Research Article
Focused ultrasound modulates the level of cortical neurotransmitters: Potential as a new functional brain mapping technique*
*
This work was partially supported by Center for Integration of Medicine and Innovation (CIMIT to Yoo), Saint Mary's Hospital (to Yang), and the National Research Foundation grant funded by the Korea government (MEST) (2010‐0027294 to Park)
Abstract
Regional modulation of the level of cortical neurotransmitters in the brain would serve as a new functional brain mapping technique to interrogate the neurochemical actions of the brain. We investigated the utility of the application of low‐intensity, pulsed sonication of focused ultrasound (FUS) to the brain to modulate the extracellular level of dopamine (DA) and serotonin (5‐HT). FUS was delivered to the thalamic areas of rats, and extracellular DA and 5‐HT were sampled from the frontal lobe using the microdialysis technique. The concentration changes of the sampled DA and 5‐HT were measured through high‐performance liquid chromatography. We observed a significant increase of the extracellular concentrations of DA and 5‐HT in the FUS‐treated group as compared with those in the unsonicated group. Our results provide the first direct evidence that FUS sonication alters the level of extracellular concentration of these monoamine neurotransmitters and has a potential modulatory effect on their local release, uptake, or degradation. Our findings suggest that the pulsed application of FUS offers new perspectives for a possible noninvasive modulation of neurotransmitters and may have diagnostic as well as therapeutic implications for DA/5‐HT‐mediated neurological and psychiatric disorders. © 2011 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 21, 232–240, 2011
Citing Literature
Number of times cited: 29
- Seung‐Schik Yoo, Kyungho Yoon, Phillip Croce, Amanda Cammalleri, Ryan W. Margolin and Wonhye Lee, Focused ultrasound brain stimulation to anesthetized rats induces long‐term changes in somatosensory evoked potentials, International Journal of Imaging Systems and Technology, 28, 2, (106-112), (2017).
- Hongchae Baek, Ki Joo Pahk and Hyungmin Kim, A review of low-intensity focused ultrasound for neuromodulation, Biomedical Engineering Letters, 10.1007/s13534-016-0007-y, 7, 2, (135-142), (2017).
- Evgenii Kim, Eloise Anguluan and Jae Gwan Kim, Monitoring cerebral hemodynamic change during transcranial ultrasound stimulation using optical intrinsic signal imaging, Scientific Reports, 10.1038/s41598-017-13572-0, 7, 1, (2017).
- Christopher J. Wright, Seyyed R. Haqshenas, John Rothwell and Nader Saffari, Unmyelinated Peripheral Nerves Can Be Stimulated in Vitro Using Pulsed Ultrasound, Ultrasound in Medicine & Biology, 10.1016/j.ultrasmedbio.2017.05.008, 43, 10, (2269-2283), (2017).
- Charissa Poon, Dallan McMahon and Kullervo Hynynen, Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound, Neuropharmacology, 10.1016/j.neuropharm.2016.02.014, 120, (20-37), (2017).
- A. Kelly, L. Ballerini, M. Lowery and M. Biggs, 7.32 Engineering the Neural Interface, Comprehensive Biomaterials II, 10.1016/B978-0-12-803581-8.09322-X, (642-660), (2017).
- Omer Naor, Steve Krupa and Shy Shoham, Ultrasonic neuromodulation, Journal of Neural Engineering, 10.1088/1741-2560/13/3/031003, 13, 3, (031003), (2016).
- Wonhye Lee, Stephanie D. Lee, Michael Y. Park, Lori Foley, Erin Purcell-Estabrook, Hyungmin Kim, Krisztina Fischer, Lee-So Maeng and Seung-Schik Yoo, Image-Guided Focused Ultrasound-Mediated Regional Brain Stimulation in Sheep, Ultrasound in Medicine & Biology, 10.1016/j.ultrasmedbio.2015.10.001, 42, 2, (459-470), (2016).
- Seung-Schik Yoo, Wonhye Lee and Ferenc A. Jolesz, FUS-Mediated Image-Guided Neuromodulation of the Brain, Neurophotonics and Brain Mapping, 10.1201/9781315373058-24, (443-455), (2017).
- Wonhye Lee, Hyun-Chul Kim, Yujin Jung, Yong An Chung, In-Uk Song, Jong-Hwan Lee and Seung-Schik Yoo, Transcranial focused ultrasound stimulation of human primary visual cortex, Scientific Reports, 10.1038/srep34026, 6, 1, (2016).
- Ivan Mauricio Suarez Castellanos, Bogdan Balteanu, Tania Singh and Vesna Zderic, Therapeutic Modulation of Calcium Dynamics Using Ultrasound and Other Energy-Based Techniques, IEEE Reviews in Biomedical Engineering, 10.1109/RBME.2016.2555760, 9, (177-191), (2016).
- A. Bystritsky and A. S. Korb, A Review of Low-Intensity Transcranial Focused Ultrasound for Clinical Applications, Current Behavioral Neuroscience Reports, 10.1007/s40473-015-0039-0, 2, 2, (60-66), (2015).
- Wonhye Lee, Hyungmin Kim, Yujin Jung, In-Uk Song, Yong An Chung and Seung-Schik Yoo, Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex, Scientific Reports, 10.1038/srep08743, 5, 1, (2015).
- C J Wright, J Rothwell and N Saffari, Ultrasonic stimulation of peripheral nervous tissue: an investigation into mechanisms, Journal of Physics: Conference Series, 10.1088/1742-6596/581/1/012003, 581, (012003), (2015).
- Eduardo J. Juan, Rafael González, Gabriel Albors, Matthew P. Ward and Pedro Irazoqui, Vagus nerve modulation using focused pulsed ultrasound: Potential applications and preliminary observations in a rat, International Journal of Imaging Systems and Technology, 24, 1, (67-71), (2014).
- Wonhye Lee, Hyungmin Kim, Sungon Lee, Seung‐Schik Yoo and Yong An Chung, Creation of various skin sensations using pulsed focused ultrasound: Evidence for functional neuromodulation, International Journal of Imaging Systems and Technology, 24, 2, (167-174), (2014).
- Wonhye Lee, Stephanie D. Lee, Michael Y. Park, Jaechun Yang and Seung‐Schik Yoo, Evaluation of polyvinyl alcohol cryogel as an acoustic coupling medium for low‐intensity transcranial focused ultrasound, International Journal of Imaging Systems and Technology, 24, 4, (332-338), (2014).
- Tiffany Scarcelli, Jessica F. Jordão, Meaghan A. O'Reilly, Nicholas Ellens, Kullervo Hynynen and Isabelle Aubert, Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice, Brain Stimulation, 10.1016/j.brs.2013.12.012, 7, 2, (304-307), (2014).
- Ronald Bauer, Ernst Martin, Stefan Haegele-Link, Georg Kaegi, Moritz von Specht and Beat Werner, Noninvasive functional neurosurgery using transcranial MR imaging-guided focused ultrasound, Parkinsonism & Related Disorders, 10.1016/S1353-8020(13)70046-4, 20, (S197-S199), (2014).
- Hyungmin Kim, Alan Chiu, Stephanie D. Lee, Krisztina Fischer and Seung-Schik Yoo, Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters, Brain Stimulation, 10.1016/j.brs.2014.06.011, 7, 5, (748-756), (2014).
- Hyungmin Kim, Mi‐Ae Park, Shuyan Wang, Alan Chiu, Krisztina Fischer and Seung‐Schik Yoo, PET/CT imaging evidence of FUS‐mediated (18)F‐FDG uptake changes in rat brain, Medical Physics, 40, 3, (2013). 2013 International Winter Workshop on Brain-Computer Interface (BCI) Gangwon Province, Korea (South) 2013 International Winter Workshop on Brain-Computer Interface (BCI) IEEE , (2013). 978-1-4673-5974-0 978-1-4673-5973-3 Byoung-Kyong Min Eeg/sonication-based brain-brain interfacing , (2013). 19 20 6506614 , 10.1109/IWW-BCI.2013.6506614 http://ieeexplore.ieee.org/document/6506614/
- Ernst Martin and Beat Werner, Focused Ultrasound Surgery of the Brain, Current Radiology Reports, 10.1007/s40134-013-0013-0, 1, 2, (126-135), (2013).
- Hyungmin Kim, Alan Chiu, Shinsuk Park and Seung‐Schik Yoo, Image‐guided navigation of single‐element focused ultrasound transducer, International Journal of Imaging Systems and Technology, 22, 3, (177-184), (2012).
- Hyungmin Kim, Seyed Javid Taghados, Krisztina Fischer, Lee-So Maeng, Shinsuk Park and Seung-Schik Yoo, Noninvasive Transcranial Stimulation of Rat Abducens Nerve by Focused Ultrasound, Ultrasound in Medicine & Biology, 10.1016/j.ultrasmedbio.2012.04.023, 38, 9, (1568-1575), (2012).
- L. R. Gavrilov and E. M. Tsirulnikov, Focused ultrasound as a tool to input sensory information to humans (Review), Acoustical Physics, 10.1134/S1063771012010083, 58, 1, (1-21), (2012).
- Po Song Yang, Hyungmin Kim, Wonhye Lee, Mark Bohlke, Shinsuk Park, Timothy J. Maher and Seung-Schik Yoo, Transcranial Focused Ultrasound to the Thalamus Is Associated with Reduced Extracellular GABA Levels in Rats, Neuropsychobiology, 10.1159/000336001, 65, 3, (153-160), (2012).
- Seung-Schik Yoo, Hyungmin Kim, Byoung-Kyong Min, Eric Franck and Shinsuk Park, Transcranial focused ultrasound to the thalamus alters anesthesia time in rats, NeuroReport, 10.1097/WNR.0b013e32834b2957, 22, 15, (783-787), (2011).
- Seung-Schik Yoo, Hyungmin Kim, Emmanuel Filandrianos, Seyed Javid Taghados, Shinsuk Park and Julie A. Chowen, Non-Invasive Brain-to-Brain Interface (BBI): Establishing Functional Links between Two Brains, PLoS ONE, 10.1371/journal.pone.0060410, 8, 4, (e60410), (2013).
