gravis, Autoimmune Diseases, 10.4061/2011/939520, 2011, (1-10), (2011).
  • , Beyond natural antibodies: the power of in vitro display technologies, Nature Biotechnology, 10.1038/nbt.1791, 29, 3, (245-254), (2011).
  • , Clinical evidence of the role of belimumab in the treatment of systemic lupus erythematosus, Clinical Investigation, 10.4155/cli.11.140, 1, 11, (1555-1561), (2011).
  • , Recombinant proteins in rheumatology – recent advances, New Biotechnology, 10.1016/j.nbt.2011.03.019, 28, 5, (502-510), (2011).
  • , Functional and Clinical Aspects of the B‐Cell‐Activating Factor (BAFF): A Narrative Review, Scandinavian Journal of Immunology, 73, 1, (1-7), (2010).
  • , Belimumab therapy for systemic lupus erythematosus and potential treatment of rheumatoid arthritis, Drug Development Research, 72, 7, (623-633), (2011).
  • , Belimumab: the first US FDA approved biological therapy for systemic lupus erythematosus, International Journal of Clinical Rheumatology, 10.2217/ijr.11.33, 6, 4, (373-377), (2011).
  • , The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study, Public Health Nutrition, 10.1017/S1368980010001783, 14, 04, (709-715), (2010).
  • , Belimumab, Nature Reviews Drug Discovery, 10.1038/nrd3436, 10, 5, (335-336), (2011).
  • , Belimumab, Drugs, 10.2165/11208440-000000000-00000, 71, 18, (2435-2444), (2011).
  • , Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, The Lancet, 10.1016/S0140-6736(10)61354-2, 377, 9767, (721-731), (2011).
  • , Efficacy and Safety Data of Belimumab in Patients with Systemic Lupus Erythematosus, Therapeutic Advances in Musculoskeletal Disease, 10.1177/1759720X11407541, 3, 3, (159-164), (2011).
  • , Serum BAFF level and its correlations with various disease parameters in patients with systemic sclerosis and systemic lupus erythematosus, The Egyptian Rheumatologist, 10.1016/j.ejr.2010.12.001, 33, 1, (45-51), (2011).
  • , Cytokine disturbances in systemic lupus erythematosus, Arthritis Research & Therapy, 10.1186/ar3349, 13, 4, (228), (2011).
  • , Targeting BLyS in rheumatic disease: the sometimes-bumpy road from bench to bedside, Current Opinion in Rheumatology, 10.1097/BOR.0b013e328344c15e, 23, 3, (305-310), (2011).
  • , A phase III, randomized, placebo‐controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus, Arthritis & Rheumatism, 63, 12, (3918-3930), (2011).
  • , B‐cell targeted therapies in human autoimmune diseases: an updated perspective, Immunological Reviews, 237, 1, (264-283), (2010).
  • , Neue Biologika und oral verfügbare neue MedikamenteNew biologics and orally available compounds, Zeitschrift für Rheumatologie, 10.1007/s00393-009-0531-6, 69, 7, (626-632), (2010).
  • , The management of peripheral blood cytopenias in systemic lupus erythematosus, Rheumatology, 10.1093/rheumatology/keq269, 49, 12, (2243-2254), (2010).
  • , Monoclonal antibodies and fusion proteins and their complications: Targeting B cells in autoimmune diseases, Journal of Allergy and Clinical Immunology, 10.1016/j.jaci.2010.02.025, 125, 4, (814-820), (2010).
  • , Effect of long‐term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double‐blind, placebo‐controlled, dose‐ranging study, Arthritis & Rheumatism, 62, 1, (201-210), (2009).
  • , Emerging biotherapies for Sjögren's syndrome, Expert Opinion on Emerging Drugs, 10.1517/14728211003702392, 15, 2, (269-282), (2010).
  • , Raised serum level of APRIL in patients with systemic lupus erythematosus: Correlations with disease activity indices, Clinical Immunology, 10.1016/j.clim.2009.12.012, 135, 1, (118-124), (2010).
  • , Belimumab: A BLyS-Specific Inhibitor for Systemic Lupus Erythematosus, Annals of Pharmacotherapy, 10.1345/aph.1P360, 44, 12, (1955-1961), (2016).
  • , Therapeutic implications of advances in our understanding of transitional B-cell development in humans, Expert Review of Clinical Immunology, 10.1586/eci.10.55, 6, 5, (765-775), (2014).
  • , Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: Past, present, and future, Autoimmunity, 10.3109/08916930903374600, 43, 1, (84-97), (2009).
  • , Belimumab for the treatment of systemic lupus erythematosus, International Journal of Clinical Rheumatology, 10.2217/ijr.10.32, 5, 4, (407-413), (2010).
  • , A20: from ubiquitin editing to tumour suppression, Nature Reviews Cancer, 10.1038/nrc2775, 10, 5, (332-341), (2010).
  • , Aspects of B‐Cell Non‐Hodgkin’s Lymphoma Development: A Transition from Immune‐Reactivity to Malignancy, Scandinavian Journal of Immunology, 69, 5, (387-400), (2009).
  • , Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator, Reproductive Toxicology, 10.1016/j.reprotox.2009.07.002, 28, 4, (443-455), (2009).
  • , Construction, Purification, and Characterization of Anti-BAFF scFv–Fc Fusion Antibody Expressed in CHO/dhfr− Cells, Applied Biochemistry and Biotechnology, 10.1007/s12010-008-8434-6, 157, 3, (562-574), (2008).
  • , A phase II, randomized, double‐blind, placebo‐controlled, dose‐ranging study of belimumab in patients with active systemic lupus erythematosus, Arthritis Care & Research, 61, 9, (1168-1178), (2009).
  • , The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus, Journal of Clinical Investigation, 10.1172/JCI38010, 119, 5, (1066-1073), (2009).
  • , B-Zell-gerichtete Multiple-Sklerose-TherapieTargeting B cells in multiple sclerosis, Der Nervenarzt, 10.1007/s00115-008-2664-2, 80, 2, (190-198), (2009).
  • , Anticytokine therapy impacting on B cells in autoimmune diseases, Current Opinion in Rheumatology, 10.1097/BOR.0b013e32832a0760, 21, 3, (205-210), (2009).
  • , SYSTEMIC LUPUS ERYTHEMATOSUS, Pharmacology and Therapeutics, 10.1016/B978-1-4160-3291-5.50080-9, (1047-1062), (2009).
  • , B-Cell-Directed Therapy for Inflammatory Skin Diseases, Journal of Investigative Dermatology, 10.1038/jid.2008.192, 129, 2, (289-301), (2009).
  • , Cracking the BAFF code, Nature Reviews Immunology, 10.1038/nri2572, 9, 7, (491-502), (2009).
  • , Novel evidence‐based systemic lupus erythematosus responder index, Arthritis Care & Research, 61, 9, (1143-1151), (2009).
  • , B‐lymphocyte contributions to human autoimmune disease, Immunological Reviews, 223, 1, (284-299), (2008).
  • , Actualités et perspectives thérapeutiques du lupus systémique, La Presse Médicale, 10.1016/j.lpm.2007.11.011, 37, 3, (444-459), (2008).
  • , Fully human antibodies from transgenic mouse and phage display platforms, Current Opinion in Immunology, 10.1016/j.coi.2008.06.004, 20, 4, (450-459), (2008).
  • , BAFF-targeting therapy, a promising strategy for treating autoimmune diseases, European Journal of Pharmacology, 10.1016/j.ejphar.2008.08.027, 597, 1-3, (1-5), (2008).
  • , Construction and characterization of an enhanced GFP-tagged anti-BAFF scFv antibody, Applied Microbiology and Biotechnology, 10.1007/s00253-008-1447-9, 79, 3, (423-431), (2008).
  • , Expression, purification and characterization of anti-BAFF antibody secreted from the yeast Pichia pastoris, Biotechnology Letters, 10.1007/s10529-008-9657-x, 30, 6, (1075-1080), (2008).
  • , Lupus systémique : les traitements du futur, La Revue de Médecine Interne, 10.1016/j.revmed.2008.02.013, 29, 9, (718-724), (2008).
  • , Systemic Lupus Erythematosus, New England Journal of Medicine, 10.1056/NEJMra071297, 358, 9, (929-939), (2008).
  • , Therapeutic advances in rheumatology with the use of recombinant proteins, Nature Clinical Practice Rheumatology, 10.1038/ncprheum0909, 4, 11, (605-614), (2008).
  • , Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells, Cytokine, 10.1016/j.cyto.2008.06.005, 44, 1, (44-48), (2008).
  • , Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival, Blood, 10.1182/blood-2007-03-077222, 111, 2, (750-760), (2008).
  • , Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases, Expert Opinion on Biological Therapy, 10.1517/14712598.8.11.1805, 8, 11, (1805-1814), (2008).
  • , Mechanisms for cytotoxic effects of anti–tumor necrosis factor agents on transmembrane tumor necrosis factor α–expressing cells: Comparison among infliximab, etanercept, and adalimumab, Arthritis & Rheumatism, 58, 5, (1248-1257), (2008).
  • , B cell targeted therapy in autoimmunity, Journal of Autoimmunity, 10.1016/j.jaut.2007.02.001, 28, 2-3, (62-68), (2007).
  • , The Future of Biologic Agents in the Treatment of Sjögren’s Syndrome, Clinical Reviews in Allergy & Immunology, 10.1007/s12016-007-8005-6, 32, 3, (292-297), (2007).
  • , Possible therapeutic applications of single-chain antibodies in systemic autoimmune diseases, Expert Opinion on Biological Therapy, 10.1517/14712598.7.5.691, 7, 5, (691-704), (2007).
  • , Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ‐specific autoimmune diseases, Experimental Dermatology, 16, 2, (87-93), (2006).
  • , Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: Results of a multicenter, phase ib, double‐blind, placebo‐controlled, dose‐escalating trial, Arthritis & Rheumatism, 56, 12, (4142-4150), (2007).
  • , B cells in glomerulonephritis: focus on lupus nephritis, Seminars in Immunopathology, 10.1007/s00281-007-0092-1, 29, 4, (337-353), (2007).
  • , Role of B Cells in Pathogenesis of Multiple Sclerosis, The Neurobiology of Multiple Sclerosis, 10.1016/S0074-7742(07)79002-5, (13-42), (2007).
  • , Novel Agents in the Treatment of Waldenström's Macroglobulinemia, Clinical Lymphoma and Myeloma, 10.3816/CLM.2007.s.023, 7, (S199-S206), (2007).
  • , An important role for B-cell activation factor and B cells in the pathogenesis of Sj??gren??s syndrome, Current Opinion in Rheumatology, 10.1097/BOR.0b013e328277ef4c, 19, 5, (406-413), (2007).
  • , The utility of nutraceuticals in the treatment of osteoarthritis, Current Rheumatology Reports, 10.1007/s11926-007-0018-x, 9, 1, (25-30), (2007).
  • , BAFF Antagonist Attenuates the Development of Skin Fibrosis in Tight-Skin Mice, Journal of Investigative Dermatology, 10.1038/sj.jid.5700919, 127, 12, (2772-2780), (2007).
  • , Baff and Rheumatic Autoimmune Disorders: Implications for Disease Management and Therapy, International Journal of Immunopathology and Pharmacology, 10.1177/039463200702000101, 20, 1, (1-8), (2016).
  • , Critical role of monocytes to support normal B cell and diffuse large B cell lymphoma survival and proliferation, Journal of Leukocyte Biology, 82, 3, (567-575), (2007).
  • , BAFF, A newcomer to the lupus party, Lupus, 10.1177/0961203307081512, 16, 9, (699-700), (2016).
  • , sBAFF mutants induce neutralizing antibodies against BAFF, FEBS Letters, 581, 4, (581-586), (2007).
  • , Management of systemic lupus erythematosus: a brief update on recent advances, APLAR Journal of Rheumatology, 9, 4, (387-391), (2006).
  • , New prospects for autoimmune disease therapy: B cells on deathwatch, Arthritis & Rheumatism, 54, 1, (1-9), (2005).
  • , Systemic lupus erythematosus—2005 annus mirabilis?, Nature Clinical Practice Rheumatology, 10.1038/ncprheum0116, 2, 3, (145-152), (2006).
  • , An APRIL to remember: novel TNF ligands as therapeutic targets, Nature Reviews Drug Discovery, 10.1038/nrd1982, 5, 3, (235-246), (2006).
  • , B lymphocytes as therapeutic targets in systemic lupus erythematosus, Expert Opinion on Therapeutic Targets, 10.1517/14728222.10.6.803, 10, 6, (803-815), (2006).
  • , Targeting BAFF: Immunomodulation for autoimmune diseases and lymphomas, Pharmacology & Therapeutics, 10.1016/j.pharmthera.2006.06.002, 112, 3, (774-786), (2006).
  • , Les biothérapies immunomodulatrices: Une révolution thérapeutique dans les maladies auto-immunes, Revue Francophone des Laboratoires, 10.1016/S1773-035X(06)80321-7, 2006, 384, (34-39), (2006).
  • , BLyS and B cell homeostasis, Seminars in Immunology, 10.1016/j.smim.2006.06.001, 18, 5, (318-326), (2006).
  • , B-cell targeting in rheumatoid arthritis and other autoimmune diseases, Nature Reviews Immunology, 10.1038/nri1838, 6, 5, (394-403), (2006).
  • , B cell depletion therapy in systemic rheumatic diseases: Different strokes for different folks?, Clinical Immunology, 10.1016/j.clim.2006.03.010, 121, 1, (1-12), (2006).
  • , Elevated serum BAFF levels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes, Arthritis & Rheumatism, 54, 1, (192-201), (2005).
  • , Role of BAFF and APRIL in human B‐cell chronic lymphocytic leukaemia, Immunology, 118, 3, (281-292), (2006).
  • , Nouvelles approches thérapeutiques des maladies auto-immunes, Revue Neurologique, 10.1016/S0035-3787(06)75152-9, 162, (7-11), (2006).
  • , Biological therapies directed against cells in autoimmune disease, Springer Seminars in Immunopathology, 10.1007/s00281-006-0013-8, 27, 4, (443-456), (2006).
  • , Treatment of systemic lupus erythematosus in 2006, Joint Bone Spine, 10.1016/j.jbspin.2006.09.003, 73, 6, (591-598), (2006).
  • , Chronic Administration of Belimumab, a BLyS Antagonist, Decreases Tissue and Peripheral Blood B-Lymphocyte Populations in Cynomolgus Monkeys: Pharmacokinetic, Pharmacodynamic, and Toxicologic Effects, Toxicological Sciences, 10.1093/toxsci/kfj148, 91, 2, (586-599), (2006).
  • , Development of a compact anti-BAFF antibody in Escherichia coli, Applied Microbiology and Biotechnology, 10.1007/s00253-006-0432-4, 73, 1, (151-157), (2006).
  • , Nouvelles approches thérapeutiques des maladies autoimmunes, La Presse Médicale, 10.1016/S0755-4982(06)74667-X, 35, 4, (709-713), (2006).
  • , Probing a protein-protein interaction by in vitro evolution, Proceedings of the National Academy of Sciences, 10.1073/pnas.0602341103, 103, 20, (7619-7624), (2006).
  • , Le traitement du lupus érythémateux systémique en 2006, Revue du Rhumatisme, 10.1016/j.rhum.2006.09.003, 73, 10-11, (977-984), (2006).
  • , Potent antibody therapeutics by design, Nature Reviews Immunology, 10.1038/nri1837, 6, 5, (343-357), (2006).
  • , Affinity maturation of phage display antibody populations using ribosome display, Journal of Immunological Methods, 10.1016/j.jim.2006.04.002, 313, 1-2, (129-139), (2006).
  • , A Soluble BAFF Antagonist, BR3-Fc, Decreases Peripheral Blood B Cells and Lymphoid Tissue Marginal Zone and Follicular B Cells in Cynomolgus Monkeys, The American Journal of Pathology, 10.2353/ajpath.2006.050600, 168, 2, (476-489), (2006).
  • , Expression and purification of a soluble B lymphocyte stimulator mutant modified with the T-helper cell epitope, Biotechnology Letters, 10.1007/s10529-006-9139-y, 28, 20, (1649-1654), (2006).
  • , B CELL IMMUNOBIOLOGY IN DISEASE: Evolving Concepts from the Clinic, Annual Review of Immunology, 10.1146/annurev.immunol.24.021605.090517, 24, 1, (467-496), (2006).
  • , B cell depletion therapy in rheumatic disease, Best Practice & Research Clinical Rheumatology, 10.1016/j.berh.2006.05.010, 20, 5, (915-928), (2006).
  • , Novel therapeutics for systemic lupus erythematosus, Current Opinion in Rheumatology, 10.1097/01.bor.0000218941.04613.85, 18, 3, (227-235), (2006).
  • , BAFF, APRIL and human B cell disorders, Seminars in Immunology, 10.1016/j.smim.2006.04.004, 18, 5, (305-317), (2006).
  • , B cells in the pathophysiology of autoimmune neurological disorders: A credible therapeutic target, Pharmacology & Therapeutics, 10.1016/j.pharmthera.2006.03.005, 112, 1, (57-70), (2006).
  • , Parallel, high‐throughput purification of recombinant antibodies for in vivo cell assays, Biotechnology and Bioengineering, 94, 5, (931-937), (2006).
  • , In vitro display technologies reveal novel biopharmaceutics, The FASEB Journal, 20, 10, (1599), (2006).
  • , Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans, Nature Genetics, 10.1038/ng1600, 37, 8, (820-828), (2005).
  • , Neutralizing human anti-B-cell-activating factor of the TNF family (BAFF) scFv selected from phage antibody library, Immunology Letters, 10.1016/j.imlet.2005.05.001, 101, 1, (87-94), (2005).
  • , Unraveling TACIt functions, Nature Genetics, 10.1038/ng0805-793, 37, 8, (793-794), (2005).
  • , Molecules involved in T–B co-stimulation and B cell homeostasis: possible targets for an immunological intervention in autoimmunity, Expert Opinion on Biological Therapy, 10.1517/14712598.5.1.S61, 5, sup1, (S61-S71), (2005).
  • , Applications of ribosome display to antibody drug discovery, Expert Opinion on Biological Therapy, 10.1517/14712598.5.1.125, 5, 1, (125-135), (2005).
  • , Novel approaches to therapy for systemic lupus erythematosus: update 2005, Expert Review of Clinical Immunology, 10.1586/1744666X.1.2.223, 1, 2, (223-238), (2014).
  • , The role of BAFF in autoimmune diseases, Japanese Journal of Clinical Immunology, 10.2177/jsci.28.333, 28, 5, (333-342), (2005).
  • , The BAFF/APRIL System in Systemic Autoimmune Diseases with a Special Emphasis on Sjögren's Syndrome, Scandinavian Journal of Immunology, 62, 5, (421-428), (2005).
  • , Depletion of B Cells by a Humanized Anti-CD20 Antibody PRO70769 in Macaca Fascicularis, Journal of Immunotherapy, 10.1097/01.cji.0000155050.03916.04, 28, 3, (212-219), (2005).
  • , Immunothérapies du lupus systémique : innovations et perspectives, Revue du Rhumatisme, 10.1016/j.rhum.2004.12.014, 72, 6, (572-591), (2005).
  • , Theory, targets and therapy in systemic lupus erythematosus, Lupus, 10.1191/0961203305lu2133oa, 14, 3, (181-188), (2016).
  • , Prospects for B-cell-targeted therapy in autoimmune disease, Rheumatology, 10.1093/rheumatology/keh446, 44, 2, (151-156), (2004).
  • , TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity?, Current Opinion in Allergy and Clinical Immunology, 10.1097/01.all.0000191887.89773.cc, 5, 6, (496-503), (2005).
  • , B cells as a therapeutic target in autoimmune diseases, Expert Opinion on Therapeutic Targets, 10.1517/14728222.9.3.431, 9, 3, (431-445), (2005).
  • , Le rituximab : une biothérapie originale dans les maladies auto-immunes, La Revue de Médecine Interne, 10.1016/j.revmed.2004.12.013, 26, 6, (485-500), (2005).
  • , Lupus eritematoso sistémico pediátrico, Anales de Pediatría, 10.1157/13079833, 63, 4, (321-329), (2005).
  • , New therapies and preventive strategies to treat and minimize damage in lupus, Current Rheumatology Reports, 10.1007/s11926-005-0052-5, 7, 6, (457-462), (2005).
  • , The BAFF/APRIL system: life beyond B lymphocytes, Molecular Immunology, 10.1016/j.molimm.2004.06.041, 42, 7, (763-772), (2005).
  • , Biologic Therapies in Clinical Development for the Treatment of Rheumatoid Arthritis, JCR: Journal of Clinical Rheumatology, 10.1097/01.rhu.0000166625.65114.5f, 11, Supplement, (S45-S54), (2005).
  • , Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis, Journal of Neuroimmunology, 10.1016/j.jneuroim.2004.03.017, 152, 1-2, (183-190), (2004).
  • , Novel concepts and treatments for autoimmune disease: ten focal points, Joint Bone Spine, 10.1016/j.jbspin.2004.04.007, 71, 6, (511-517), (2004).
  • , Targeting B lymphocyte stimulator in systemic lupus erythematosus and other autoimmune rheumatic disorders, Expert Opinion on Therapeutic Targets, 10.1517/14728222.8.3.177, 8, 3, (177-189), (2005).
  • , Challenges in bringing the bench to bedside in drug development for sle, Nature Reviews Drug Discovery, 10.1038/nrd1577, 3, 12, (1036-1046), (2004).
  • , Nouveaux concepts et nouveaux traitements dans les maladies auto-immunes : les dix points d'actualité, Revue du Rhumatisme, 10.1016/j.rhum.2004.04.012, 71, 12, (1114-1121), (2004).
  • , Emerging approaches for the therapy of autoimmune and chronic inflammatory disease, Current Opinion in Immunology, 10.1016/j.coi.2004.09.005, 16, 6, (780-786), (2004).
  • , Therapeutic strategies for refractory systemic lupus erythematosus, Drug Discovery Today: Therapeutic Strategies, 10.1016/j.ddstr.2004.11.011, 1, 3, (375-382), (2004).
  • , BLyS—an essential survival factor for B cells: basic biology, links to pathology and therapeutic target, Autoimmunity Reviews, 10.1016/j.autrev.2004.02.001, 3, 5, (368-375), (2004).
  • , A therapeutic role for BLyS antagonists, Lupus, 10.1191/0961203304lu1019oa, 13, 5, (317-322), (2016).
  • , Pathogenic Roles of B Cells in Human Autoimmunity, Immunity, 10.1016/S1074-7613(04)00112-8, 20, 5, (517-527), (2004).
  • , Therapy with biologic agents in SLE, APLAR Journal of Rheumatology, 7, 1, (79-82), (2004).
  • , B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: Longitudinal observations, Arthritis & Rheumatism, 48, 12, (3475-3486), (2003).
  • , Immune complexes containing serum B-cell activating factor and immunoglobulin G correlate with disease activity in systemic lupus erythematosus, Nephrology Dialysis Transplantation, 10.1093/ndt/gfx220, (2017).
  • , The discovery and development of belimumab: the anti-BLyS–lupus connection, Nature Biotechnology, 10.1038/nbt.2076, 30, 1, (69-77), (2012)., (2012).
  • , The BAFF/APRIL system in SLE pathogenesis, Nature Reviews Rheumatology, 10.1038/nrrheum.2014.33, 10, 6, (365-373), (2014)., (2014).
  • , MiR-30a-3p Negatively Regulates BAFF Synthesis in Systemic Sclerosis and Rheumatoid Arthritis Fibroblasts, PLoS ONE, 10.1371/journal.pone.0111266, 9, 10, (e111266), (2014).
  • , Population Pharmacokinetic and Pharmacodynamic Analysis of Belimumab Administered Subcutaneously in Healthy Volunteers and Patients with Systemic Lupus Erythematosus, Clinical Pharmacokinetics, 10.1007/s40262-017-0586-5, (2017).
  • , Comparative efficacy and safety of intravenous or subcutaneous belimumab in combination with standard therapy in patients with active systemic lupus erythematosus: a Bayesian network meta-analysis of randomized controlled trials, Lupus, 10.1177/0961203317713143, (096120331771314), (2017).
  • , Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death, Nature Reviews Molecular Cell Biology, 10.1038/nrm3143, 12, 7, (439-452), (2011).
  • , Pragmatic approaches to therapy for systemic lupus erythematosus, Nature Reviews Rheumatology, 10.1038/nrrheum.2013.157, 10, 2, (97-107), (2013)., (2013).