Short Paper
The half‐lives of serum immunoglobulins in adult mice
Abstract
We determined the half‐lives of several sets of murine monoclonal antibodies spanning all immunoglobulin isotypes in the serum. The antibodies in each set possess the same V region. With this approach, the differences in half‐life observed between the different isotypes are independent of the V region carried by the monoclonal antibodies and therefore must relate to each other in the same way as the half‐lives of each class of serum immunoglobulins.
The half‐life of a monoclonal antibody of the γ2a isotype is identical to the average half‐life of serum IgG2a, as previously determined (6‐8 days; P. Vieira and K. Rajewsky, Eur. J. Immunol. 1986. 16: 871). Therefore, the half‐lives determined with monoclonal antibodies possessing the same V region represent the half‐life of the serum immunoglobulins.
In this way we calculated the half‐life of IgM as 2 days, IgG3 and IgG1 as 6‐8 days, IgG2b has a half‐life of 4‐6 days. IgE has a half‐life of 12 h. A polymeric form of IgA was found to be eliminated from the serum with a half‐life of 17‐22 h.
Citing Literature
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