The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

Research Article

Cross‐adaptation of a model human stress‐related odour with fragrance chemicals and ethyl esters of axillary odorants: gender‐specific effects

Charles J. Wysocki

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Search for more papers by this author
Jennifer Louie

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA

Search for more papers by this author
James J. Leyden

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

Search for more papers by this author
David Blank

Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA

Current address: 11 Hetzel Road, Lebanon, New Hampshire (NH) 03766.Search for more papers by this author
Manjindar Gill

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA

Current address: 98 Chalfield Lane, Mississauga, Ontario L4Z 1L2, Canada.Search for more papers by this author
Les Smith

Fragrance Technology Development, Coty Inc., 410 American Road, Morris Plains, NJ 07950, USA

Search for more papers by this author
Keith McDermott

Symrise Inc., 300 North Street, Teterboro, NJ 07608, USA

Search for more papers by this author
George Preti

Corresponding Author

E-mail address:preti@monell.org

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
Search for more papers by this author
First published: 16 August 2009
Cited by: 10

Abstract

The human axillae have a characteristic odour that is comprised of or generated from a mixture of C6–C11 normal, branched, hydroxy‐ and unsaturated acids (and other compounds). We used ethyl esters of one of these acids and a palette of fragrance compounds (tested individually) to evaluate the effectiveness of these chemicals to reduce the overall olfactory impact of a model of human stress‐related odour (SRO) by cross‐adaptation (adaptation to one odorant can reduce sensitivity to other odorants). Sensory volunteers provided hedonic and intensity ratings of the SRO and of each of the potential cross‐adapting agents prior to 2.5 min of induced olfactory adaptation to each agent. Across adaptation, possible cross‐adaptation was evaluated by intermittent evaluations of the perceived intensity of the SRO. We determined that some potential cross‐adapting agents did reduce the impact of the SRO; however, the same chemicals were not necessarily effective for male and female SRO. Indeed, the list of effective chemicals depended upon the gender of the donor of the SRO and the gender of the sensory volunteer, suggesting a gender‐specific response to both the SRO‐stimuli used and the fragrance chemicals used to cross‐adapt it. Copyright © 2009 John Wiley & Sons, Ltd.

Number of times cited: 10

  • , Rapid Stress System Drives Chemical Transfer of Fear from Sender to Receiver, PLOS ONE, 10, 2, (e0118211), (2015).
  • , Enhanced Chemosensory Detection of Negative Emotions in Congenital Blindness, Neural Plasticity, 10.1155/2015/469750, 2015, (1-7), (2015).
  • , Ethnic/Racial and Genetic Influences on Cerumen Odorant Profiles, Journal of Chemical Ecology, 10.1007/s10886-014-0533-y, 41, 1, (67-74), (2014).
  • , Differentiation of Complex Vapor Mixtures Using Versatile DNA–Carbon Nanotube Chemical Sensor Arrays, ACS Nano, 7, 3, (2800), (2013).
  • , Human Gender Differences in the Perception of Conspecific Alarm Chemosensory Cues, PLoS ONE, 8, 7, (e68485), (2013).
  • , Chemosignals Communicate Human Emotions, Psychological Science, 23, 11, (1417), (2012).
  • , Pheromonal Regulation of Male Sexuality, Hormonal Therapy for Male Sexual Dysfunction, (11-27), (2011).
  • , Human Olfactory Perception, The Chemistry and Biology of Volatiles, (253-289), (2010).
  • , 2-Nonenal-Ovulatory Specific Volatiles in Human Saliva throughout Menstrual Cycle by Gas Chromatography and Mass Spectrometry Analysis, American Journal of Biochemistry and Biotechnology, 6, 3, (187), (2010).
  • , Essential oil research: past, present and future, Flavour and Fragrance Journal, 25, 3, (112-113), (2010).