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Article

The relation of various hypothalamic lesions to adiposity in the rat

A. W. Hetherington

Institute of Neurology, Northwestern University Medical School, Chicago, Illinois

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S. W. Ranson

Institute of Neurology, Northwestern University Medical School, Chicago, Illinois

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First published: June 1942
Cited by: 105

Aided by a grant from the Committee on Research in Endocrinology of the National Research Council.

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Number of times cited: 105

  • , An Emerging Technology Framework for the Neurobiology of Appetite, Cell Metabolism, 23, 2, (234), (2016).
  • , The elegance of energy balance: Insight from circuit‐level manipulations, Synapse, 69, 9, (461-474), (2015).
  • , The role of tanycytes in hypothalamic glucosensing, Journal of Cellular and Molecular Medicine, 19, 7, (1471-1482), (2015).
  • , Neuroanatomical association of hypothalamic HSD2-containing neurons with ERα, catecholamines, or oxytocin: implications for feeding?, Frontiers in Systems Neuroscience, 9, (2015).
  • , The hypothalamic neural–glial network and the metabolic syndrome, Best Practice & Research Clinical Endocrinology & Metabolism, 28, 5, (661), (2014).
  • , Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile, PLoS ONE, 9, 5, (e97195), (2014).
  • , Neuromodulation for Eating Disorders, Neurosurgery Clinics of North America, 25, 1, (147), (2014).
  • , Genetic aspects of human obesity, Clinical Neuroendocrinology, 10.1016/B978-0-444-59602-4.00006-X, (93-106), (2014).
  • , Resting‐state functional connectivity of the human hypothalamus, Human Brain Mapping, 35, 12, (6088-6096), (2014).
  • , Neuroendocrine Regulation of Energy Metabolism, Endocrinology and Metabolism, 27, 4, (268), (2012).
  • , Biology Without Walls: The Novel Endocrinology of Bone, Annual Review of Physiology, 10.1146/annurev-physiol-020911-153233, 74, 1, (87-105), (2012).
  • , Brainstem sensing of meal-related signals in energy homeostasis, Neuropharmacology, 10.1016/j.neuropharm.2012.03.019, 63, 1, (31-45), (2012).
  • , Towards a serotonin-dependent leptin roadmap in the brain, Trends in Endocrinology & Metabolism, 22, 9, (382), (2011).
  • , Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits, Cell Metabolism, 13, 4, (428), (2011).
  • , The role of NPY in hypothalamic mediated food intake, Frontiers in Neuroendocrinology, 32, 4, (398), (2011).
  • , Human hypothalamus shows differential responses to basic motivational stimuli—an invasive electrophysiology study, Neuroscience, 10.1016/j.neuroscience.2011.05.019, 189, (330-336), (2011).
  • , Central Nervous System Control of Nutrient Homeostasis, Comprehensive Physiology, (365-411), (2011).
  • , Glucose Sensing Neurons in the Ventromedial Hypothalamus, Sensors, 10, 12, (9002), (2010).
  • , Origins and Import of Reinforcing Self-Stimulation of the Brain, Journal of the History of the Neurosciences, 19, 1, (24), (2010).
  • , Unilateral neuromodulation of the ventromedial hypothalamus of the rat through deep brain stimulation, Journal of Neural Engineering, 7, 3, (036006), (2010).
  • , Hunger, Handbook of Neuroscience for the Behavioral Sciences, (2009).
  • , Feeding signals and brain circuitry, European Journal of Neuroscience, 30, 9, (1688-1696), (2009).
  • , Fuel utilization by hypothalamic neurons: roles for ROS, Trends in Endocrinology & Metabolism, 20, 2, (78), (2009).
  • , Insulin blunts the response of glucose-excited neurons in the ventrolateral-ventromedial hypothalamic nucleus to decreased glucose, American Journal of Physiology-Endocrinology and Metabolism, 296, 5, (E1101), (2009).
  • , Brain circuits regulating energy homeostasis, Regulatory Peptides, 149, 1-3, (3), (2008).
  • , Y eat?, Nutrition, 24, 9, (869), (2008).
  • , Neuronal control of energy homeostasis, FEBS Letters, 582, 1, (132-141), (2007).
  • , The Clockwork of Metabolism, Annual Review of Nutrition, 27, 1, (219), (2007).
  • , The unfolding cannabinoid story on energy homeostasis: central or peripheral site of action?, International Journal of Obesity, 30, S1, (S30), (2006).
  • , Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance, Neuron, 51, 6, (691), (2006).
  • , The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight, Physiology & Behavior, 87, 2, (221), (2006).
  • , The floating blueprint of hypothalamic feeding circuits, Nature Reviews Neuroscience, 5, 8, (662), (2004).
  • , Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284, 4, (R965), (2003).
  • , The skinny on neurotrophins, Nature Neuroscience, 6, 7, (655), (2003).
  • , Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor, Nature Neuroscience, 6, 7, (736), (2003).
  • , Effects of threonine injections in the lateral hypothalamus on intake of amino acid imbalanced diets in rats, Brain Research, 879, 1-2, (65), (2000).
  • , Chronic infusion of norepinephrine into the VMH of normal rats induces the obese glucose-intolerant state, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 278, 2, (R435), (2000).
  • , Brain regions where cholecystokinin suppresses feeding in rats, Brain Research, 860, 1-2, (1), (2000).
  • , Sex differences in body weight gains following amygdaloid lesions in rats, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 277, 4, (R975), (1999).
  • , The State of Research into the Mechanisms of Appetites for Energy (first published in French in 1956), Appetite, 33, 1, (2), (1999).
  • , Atlas of the neurons that express mRNA for the long form of the prolactin receptor in the forebrain of the female rat, Journal of Comparative Neurology, 386, 2, (161-177), (1998).
  • , Location of neurons that express regulated endocrine-specific protein-18 in the rat diencephalon, Neuroscience, 71, 2, (477), (1996).
  • , Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice, Developmental Dynamics, 204, 1, (22-29), (2005).
  • , Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris‐Leucoagglutinin study in the rat, Journal of Comparative Neurology, 348, 1, (41-79), (2004).
  • , Paraventricular hypothalamic obesity in rats: Role of corticosterone, Physiology & Behavior, 51, 6, (1207), (1992).
  • , Hypothalamic obesity: Comparison of radio-frequency and electrolytic lesions in weanling rats, Physiology & Behavior, 45, 1, (127), (1989).
  • , Comparison of radio-frequency and electrolytic lesions of the paraventricular hypothalamic nucleus, Physiology & Behavior, 46, 2, (321), (1989).
  • , Glucocorticoids and hypothalamic obesity, Neuroscience & Biobehavioral Reviews, 12, 1, (29), (1988).
  • , Effect of procaine injection into the ventromedial hypothalamic area (VMH) of the rat on serum insulin, glucose and corticosterone and gastric emptying rate, Physiology & Behavior, 43, 1, (29), (1988).
  • , Lesions in ventromedial hypothalamus or amygdala do not affect naloxone's suppression of water consumption, Physiology & Behavior, 36, 5, (967), (1986).
  • , THE ROLE OF THE MEDIAL HYPOTHALAMUS IN THE CONTROL OF FOOD INTAKE: AN UPDATE, Feeding Behavior Neural and Humoral Controls, 10.1016/B978-0-12-589060-1.50007-9, (27-66), (1986).
  • , Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats, Brain Research, 369, 1-2, (215), (1986).
  • , Nonirritative lesions of VMH: effects on plasma insulin, obesity, and hyperreactivity, American Journal of Physiology-Endocrinology and Metabolism, 248, 6, (E669), (1985).
  • , Influence of restricted food intake on brown adipose tissue function in genetically obese mice (genotype, ob/ob), Biochimica et Biophysica Acta (BBA) - General Subjects, 838, 2, (229), (1985).
  • , Food intake control in birds, Neuroscience & Biobehavioral Reviews, 9, 2, (223), (1985).
  • , Changes in food intake with electrical stimulation of the ventromedial hypothalamus in dogs, Journal of Neurosurgery, 60, 6, (1253), (1984).
  • , Diencephalic neuronal activity during acquisition and ingestion of food in sheep, Brain Research, 278, 1-2, (195), (1983).
  • , Effects of hypothalamic knife cuts on feeding induced by paraventricular norepinephrine injections, Pharmacology Biochemistry and Behavior, 16, 1, (101), (1982).
  • , Metabolic aspects of obesity, Molecular Aspects of Medicine, 5, 5, (293), (1982).
  • , Effects of adrenalectomy and corticosterone administration on hypothalamic obesity in rats, American Journal of Physiology-Endocrinology and Metabolism, 243, 2, (E152), (1982).
  • , The role of vagally-mediated hyperinsulinemia in hypothalamic obesity, Neuroscience & Biobehavioral Reviews, 6, 2, (205), (1982).
  • , Hypothalamic paraventricular nucleus lesions produce overeating and obesity in the rat, Physiology & Behavior, 27, 6, (1031), (1981).
  • , A re-examination of the ventromedial hypothalamic paradox, Neuroscience & Biobehavioral Reviews, 4, 2, (151), (1980).
  • , Hypothalamic obesity in female rats in absence of vagally mediated hyperinsulinemia, American Journal of Physiology-Endocrinology and Metabolism, 239, 6, (E437), (1980).
  • , Hypothalamic unit responses to alimentary perfusions in the anesthetised rat, Brain Research Bulletin, 4, 2, (259), (1979).
  • , Naloxone-induced suppression of food intake in normal and hypothalamic obese rats, Pharmacology Biochemistry and Behavior, 11, 6, (729), (1979).
  • , Some efferent connections of the rostral hypothalamus in the squirrel monkey (Saimiri sciureus) and cat, Journal of Comparative Neurology, 184, 2, (205-241), (2004).
  • , Amygdaloid and pontine projections to the ventromedial nucleus of the hypothalamus, The Journal of Comparative Neurology, 174, 3, (377), (1977).
  • , Reappearance of dynamic hyperphagia during the static phase in medial hypothalamic lesioned rats, Physiology & Behavior, 18, 5, (945), (1977).
  • , The pharmacology of anorexigenesis, Life Sciences, 21, 2, (173), (1977).
  • , Hyperphagia and hyperdipsia after locus coeruleus lesions in the stumptailed monkey, Life Sciences, 20, 9, (1619), (1977).
  • , The efferent connections of the ventromedial nucleus of the hypothalamus of the rat, , Journal of Comparative Neurology, 169, 4, (409-442), (2004).
  • , Organization of brainstem behavioral systems, Brain Research Bulletin, 1, 5, (471), (1976).
  • , The Dorsomedial Hypothalamic Nucleus In Autonomic And Neuroendocrine Homeostasis, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2, 01, (45), (1975).
  • , Reciprocal (push-pull) effects of morphine on single units in the ventromedian and lateral hypothalamus and influences on other nuclei: with a comment on methadone effects during withdrawal from morphine, Brain Research, 74, 1, (81), (1974).
  • , Evidence for ascending noradrenergic mediation of hypothalamic hyperphagia, Pharmacology Biochemistry and Behavior, 1, 1, (81), (1973).
  • , Hypothalamic Obesity: The Myth of the Ventromedial Nucleus, Science, 182, 4111, (488), (1973).
  • , The neurobiology of motivated behavior, Progress in Neurobiology, 1, (53), (1973).
  • , Obesity and increased growth following partial or complete isolation of ventromedial hypothalamus, Physiology & Behavior, 7, 2, (187), (1971).
  • , Participation of the dorsomedial hypothalamic nucleus in the “feeding center” and water intake circuitry of the weanling rat, Journal of Neuro-Visceral Relations, 31, 4, (387), (1970).
  • , Hyperphagia produced by knife cuts between the medial and lateral hypothalamus in the rat, Physiology & Behavior, 4, 4, (533), (1969).
  • , Relationship between amygdala and hypothalamus in the control of eating behavior, Physiology & Behavior, 4, 2, (199), (1969).
  • , FIBER DEGENERATION FOLLOWING LESIONS IN THE HYPOTHALAMIC VENTROMEDIAL NUCLEUS*, Annals of the New York Academy of Sciences, 157, 2, (610-628), (2006).
  • , Some properties of a lipid mobilizing substance from the calf mid-brain, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 176, 3, (511), (1969).
  • , SEX DIFFERENCES IN HYPERPHAGIA AND BODY WEIGHT FOLLOWING HYPOTHALAMIC DAMAGE*, Annals of the New York Academy of Sciences, 157, 2, (1030-1048), (2006).
  • , Alimentary responses to forebrain stimulation in monkeys, Experimental Brain Research, 4, 4, (330), (1968).
  • , Effect of ventromedial hypothalamic lesions on development of adrenal-regeneration hypertension in weanling female rats, Experientia, 23, 12, (1031), (1967).
  • , Effect of mesencephalic lesions on feeding behavior in rats, Experimental Neurology, 17, 3, (313), (1967).
  • , Untersuchungen über den Verzehrsrückgang bei proteinreicher Ernährung. 1. Mitteilung, Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde, 22, 1‐5, (141-160), (2009).
  • , The Periventricular Stratum of the Hypothalamus, International Review of Neurobiology Volume 9, 10.1016/S0074-7742(08)60140-3, (263-300), (1966).
  • , Failure to demonstrate a functional connection between the adrenal gland and ventromedial hypothalamic nuclei with regard to control of food intake, Experientia, 21, 1, (36), (1965).
  • , STUDIES OF THE VENTROMEDIAL HYPOTHALAMUS WITH AUTORADIOGRAPHIC TECHNIQUES*, Annals of the New York Academy of Sciences, 131, 1, (485-501), (2006).
  • , An electrophysiological study of the hypothalamic ventromedial nucleus in the cat, Electroencephalography and Clinical Neurophysiology, 15, 5, (786), (1963).
  • , The physiology of Vertebrate feeding behaviour: towards a synthesis of the ethological and physiological approaches to problems of behaviour, Zeitschrift für Tierpsychologie, 20, 4, (498-516), (2010).
  • , Food intake patterns from weaning to adulthood in male and female rats with hypothalamic lesions, Experientia, 19, 10, (541), (1963).
  • , A demonstration of a fall in brain serotonin following central nervous system lesions in the rat, Biochemical Pharmacology, 11, 9, (859), (1962).
  • , NEUROANATOMICAL STUDY OF OBESE AND NON-OBESE HYPOTHALAMIC MONKEYS IN RELATION TO FOOD INTAKE, LOCOMOTOR ACTIVITY, AND TEMPERATURE REGULATION, Canadian Journal of Biochemistry and Physiology, 40, 9, (1185), (1962).
  • , NEUROANATOMICAL STUDY OF OBESE AND NON-OBESE HYPOTHALAMIC MONKEYS IN RELATION TO FOOD INTAKE, LOCOMOTOR ACTIVITY, AND TEMPERATURE REGULATION, Canadian Journal of Biochemistry and Physiology, 40, 1, (1185), (1962).
  • , Hormones, Brain Function and Behavior, (99), (1957).
  • , THE EFFECTS OF RESERPINE ON EMOTIONAL BEHAVIOR OF NORMAL AND BRAIN‐OPERATED MONKEYS, Annals of the New York Academy of Sciences, 61, 1, (36-55), (2006).
  • , PRELIMINARY REPORT ON THE AMYGDALOIDECTOMY ON THE PSYCHOTIC PATIENTS, WITH INTERPRETATION OF ORAL‐EMOTIONAL MANIFESTATION IN SCHIZOPHRENICS, Psychiatry and Clinical Neurosciences, 7, 4, (309-329), (2008).
  • , The Relation of Obesity to Menstrual Disturbances, New England Journal of Medicine, 247, 2, (53), (1952).
  • , Effects of Hypothalamic Lesions on Water and Energy Metabolism in the Rat, Proceedings of the 1949 Laurentian Hormone Conference, 10.1016/B978-1-4831-9893-4.50016-2, (363-394), (1949).
  • , Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons, Nature Reviews Drug Discovery, 10.1038/nrd3739, 11, 9, (675-691), (2012)., (2012).
  • , The investigation of the effects of topiramate on the hypothalamic levels of fat mass/obesity-associated protein and neuropeptide Y in obese female rats, Nutritional Neuroscience, 10.1080/1028415X.2017.1374033, (1-10), (2017).