Feature
Problems And Paradigms: Metaphors and the role of genes in development
Abstract
In describing the flawless regularity of developmental processes and the correlation between changes at certain genetic loci and changes in morphology, biologists frequently employ two metaphors: that genes ‘control’ development, and that genomes embody ‘programs’ for development. Although these metaphors have an admirable sharpness and punch, they lead, when taken literally, to highly distorted pictures of developmental processes. A more balanced, and useful, view of the role of genes in development is that they act as suppliers of the material needs of development and, in some instances, as context‐dependent catalysts of cellular changes, rather than as ‘controllers’ of developmental progress and direction. The consequences of adopting this alternative view of development are discussed.
Citing Literature
Number of times cited: 135
- Richard Gawne, Kenneth Z. McKenna and H. Frederik Nijhout, Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes, BioEssays, 40, 1, (2017).
- Chris Fields and Michael Levin, Multiscale memory and bioelectric error correction in the cytoplasm–cytoskeleton‐membrane system, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 10, 2, (2017).
- J. P. Moreland, In Defense of a Thomistic‐like Dualism, The Blackwell Companion to Substance Dualism, (102-122), (2018).
- Jonathan R. Chubb, Symmetry breaking in development and stochastic gene expression, Wiley Interdisciplinary Reviews: Developmental Biology, 6, 6, (2017).
- Kate Weiner, Paul Martin, Martin Richards and Richard Tutton, Have we seen the geneticisation of society? Expectations and evidence, Sociology of Health & Illness, 39, 7, (989-1004), (2017).
- D.W. Pfennig, Ecological Evolutionary Developmental Biology, Encyclopedia of Evolutionary Biology, 10.1016/B978-0-12-800049-6.00143-8, (474-481), (2016).
- David S. Moore, The Developmental Systems Approach and the Analysis of Behavior, The Behavior Analyst, 39, 2, (243), (2016).
- M.-A. Félix, Phenotypic Evolution With and Beyond Genome Evolution, Genes and Evolution, 10.1016/bs.ctdb.2016.04.002, (291-347), (2016).
- Robert Lickliter and Hunter Honeycutt, Biology, Development, and Human Systems, Handbook of Child Psychology and Developmental Science, (1-46), (2015).
- Miranda R. Waggoner and Tobias Uller, Epigenetic determinism in science and society, New Genetics and Society, 34, 2, (177), (2015).
- Johannes Jaeger, Manfred Laubichler and Werner Callebaut, The Comet Cometh: Evolving Developmental Systems, Biological Theory, 10, 1, (36), (2015).
- Torben Juul Andersen, Interactive Strategy-Making: Combining Central Reasoning with ongoing Learning from Decentralised Responses, Journal of General Management, 40, 4, (69), (2015).
- Ronald L. Simons and Eric T. Klopack, Invited Address: “The Times They Are A-Changin’” Gene Expression, Neuroplasticity, and Developmental Research, Journal of Youth and Adolescence, 44, 3, (573), (2015).
- Stuart A. Newman, Form and function remixed: developmental physiology in the evolution of vertebrate body plans, The Journal of Physiology, 592, 11, (2403-2412), (2014).
- Joseph E. Hannon Bozorgmehr, The role of self-organization in developmental evolution, Theory in Biosciences, 133, 3-4, (145), (2014).
- Daniel J. Nicholson, The machine conception of the organism in development and evolution: A critical analysis, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 48, (162), (2014).
- Rainer R. Schoch, Development and Evolution, Amphibian Evolution, (152-190), (2014).
- Daniel J. Nicholson and Richard Gawne, Rethinking Woodger’s Legacy in the Philosophy of Biology, Journal of the History of Biology, 47, 2, (243), (2014).
- Isaac Salazar-Ciudad and Jukka Jernvall, The Causality Horizon and the Developmental Bases of Morphological Evolution, Biological Theory, 8, 3, (286), (2013).
- Stuart A. Newman and Marta Linde-Medina, Physical Determinants in the Emergence and Inheritance of Multicellular Form, Biological Theory, 10.1007/s13752-013-0116-0, 8, 3, (274-285), (2013).
- Michael J. Denton, Govindasamy Kumaramanickavel and Michael Legge, Cells as irreducible wholes: the failure of mechanism and the possibility of an organicist revival, Biology & Philosophy, 28, 1, (31), (2013).
- Lia Midori Nascimento Meyer, Gilberto Cafezeiro Bomfim and Charbel Niño El-Hani, How to Understand the Gene in the Twenty-First Century?, Science & Education, 22, 2, (345), (2013).
- Nelson R. Cabej, Living and Adapting to Its Own Habitat, Building the Most Complex Structure on Earth, 10.1016/B978-0-12-401667-5.00004-3, (193-238), (2013).
- Marc J. Klowden, Integumentary Systems, Physiological Systems in Insects, 10.1016/B978-0-12-415819-1.00002-7, (89-147), (2013).
- Michael Kosoy, Deepening the Conception of Functional Information in the Description of Zoonotic Infectious Diseases, Entropy, 15, 12, (1929), (2013).
- Séverine Urdy, On the evolution of morphogenetic models: mechano‐chemical interactions and an integrated view of cell differentiation, growth, pattern formation and morphogenesis, Biological Reviews, 87, 4, (786-803), (2012).
- Ronald L. Simons, Steven R.H. Beach and Ashley B. Barr, Differential Susceptibility to Context: A Promising Model of the Interplay of Genes and the Social Environment, Biosociology and Neurosociology, 10.1108/S0882-6145(2012)0000029008, (139-163), (2015).
- A. P. Moczek, The Nature of Nurture and the Future of Evodevo: Toward a Theory of Developmental Evolution, Integrative and Comparative Biology, 52, 1, (108), (2012).
- Vanessa Carvalho dos Santos, Leyla Mariane Joaquim and Charbel Niño El-Hani, Hybrid Deterministic Views About Genes in Biology Textbooks: A Key Problem in Genetics Teaching, Science & Education, 21, 4, (543), (2012).
- Gunver Kienle and Helmut Kiene, From Reductionism to Holism: Systems-oriented Approaches in Cancer Research, Global Advances in Health and Medicine, 10.7453/gahmj.2012.1.5.015, 1, 5, (68-77), (2012).
- Emilie C. Snell‐Rood, Amy Cash, Mira V. Han, Teiya Kijimoto, Justen Andrews and Armin P. Moczek, DEVELOPMENTAL DECOUPLING OF ALTERNATIVE PHENOTYPES: INSIGHTS FROM THE TRANSCRIPTOMES OF HORN‐POLYPHENIC BEETLES, Evolution, 65, 1, (231-245), (2010).
- Nobuko Hagiwara, Sox6, jack of all trades: A versatile regulatory protein in vertebrate development, Developmental Dynamics, 240, 6, (1311-1321), (2011).
- Alessandro Minelli, Animal Development, an Open-Ended Segment of Life, Biological Theory, 6, 1, (4), (2011).
- Rinaldo C. Bertossa, Morphology and behaviour: functional links in development and evolution, Philosophical Transactions of the Royal Society B: Biological Sciences, 366, 1574, (2056), (2011).
- Kathryn E. Hood, Emergence and Constraint in Novel Behavioral Adaptations, Handbook of Developmental Science, Behavior, and Genetics, (323-352), (2010).
- Marta Linde Medina, Two “EvoDevos”, Biological Theory, 5, 1, (7), (2010).
- Rainer R. Schoch, Riedl's burden and the body plan: selection, constraint, and deep time, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 314B, 1, (1-10), (2009).
- Gilbert Gottlieb, Normally Occurring Environmental and Behavioral Influences on Gene Activity, Handbook of Developmental Science, Behavior, and Genetics, (13-37), (2010).
- Tim Andersen, Richard Newman and Tim Otter, Shape Homeostasis in Virtual Embryos, Artificial Life, 15, 2, (161), (2009).
- H Nijhout and Goggy Davidowitz, The Developmental-Physiological Basis of Phenotypic Plasticity, Phenotypic Plasticity of Insects, 10.1201/b10201-14, (2011).
- RÉGIS CHIRAT, RAYMOND ENAY, PIERRE HANTZPERGUE and CHARLES MANGOLD, DEVELOPMENTAL INTEGRATION RELATED TO BUOYANCY CONTROL IN NAUTILOIDS: EVIDENCE FROM UNUSUAL SEPTAL APPROXIMATION AND ONTOGENETIC ALLOMETRIES IN A JURASSIC SPECIES, Palaeontology, 51, 1, (251-261), (2008).
- Marc J. Klowden, Integumentary Systems, Physiological Systems in Insects, 10.1016/B978-012369493-5.50003-1, (75-135), (2008).
- William A. Griffin, Manfred D. Laubichler and Werner Callebaut, Agents, Modeling Processes, and the Allure of Prophecy, Biological Theory, 3, 1, (73), (2008).
- John Mouracade, Aristotelian Hylomorphism and Non-Reductive Materialism, Apeiron, 41, 3, (2008).
- , References, Reviving the Living: Meaning Making in Living Systems, 10.1016/S1571-0831(07)00229-8, (273-284), (2008).
- Lev V Beloussov, Mechanically based generative laws of morphogenesis, Physical Biology, 5, 1, (015009), (2008).
- Yair Neuman, Chapter 2 Who is Reading the Book of Life?, Reviving the Living: Meaning Making in Living Systems, 10.1016/S1571-0831(07)00202-X, (15-17), (2008).
- Adam S. Wilkins, Waddington's Unfinished Critique of Neo-Darwinian Genetics: Then and Now, Biological Theory, 3, 3, (224), (2008).
- E. Baars and T. Baars, Towards a philosophical underpinning of the holistic concept of integrity of organisms within organic agriculture, NJAS - Wageningen Journal of Life Sciences, 54, 4, (463), (2007).
- Lev V. Beloussov and Vassily I. Grabovsky, Information about a form (on the dynamic laws of morphogenesis), Biosystems, 87, 2-3, (204), (2007).
- Gerd B. Müller and Stuart A. Newman, Generation, Integration, Autonomy: Three Steps in the Evolution of Homology, Novartis Foundation Symposium 222 ‐ Homology, (65-79), (2007).
- Willis F. Overton, Developmental Psychology: Philosophy, Concepts, Methodology, Handbook of Child Psychology, (2007).
- Stuart A. Newman and Ramray Bhat, Activator‐inhibitor dynamics of vertebrate limb pattern formation, Birth Defects Research Part C: Embryo Today: Reviews, 81, 4, (305-319), (2008).
- Sebastian Meier and Suat Özbek, A biological cosmos of parallel universes: Does protein structural plasticity facilitate evolution?, BioEssays, 29, 11, (1095-1104), (2007).
- J. B. Edelmann and M. J. Denton, The uniqueness of biological self-organization: challenging the Darwinian paradigm, Biology & Philosophy, 22, 4, (579), (2007).
- S. Urdy and R. Chirat, Snail shell coiling (re‐)evolution and the evo‐devo revolution, Journal of Zoological Systematics and Evolutionary Research, 44, 1, (1-7), (2005).
- Evelyn Fox Keller, Qual foi o impacto do feminismo na ciência?, Cadernos Pagu, 27, (13), (2006).
- Charbel Niño El-Hani, João Queiroz and Claus Emmeche, A semiotic analysis of the genetic information system, Semiotica, 2006, 160, (1), (2006).
- James A. Coffman, Developmental Ascendency: From Bottom-up to Top-down Control, Biological Theory, 1, 2, (165), (2006).
- Benny Johansson and Lars‐Eric Uneståhl, Stress reducing regulative effects of integrated mental training with self‐hypnosis on the secretion of dehydroepiandrosterone sulfate (DHEA‐S) and cortisol in plasma: a pilot study, Contemporary Hypnosis, 23, 3, (101-110), (2006).
- Sonia E. Sultan and Stephen C. Stearns, Environmentally Contingent Variation, Variation, 10.1016/B978-012088777-4/50016-8, (303-332), (2005).
- Evelyn Fox Keller, What impact, if any, has feminism had on science?, Journal of Biosciences, 29, 1, (7), (2004).
- Katrin Weigmann, The code, the text and the language of God, EMBO reports, 5, 2, (116-118), (2004).
- Carmen Knudson-Martin, Gender and Biology, Journal of Feminist Family Therapy, 15, 2-3, (1), (2004).
- Lev V Beloussov, Exploring the dynamic background of the developmental processes and cell reactions with the use of an ultraweak photon emission, Biosystems, 68, 2-3, (199), (2003).
- M.C. Davo and C. Álvarez-Dardet, El genoma y sus metáforas. ¿Detectives, héroes o profetas?, Gaceta Sanitaria, 17, 1, (59), (2003).
- Timothy D. Johnston, Advancing the ecological agenda in developmental science: Wagman and Miller, Developmental Psychobiology, 42, 4, (357-361), (2003).
- Tsvi Sachs, Collective specification of cellular development, BioEssays, 25, 9, (897-903), (2003).
- Chi‐Hua Chiu and Mark W. Hamrick, Evolution and development of the primate limb skeleton, "Evolutionary Anthropology: Issues, News, and Reviews", 11, 3, (94-107), (2002).
- Tsvi Sachs, Consequences of the inherent developmental plasticity of organ and tissue relations, Evolutionary Ecology, 16, 3, (243), (2002).
- Stuart A Newman, Developmental mechanisms: putting genes in their place, Journal of Biosciences, 27, 2, (97), (2002).
- T. M. Freeberg, The Ontogeny of Information: Developmental Systems and Evolution & Evolution’s Eye: A Systems View of the Biology‐Culture Divide, Ethology, 107, 3, (277-279), (2008).
- Jean‐François Colas and Gary C. Schoenwolf, Towards a cellular and molecular understanding of neurulation, Developmental Dynamics, 221, 2, (117-145), (2001).
- Jason Scott Robert, Brian K. Hall and Wendy M. Olson, Bridging the gap between developmental systems theory and evolutionary developmental biology†, BioEssays, 23, 10, (954-962), (2001).
- Giuseppe Fusco, How many processes are responsible for phenotypic evolution?, Evolution & Development, 3, 4, (279-286), (2001).
- Martin Richards, How Distinctive is Genetic Information?, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 32, 4, (663), (2001).
- Stuart A. Newman and Gerd B. Müller, Epigenetic Mechanisms of Character Origination, The Character Concept in Evolutionary Biology, 10.1016/B978-012730055-9/50037-9, (559-579), (2001).
- Jason Scott Robert, Interpreting the homeobox: metaphors of gene action and activation in development and evolution, Evolution & Development, 3, 4, (287-295), (2001).
- Brian K. Hall, The gene is not dead, merely orphaned and seeking a home, Evolution & Development, 3, 4, (225-228), (2001).
- Paul E Griffiths, Developmental Systems Theory, eLS, (2001).
- Stuart A. Newman and Gerd B. Müller, Epigenetic mechanisms of character origination, Journal of Experimental Zoology, 288, 4, (304-317), (2001).
- Neil W. Blackstone, Redox control and the evolution of multicellularity, BioEssays, 22, 10, (947-953), (2000).
- Christian Peter Klingenberg, The art of genes: How organisms make themselves, by Enrico Cohen, Complexity, 5, 4, (46-48), (2000).
- Ron Amundson, Against normal function, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 31, 1, (33), (2000).
- Diego Fernandez‐Duque and Mark L. Johnson, Attention Metaphors: How Metaphors Guide the Cognitive Psychology of Attention, Cognitive Science, 23, 1, (83-116), (2010).
- CHRISTIAN PETER KLINGENBERG, Heterochrony and allometry: the analysis of evolutionary change in ontogeny, Biological Reviews, 73, 1, (79-123), (2007).
- Kathleen K. Smith and Richard A. Schneider, Have gene knockouts caused evolutionary reversals in the mammalian first arch?, BioEssays, 20, 3, (245-255), (1998).
- Jeremy C. Ahouse, The Tragedy of a priori Selectionism: Dennett and Gould on Adaptationism, Biology & Philosophy, 13, 3, (359), (1998).
- Fred A. Keijzer, Doing without representations which specify what to do, Philosophical Psychology, 11, 3, (269), (1998).
- John H. Andrews, BACTERIA AS MODULAR ORGANISMS, Annual Review of Microbiology, 52, 1, (105), (1998).
- J. P. Moreland, Restoring the Substance to the Soul of Psychology, Journal of Psychology and Theology, 26, 1, (29), (1998).
- JEFF J. DOYLE, HOMOPLASY CONNECTIONS AND DISCONNECTIONS: GENES AND SPECIES, MOLECULES AND MORPHOLOGY, Homoplasy, 10.1016/B978-012618030-5/50004-6, (37-66), (1996).
- J. V. Ruch, Tooth Crown Morphogenesis and Cytodifferentiations: Candid Questions and Critical Comments, Connective Tissue Research, 32, 1-4, (1), (1995).
- Richard C. Strohman, Linear genetics, non-linear epigenetics: Complementary approaches to understanding complex diseases, Integrative Physiological and Behavioral Science, 30, 4, (273), (1995).
- Wayne G. Murrell, Colin J. Masters, Roger J. Willis and Denis I. Crane, Chromatin structure and the expression of cardiac genes, Mechanisms of Ageing and Development, 82, 1, (1), (1995).
- Annie Vinter and Pierre Perruchet, Is there an implicit level of representation?, Behavioral and Brain Sciences, 17, 04, (730), (1994).
- Annette Karmiloff-Smith, Précis of Beyond modularity: A developmental perspective on cognitive science, Behavioral and Brain Sciences, 17, 04, (693), (1994).
- Leslie Smith, Modal knowledge and transmodularity, Behavioral and Brain Sciences, 17, 04, (729), (1994).
- Michael Losonsky, Beyond methodological solipsism?, Behavioral and Brain Sciences, 17, 04, (723), (1994).
- Stellan Ohlsson, Representational change, generality versus specificity, and nature versus nurture: Perennial issues in cognitive research, Behavioral and Brain Sciences, 17, 04, (724), (1994).
- David R. Olson, Where redescriptions come from, Behavioral and Brain Sciences, 17, 04, (725), (1994).
- Robert L. Campbell, What's getting redescribed?, Behavioral and Brain Sciences, 17, 04, (710), (1994).
- Norman H. Freeman, Redescription of intentionality, Behavioral and Brain Sciences, 17, 04, (717), (1994).
- Ellin Kofsky Scholnick, Redescribing development, Behavioral and Brain Sciences, 17, 04, (727), (1994).
- Antonella Carassa and Maurizio Tirassa, Representational redescription and cognitive architectures, Behavioral and Brain Sciences, 17, 04, (711), (1994).
- Beatrice de Gelder, The risks of rationalising cognitive development, Behavioral and Brain Sciences, 17, 04, (713), (1994).
- Julie C. Rutkowska, Situating representational redescriptionin infants' pragmatic knowledge, Behavioral and Brain Sciences, 17, 04, (726), (1994).
- Deanna Kuhn, The power of explicit knowing, Behavioral and Brain Sciences, 17, 04, (722), (1994).
- Paul Bloom and Karen Wynn, The real problem with constructivism, Behavioral and Brain Sciences, 17, 04, (707), (1994).
- Terry Dartnall, Redescribing redescription, Behavioral and Brain Sciences, 17, 04, (712), (1994).
- Timothy D. Johnston, Genes, development, and the “innate” structure of the mind, Behavioral and Brain Sciences, 17, 04, (721), (1994).
- Thomas R. Shultz, The challenge of representational redescription, Behavioral and Brain Sciences, 17, 04, (728), (1994).
- P. J. Hampson, Representational redescription, memory, and connectionism, Behavioral and Brain Sciences, 17, 04, (721), (1994).
- Philip David Zelazo, From the decline of development to the ascent of consciousness, Behavioral and Brain Sciences, 17, 04, (731), (1994).
- Péter Bodor and Csaba Pléh, A Fodorian guide to Switzerland: Jung and Piaget combined?, Behavioral and Brain Sciences, 17, 04, (709), (1994).
- Annette Karmiloff-Smith, Transforming a partially structured brain into a creative mind, Behavioral and Brain Sciences, 17, 04, (732), (1994).
- Margaret A. Boden, Representational redescription: A question of sequence, Behavioral and Brain Sciences, 17, 04, (708), (1994).
- Merlin Donald, Representation: Ontogenesis and phylogenesis, Behavioral and Brain Sciences, 17, 04, (714), (1994).
- David Estes, Developmental psychology for the twenty-first century, Behavioral and Brain Sciences, 17, 04, (715), (1994).
- Susan H. Foster-Cohen, Arguments against linguistic “modularization”, Behavioral and Brain Sciences, 17, 04, (716), (1994).
- Rick Grush, Beyond connectionist versus classical Al: A control theoretic perspective on development and cognitive science, Behavioral and Brain Sciences, 17, 04, (720), (1994).
- Gregory A. Wray, Developmental evolution: New paradigms and paradoxes, Developmental Genetics, 15, 1, (1-6), (2005).
- Brent D. Mishler, Cladistic analysis of molecular and morphological data, American Journal of Physical Anthropology, 94, 1, (143-156), (2005).
- Jonathan Marks and R. Brent Lyles, Rethinking genes, "Evolutionary Anthropology: Issues, News, and Reviews", 3, 4, (139-146), (2005).
- R. W. Leslie and W. S. Grant, Meristic and morphometric variation among anglerfish of the genus Lophius (Lophiiformes), Journal of Zoology, 232, 4, (565-584), (2009).
- George Graham, Dissociation, self-attribution, and redescription, Behavioral and Brain Sciences, 17, 04, (719), (1994).
- Yoram Schiffmann, Instability of the Homogeneous State as the Source of Localization, Epigenesis, Differentiation, and Morphogenesis, , 10.1016/S0074-7696(08)62202-0, (309-375), (1994).
- Steven R. Quartz and Terrence J. Sejnowski, Beyond modularity: Neural evidence for constructivist principles in development, Behavioral and Brain Sciences, 17, 04, (725), (1994).
- V. Louise Roth, WITHIN AND BETWEEN ORGANISMS: REPLICATORS, LINEAGES, AND HOMOLOGUES, Homology, 10.1016/B978-0-08-057430-1.50015-9, (301-337), (1994).
- Susan Goldin-Meadow and Martha Wagner Alibali, Do you have to be right to redescribe?, Behavioral and Brain Sciences, 17, 04, (718), (1994).
- PAULA M. MABEE, Phylogenetic interpretation of ontogenetic change: sorting out the actual and artefactual in an empirical case study of centrarchid fishes, Zoological Journal of the Linnean Society, 107, 3, (175-291), (2008).
- LIA ETTINGER and FANNY DOLJANSKI, ON THE GENERATION OF FORM BY THE CONTINUOUS INTERACTIONS BETWEEN CELLS AND THEIR EXTRACELLULAR MATRIX, Biological Reviews, 67, 4, (459-489), (2008).
- Stuart A. Newman, Generic physical mechanisms of morphogenesis and pattern formation as determinants in the evolution of multicellular organization, Journal of Biosciences, 17, 3, (193), (1992).
- Kelly C. Smith, Neo-rationalism versus neo-Darwinism: Integrating development and evolution, Biology & Philosophy, 7, 4, (431), (1992).
- Arnold De Loof, Problems and paradigms. All animals develop from a blastula: Consequences of an undervalued definition for thinking on development, BioEssays, 14, 8, (573-575), (2005).
