Review
History of Cannabis and Its Preparations in Saga, Science, and Sobriquet
Abstract
Cannabis sativa L. is possibly one of the oldest plants cultivated by man, but has remained a source of controversy throughout its history. Whether pariah or panacea, this most versatile botanical has provided a mirror to medicine and has pointed the way in the last two decades toward a host of medical challenges from analgesia to weight loss through the discovery of its myriad biochemical attributes and the endocannabinoid system wherein many of its components operate.
This study surveys the history of cannabis, its genetics and preparations. A review of cannabis usage in Ancient Egypt will serve as an archetype, while examining first mentions from various Old World cultures and their pertinence for contemporary scientific investigation. Cannabis historians of the past have provided promising clues to potential treatments for a wide array of currently puzzling medical syndromes including chronic pain, spasticity, cancer, seizure disorders, nausea, anorexia, and infectious disease that remain challenges for 21st century medicine. Information gleaned from the history of cannabis administration in its various forms may provide useful points of departure for research into novel delivery techniques and standardization of cannabis‐based medicines that will allow their prescription for treatment of these intractable medical conditions.
Citing Literature
Number of times cited according to CrossRef: 183
- Kevin M. Takakuwa, A history of the Society of Cannabis Clinicians and its contributions and impact on the US medical cannabis movement, International Journal of Drug Policy, 10.1016/j.drugpo.2020.102749, 79, (102749), (2020).
- Stephen PH Alexander, Barriers to the wider adoption of medicinal Cannabis , British Journal of Pain, 10.1177/2049463720922884, 14, 2, (122-132), (2020).
- Dermot P. Maher, Bunty J. Shah, Yakov Vorobeychik, Opioid and Non-opioid Therapy, Spine Pain Care, 10.1007/978-3-030-27447-4, (231-257), (2020).
- E. A. Carlini, Lucas O. Maia, Plant and Fungal Hallucinogens as Toxic and Therapeutic Agents, Plant Toxins, 10.1007/978-94-007-6728-7_6-2, (1-44), (2020).
- Kent A. Owusu, Lina Saliba, Abdalla A. Ammar, Mahmoud A. Ammar, Jeffrey Mucksavage, Application of Cannabinoids in Neurosciences, Critical Care Nursing Quarterly, 10.1097/CNQ.0000000000000303, 43, 2, (216-231), (2020).
- Melody Chang, Medical Marijuana (Cannabinoid-Derived Products) for Cancer Patients, Oncology Issues, 10.1080/10463356.2020.1747240, 35, 3, (38-44), (2020).
- P. Romero, A. Peris, K. Vergara, J.T. Matus, Comprehending and Improving Cannabis Specialized Metabolism in the Systems Biology Era, Plant Science, 10.1016/j.plantsci.2020.110571, (110571), (2020).
- Matthew Chung, Salahadin Abdi, Cannabis in Oncology and Symptom Management, Cannabis in Medicine, 10.1007/978-3-030-45968-0, (325-343), (2020).
- Tyler E. Gaston, Jerzy P. Szaflarski, Allen C. Bowling, Ying Liu, Tristan Seawalt, Maureen A. Leehey, E. Lee Nelson, Sharad Rajpal, Alan T. Villavicencio, Andrew Bauer, Sigita Burneikiene, Cannabinoids in Neurologic Conditions, Cannabis in Medicine, 10.1007/978-3-030-45968-0, (231-312), (2020).
- Sarah Nelson, Irina Zhushchikhovskaya, Tao Li, Mark Hudson, Martine Robbeets, Tracing population movements in ancient East Asia through the linguistics and archaeology of textile production, Evolutionary Human Sciences, 10.1017/ehs.2020.4, 2, (2020).
- Grégorio Crini, Eric Lichtfouse, Gilles Chanet, Nadia Morin-Crini, Traditional and New Applications of Hemp, Sustainable Agriculture Reviews 42, 10.1007/978-3-030-41384-2_2, (37-87), (2020).
- Godfrey Pearlson, Ethnobotany, botany, and archaeology, Weed Science, 10.1016/B978-0-12-818174-4.00004-5, (39-58), (2020).
- Godfrey Pearlson, Medical marijuana and clinical trials, Weed Science, 10.1016/B978-0-12-818174-4.00010-0, (243-260), (2020).
- Jerry Zweigenbaum, Agustin Pierri, Marihuana safety: Potency of cannabinoids, pesticide residues, and mycotoxin in one analysis by LC/MS/MS, , 10.1016/bs.coac.2020.04.008, (2020).
- Toby Seddon, William Floodgate, , Regulating Cannabis, 10.1007/978-3-030-52927-7_1, (1), (2020).
- H. P. Vasantha Rupasinghe, Amy Davis, Shanthanu K. Kumar, Beth Murray, Valtcho D. Zheljazkov, Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals, Molecules, 10.3390/molecules25184078, 25, 18, (4078), (2020).
- Crist N. Filer, Minnesota wild hemp: a crucial botanical source in early cannabinoid discovery, Journal of Cannabis Research, 10.1186/s42238-020-00031-3, 2, 1, (2020).
- Yann Chye, Rebecca Kirkham, Valentina Lorenzetti, Eugene McTavish, Nadia Solowij, Murat Yücel, Cannabis, cannabinoids, and brain morphology – A review of the evidence, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 10.1016/j.bpsc.2020.07.009, (2020).
- Matthew Morrow, The Effects of Cannabinoid Use on Acute Orthopaedic Pain, JBJS Journal of Orthopaedics for Physician Assistants, 10.2106/JBJS.JOPA.20.00006, 8, 2, (e0006-e0006), (2020).
- Petter Grahl Johnstad, Cannabis as entheogen: survey and interview data on the spiritual use of cannabis, Journal of Cannabis Research, 10.1186/s42238-020-00032-2, 2, 1, (2020).
- Thies Gülck, Birger Lindberg Møller, Phytocannabinoids: Origins and Biosynthesis, Trends in Plant Science, 10.1016/j.tplants.2020.05.005, (2020).
- Debojyoti Bag, Aliya Tabassum, Nidhi Arora, Praveen Kumar Verma, Sanghapal D. Sawant, Medicinal Applications of Cannabidiol from the Genus Cannabis L., Botanical Leads for Drug Discovery, 10.1007/978-981-15-5917-4, (201-241), (2020).
- John Howard, Jamie Osborne, Cannabis and work: Need for more research, American Journal of Industrial Medicine, 10.1002/ajim.23170, 63, 11, (963-972), (2020).
- Paweł Rodziewicz, Oliver Kayser, Cannabis sativa L. –Cannabis, Medicinal, Aromatic and Stimulant Plants, 10.1007/978-3-030-38792-1_3, (233-264), (2020).
- Roy Upton, Cannabis (Marijuana) and Cannabinoids, Textbook of Natural Medicine, 10.1016/B978-0-323-43044-9.00061-3, (470-483.e5), (2020).
- Kamini Vijeepallam, Vijayapandi Pandy, DharmaniDevi Murugan, MuraliNaidu Kuppusamy, Methanolic extract of Mitragyna speciosa Korth leaf exhibits place preference only at higher doses in mice , Pharmacognosy Magazine, 10.4103/pm.pm_62_20, 16, 71, (449), (2020).
- Bruno Halioua, Alexis Astruc, Didier Bouhassira, Histoire du cannabis médical, La Presse Médicale Formation, 10.1016/j.lpmfor.2020.09.018, (2020).
- Bogdan Ionel Tamba, Gabriela Dumitrita Stanciu, Cristina Mariana Urîtu, Elena Rezus, Raluca Stefanescu, Cosmin Teodor Mihai, Andrei Luca, Gabriela Rusu-Zota, Maria-Magdalena Leon-Constantin, Elena Cojocaru, Bogdan Gafton, Teodora Alexa-Stratulat, Challenges and Opportunities in Preclinical Research of Synthetic Cannabinoids for Pain Therapy, Medicina, 10.3390/medicina56010024, 56, 1, (24), (2020).
- Yannick Nuapia, Hlanganani Tutu, Luke Chimuka, Ewa Cukrowska, Selective Extraction of Cannabinoid Compounds from Cannabis Seed Using Pressurized Hot Water Extraction, Molecules, 10.3390/molecules25061335, 25, 6, (1335), (2020).
- Lisa Burgel, Jens Hartung, Daniele Schibano, Simone Graeff-Hönninger, Impact of Different Phytohormones on Morphology, Yield and Cannabinoid Content of Cannabis sativa L., Plants, 10.3390/plants9060725, 9, 6, (725), (2020).
- Theresa Schmidt, Annemarie Elisabeth Kramell, Florian Oehler, Ralph Kluge, Dieter Demske, Pavel E Tarasov, René Csuk, Identification and quantification of cannabinol as a biomarker for local hemp retting in an ancient sedimentary record by HPTLC-ESI-MS, Analytical and Bioanalytical Chemistry, 10.1007/s00216-020-02492-0, (2020).
- Louisa Lyon, THC and CBD: is medical cannabis over-hyped or under-prescribed?, Brain, 10.1093/brain/awaa066, (2020).
- Attila Szabo, Ibrahim A. Akkouh, Thor Ueland, Trine Vik Lagerberg, Ingrid Dieset, Thomas Bjella, Pål Aukrust, Stephanie Le Hellard, Anne-Kristin Stavrum, Ingrid Melle, Ole A. Andreassen, Srdjan Djurovic, Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder, Frontiers in Psychiatry, 10.3389/fpsyt.2020.00642, 11, (2020).
- Christian Krill, Simone Rochfort, German Spangenberg, A High-Throughput Method for the Comprehensive Analysis of Terpenes and Terpenoids in Medicinal Cannabis Biomass, Metabolites, 10.3390/metabo10070276, 10, 7, (276), (2020).
- Flavio A. Franchina, Lena M. Dubois, Jean-François Focant, In-Depth Cannabis Multiclass Metabolite Profiling Using Sorptive Extraction and Multidimensional Gas Chromatography with Low- and High-Resolution Mass Spectrometry, Analytical Chemistry, 10.1021/acs.analchem.0c01301, (2020).
- R. G. Akzhigitov, K. I. Pochigayeva, F. K. Rider, A. M. Teplyshova, S. I. Dedayev, I. A. Shpak, E. V. Pashnin, A. B. Gekht, The use of cannabinoids in epilepsy as an example: medical, social, and legal aspects, Neurology, Neuropsychiatry, Psychosomatics, 10.14412/2074-2711-2020-4-125-130, 12, 4, (125-130), (2020).
- Grégorio Crini, Eric Lichtfouse, Gilles Chanet, Nadia Morin-Crini, Applications of hemp in textiles, paper industry, insulation and building materials, horticulture, animal nutrition, food and beverages, nutraceuticals, cosmetics and hygiene, medicine, agrochemistry, energy production and environment: a review, Environmental Chemistry Letters, 10.1007/s10311-020-01029-2, (2020).
- Kevin M. Takakuwa, Jeffrey Y. Hergenrather, Frances S. Shofer, Raquel M. Schears, The Impact of Medical Cannabis on Intermittent and Chronic Opioid Users with Back Pain: How Cannabis Diminished Prescription Opioid Usage, Cannabis and Cannabinoid Research, 10.1089/can.2019.0039, (2020).
- Garnet McRae, Jeremy E. Melanson, Quantitative determination and validation of 17 cannabinoids in cannabis and hemp using liquid chromatography-tandem mass spectrometry, Analytical and Bioanalytical Chemistry, 10.1007/s00216-020-02862-8, (2020).
- Madison A. Bell, Jules M. Blais, Paleolimnology in support of archeology: a review of past investigations and a proposed framework for future study design, Journal of Paleolimnology, 10.1007/s10933-020-00156-8, (2020).
- Lindsey D. Thiessen, Tyler Schappe, Sarah Cochran, Kristin Hicks, Angela R. Post, Surveying for Potential Diseases and Abiotic Disorders of Industrial Hemp ( Cannabis sativa ) Production , Plant Health Progress, 10.1094/PHP-03-20-0017-RS, (321-332), (2020).
- William Leonard, Pangzhen Zhang, Danyang Ying, Zhongxiang Fang, Hempseed in food industry: Nutritional value, health benefits, and industrial applications, Comprehensive Reviews in Food Science and Food Safety, 10.1111/1541-4337.12517, 19, 1, (282-308), (2019).
- Daniela Neuhofer, Sade M. Spencer, Vivian C. Chioma, Lauren N. Beloate, Danielle Schwartz, Peter W. Kalivas, The loss of NMDAR‐dependent LTD following cannabinoid self‐administration is restored by positive allosteric modulation of CB1 receptors, Addiction Biology, 10.1111/adb.12843, 25, 6, (2019).
- Anna L. Schwabe, Mitchell E. McGlaughlin, Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: implications for a budding industry, Journal of Cannabis Research, 10.1186/s42238-019-0001-1, 1, 1, (2019).
- Paola Minghetti, Valentina Marini, Viviana Zaccara, Antonella Casiraghi, Regulation for Prescribing and Dispensing System of Cannabis: the Italian Case, Current Bioactive Compounds, 10.2174/1573407214666181011120031, 15, 2, (196-200), (2019).
- Kalekristos Yohannes Woldemariam, Other Typical Pseudo-cereals in Diet, Bioactive Factors and Processing Technology for Cereal Foods, 10.1007/978-981-13-6167-8, (233-259), (2019).
- Michelle Markle, Donna G. Nativio, Medical Marijuana in the Pediatric Population With Epilepsy—What You Should Know, Journal of Pediatric Health Care, 10.1016/j.pedhc.2019.03.002, (2019).
- Cristina Tassorelli, Rosaria Greco, Stephen D. Silberstein, The endocannabinoid system in migraine, Current Opinion in Neurology, 10.1097/WCO.0000000000000688, 32, 3, (405-412), (2019).
- Michael P. Smoker, Ken Mackie, Christopher C. Lapish, Stephen L. Boehm, Self-administration of edible Δ9-tetrahydrocannabinol and associated behavioral effects in mice, Drug and Alcohol Dependence, 10.1016/j.drugalcdep.2019.02.020, (2019).
- Nicolas Van Elsué, Michel Yegles, Influence of cosmetic hair treatments on cannabinoids in hair: bleaching, perming and permanent coloring, Forensic Science International, 10.1016/j.forsciint.2019.02.030, (2019).
- Nirit Bernstein, Jonathan Gorelick, Sraya Koch, Interplay between chemistry and morphology in medical cannabis (Cannabis sativa L.), Industrial Crops and Products, 10.1016/j.indcrop.2018.11.039, 129, (185-194), (2019).
- Juan A. Páez, Nuria E. Campillo, Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer’s Disease and Less Well-Known Diseases, Current Medicinal Chemistry, 10.2174/0929867325666180226095132, 26, 18, (3300-3340), (2019).
- Miriam Schneider, Eva Hoch, Roland Simon, Tim Pfeiffer-Gerschel, Ludwig Kraus, Winfried Häuser, Beat Lutz, Cannabis, Cannabinoide und das Endocannabinoidsystem, Cannabis: Potenzial und Risiko, 10.1007/978-3-662-57291-7, (1-36), (2019).
- Niranjan Aryal, Debbie Figueroa Orellana, Jamal Bouie, Distribution of cannabinoid synthase genes in non-Cannabis organisms, Journal of Cannabis Research, 10.1186/s42238-019-0008-7, 1, 1, (2019).
- Rebecca Thompson, Katherine DeJong, Jamie Lo, Marijuana Use in Pregnancy, Obstetrical & Gynecological Survey, 10.1097/OGX.0000000000000685, 74, 7, (415-428), (2019).
- Philippe Lucas, Eric P. Baron, Nick Jikomes, Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients, Harm Reduction Journal, 10.1186/s12954-019-0278-6, 16, 1, (2019).
- Sonja Elsaid, Stefan Kloiber, Bernard Le Foll, Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings, Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside, 10.1016/bs.pmbts.2019.06.005, (25-75), (2019).
- Afraz Subratti, Lorale J. Lalgee, Nigel K. Jalsa, Liquified dimethyl ether (DME): A green solvent for the extraction of hemp (Cannabis sativa L.) seed oil, Sustainable Chemistry and Pharmacy, 10.1016/j.scp.2019.100144, 12, (100144), (2019).
- R.A. Williams, D.W. Williams, Cannabinoids‐Human Physiology and Agronomic Principles for Production, Industrial Hemp as a Modern Commodity Crop, undefined, (73-91), (2019).
- Daniela Vergara, Ezra L Huscher, Kyle G Keepers, Robert M Givens, Christian G Cizek, Anthony Torres, Reggie Gaudino, Nolan C Kane, Gene copy number is associated with phytochemistry in Cannabis sativa, AoB PLANTS, 10.1093/aobpla/plz074, 11, 6, (2019).
- Lesley G. Campbell, Steve G. U. Naraine, Jaimie Dusfresne, Phenotypic plasticity influences the success of clonal propagation in industrial pharmaceutical Cannabis sativa, PLOS ONE, 10.1371/journal.pone.0213434, 14, 3, (e0213434), (2019).
- Christopher W. Cunningham, Plant-Based Modulators of Endocannabinoid Signaling, Journal of Natural Products, 10.1021/acs.jnatprod.8b00874, (2019).
- Tomasz Dzierżanowski, Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence, Cancers, 10.3390/cancers11020129, 11, 2, (129), (2019).
- Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, James C. Church, Tom P. Freeman, Mahmoud A. ElSohly, New trends in cannabis potency in USA and Europe during the last decade (2008–2017), European Archives of Psychiatry and Clinical Neuroscience, 10.1007/s00406-019-00983-5, (2019).
- Chris S. Duvall, A brief agricultural history of cannabis in Africa, from prehistory to canna-colony, EchoGéo, 10.4000/echogeo.17599, 48, (2019).
- Kevin M. Takakuwa, Raquel M. Schears, A History of the US Medical Cannabis Movement and Its Importance to Pediatricians: Science Versus Politics in Medicine’s Greatest Catch-22, Clinical Pediatrics, 10.1177/0009922819875550, (000992281987555), (2019).
- Samuel D. Banister, Jonathon C. Arnold, Mark Connor, Michelle Glass, Iain S. McGregor, Dark Classics in Chemical Neuroscience: Δ 9 -Tetrahydrocannabinol , ACS Chemical Neuroscience, 10.1021/acschemneuro.8b00651, (2019).
- Ethan B. Russo, The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain, Frontiers in Plant Science, 10.3389/fpls.2018.01969, 9, (2019).
- Ramia Z. Albakain, Yahya S. Al-Degs, James V. Cizdziel, Mahmoud A. Elsohly, Comprehensive classification of USA cannabis samples based on chemical profiles of major cannabinoids and terpenoids, Journal of Liquid Chromatography & Related Technologies, 10.1080/10826076.2019.1701015, (1-13), (2019).
- Amna Shaikh, Sarah Money, Cannabinoids and Pain Management: an Insight into Recent Advancements, Current Emergency and Hospital Medicine Reports, 10.1007/s40138-019-00199-w, (2019).
- S. Pisanti, M. Bifulco, Medical Cannabis: A plurimillennial history of an evergreen, Journal of Cellular Physiology, 10.1002/jcp.27725, 234, 6, (8342-8351), (2018).
- Thomas J. Sheehan, Hilary J. Hamnett, Richard Beasley, Paul S. Fitzmaurice, Chemical and physical variations of cannabis smoke from a variety of cannabis samples in New Zealand, Forensic Sciences Research, 10.1080/20961790.2018.1445937, 4, 2, (168-178), (2018).
- Yuefang Zhou, Shanshan Wang, Jianbo Ji, Hongxiang Lou, Peihong Fan, Hemp ( Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice , ACS Omega, 10.1021/acsomega.8b02250, 3, 11, (15988-15995), (2018).
- Carmen del Río, Estrella Millán, Víctor García, Giovanni Appendino, Jim DeMesa, Eduardo Muñoz, The endocannabinoid system of the skin. A potential approach for the treatment of skin disorders, Biochemical Pharmacology, 10.1016/j.bcp.2018.08.022, (2018).
- J. Daniel Lafreniere, Melanie E.M. Kelly, Potential for endocannabinoid system modulation in ocular pain and inflammation: filling the gaps in current pharmacological options, Neuronal Signaling, 10.1042/NS20170144, 2, 4, (NS20170144), (2018).
- A. Chicca, M. A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E. M. Carreira, J. Gertsch, Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high, Science Advances, 10.1126/sciadv.aat2166, 4, 10, (eaat2166), (2018).
- Yuefang Zhou, Shanshan Wang, Hongxiang Lou, Peihong Fan, Chemical constituents of hemp (Cannabis sativa L.) seed with potential anti-neuroinflammatory activity, Phytochemistry Letters, 10.1016/j.phytol.2017.11.013, 23, (57-61), (2018).
- Deron Caplan, Jonathan Stemeroff, Mike Dixon, Youbin Zheng, Vegetative propagation of cannabis by stem cuttings: effects of leaf number, cutting position, rooting hormone, and leaf tip removal, Canadian Journal of Plant Science, 10.1139/cjps-2018-0038, 98, 5, (1126-1132), (2018).
- Sara Anna Bonini, Marika Premoli, Simone Tambaro, Amit Kumar, Giuseppina Maccarinelli, Maurizio Memo, Andrea Mastinu, Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history, Journal of Ethnopharmacology, 10.1016/j.jep.2018.09.004, 227, (300-315), (2018).
- Caroline A. MacCallum, Ethan B. Russo, Practical considerations in medical cannabis administration and dosing, European Journal of Internal Medicine, 10.1016/j.ejim.2018.01.004, 49, (12-19), (2018).
- Grace Blest-Hopley, Vincent Giampietro, Sagnik Bhattacharyya, Residual effects of cannabis use in adolescent and adult brains — A meta-analysis of fMRI studies, Neuroscience & Biobehavioral Reviews, 10.1016/j.neubiorev.2018.03.008, 88, (26-41), (2018).
- David Neubauer, Mirjana Perković Benedik, Damjan Osredkar, Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia, Epilepsy & Behavior, 10.1016/j.yebeh.2018.02.009, 81, (79-85), (2018).
- Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš, The Anti-Inflammatory Properties of Terpenoids from Cannabis , Cannabis and Cannabinoid Research, 10.1089/can.2018.0014, 3, 1, (282-290), (2018).
- Paul E. Sanmartin, Kamil Detyniecki, Cannabidiol for Epilepsy: New Hope on the Horizon?, Clinical Therapeutics, 10.1016/j.clinthera.2018.07.020, 40, 9, (1438-1441), (2018).
- Cinzia Citti, Daniela Braghiroli, Maria Angela Vandelli, Giuseppe Cannazza, Pharmaceutical and biomedical analysis of cannabinoids: A critical review, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2017.06.003, 147, (565-579), (2018).
- M.A. Fitzcharles, E. Eisenberg, Medical cannabis: A forward vision for the clinician, European Journal of Pain, 10.1002/ejp.1185, 22, 3, (485-491), (2018).
- David Caldicott, The Case For, Journal of Pharmacy Practice and Research, 10.1002/jppr.1504, 48, 5, (475-477), (2018).
- Ju Lee Oei, Adult consequences of prenatal drug exposure, Internal Medicine Journal, 10.1111/imj.13658, 48, 1, (25-31), (2018).
- Rong Guo, Hongyan Guo, Qingying Zhang, Mengbi Guo, Yanping Xu, Min Zeng, Pin Lv, Xuan Chen, Ming Yang, Evaluation of reference genes for RT-qPCR analysis in wild and cultivated Cannabis , Bioscience, Biotechnology, and Biochemistry, 10.1080/09168451.2018.1506253, 82, 11, (1902-1910), (2018).
- Richard D. Richins, Laura Rodriguez-Uribe, Kiah Lowe, Rebekah Ferral, Mary A. O’Connell, Accumulation of bioactive metabolites in cultivated medical Cannabis, PLOS ONE, 10.1371/journal.pone.0201119, 13, 7, (e0201119), (2018).
- Ethan B. Russo, Cannabis Therapeutics and the Future of Neurology, Frontiers in Integrative Neuroscience, 10.3389/fnint.2018.00051, 12, (2018).
- Sheahan Bestel, Yingjian Bao, Hua Zhong, Xingcan Chen, Li Liu, Wild plant use and multi-cropping at the early Neolithic Zhuzhai site in the middle Yellow River region, China, The Holocene, 10.1177/0959683617721328, 28, 2, (195-207), (2017).
- I Patrick Saoud, Jessica Babikian, Nivin Nasser, Samer Monzer, Effect of cannabis oil on growth performance, haematology and metabolism of Nile Tilapia Oreochromis niloticus, Aquaculture Research, 10.1111/are.13512, 49, 2, (809-815), (2017).
- Marcella Pesce, Alessandra D'Alessandro, Osvaldo Borrelli, Stefano Gigli, Luisa Seguella, Rosario Cuomo, Giuseppe Esposito, Giovanni Sarnelli, Endocannabinoid‐related compounds in gastrointestinal diseases, Journal of Cellular and Molecular Medicine, 10.1111/jcmm.13359, 22, 2, (706-715), (2017).
- Bakht Nasir, Humaira Fatima, Madiha Ahmed, Abdul-Rehman Phull, undefined Ihsan-ul-Haq, Cannabis: A Prehistoric Remedy for the Deficits of Existing and Emerging Anticancer Therapies, Journal of Exploratory Research in Pharmacology, 10.14218/JERP.2017.00012, 2, 3, (82-93), (2017).
- Justin T. Fischedick, Identification of Terpenoid Chemotypes Among High (−)- trans -Δ 9 - Tetrahydrocannabinol-Producing Cannabis sativa L. Cultivars , Cannabis and Cannabinoid Research, 10.1089/can.2016.0040, 2, 1, (34-47), (2017).
- Michael A. Schafroth, Erick M. Carreira, Synthesis of Phytocannabinoids, Phytocannabinoids, 10.1007/978-3-319-45541-9_2, (37-59), (2017).
- Christian Lehmann, Juan Zhou, Charles C. Caldwell, Sepsis: Staging and Potential Future Therapies, Colloquium Series on Integrated Systems Physiology: From Molecule to Function, 10.4199/C00157ED1V01Y201708ISP077, 9, 4, (i-91), (2017).
- George B. Richardson, Ching-Chen Chen, Chia-Liang Dai, Christopher M. Swoboda, Joseph L. Nedelec, Wei-Wen Chen, Substance use and mating success, Evolution and Human Behavior, 10.1016/j.evolhumbehav.2016.06.006, 38, 1, (48-57), (2017).
- Brooke K. O'Connell, David Gloss, Orrin Devinsky, Cannabinoids in treatment-resistant epilepsy: A review, Epilepsy & Behavior, 10.1016/j.yebeh.2016.11.012, 70, (341-348), (2017).
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