Article
Selektive Phosphorylierung von Nucleosiden
Abstract
Phosphorsäure‐bis‐[β.β.β‐trichlor‐äthylester]‐chlorid eignet sich zur selektiven Phosphorylierung von Nucleosiden in 5′‐Stellung. Die entstehenden Nucleosid‐5′‐bis‐[β.β.β‐trichloräthyl]‐phosphate lassen sich in Ausbeuten von 40–70% isolieren. Die Triester werden durch Behandeln mit Zinkstaub in Nucleosid‐5′‐phosphate übergeführt.
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