Nucleoside, IV1) Über die Tritylierung und Benzylierung von Adenosin‐Derivaten
Abstract
deDie Tritylierung von Adenosin (1) und N6‐Benzoyl‐adenosin (2) mit wechselnder Menge Tritylchlorid wird beschrieben. Es werden neben Mono‐ und Di‐ auch Tritrityl‐Derivate isoliert und charakterisiert. Der Trityl‐Rest wird als wertvolle Schutzgruppe für die Aminfunktion des Adenosins erkannt. Benzylierungen N6‐blockierter Adenosine finden bei Anwendung der NaH‐Methode selektiv an den Hydroxylgruppen des Ribose‐Restes statt.
Abstract
enNucleosides, IV1) Tritylation and Benzylation of Adenosine Derivatives
Tritylation and benzylation of adenosine (1) and N6‐benzoyl‐adenosine (2) is described. Mono‐, di‐ and tritrityl derivatives have been isolated in pure form and have been characterized by physical methods. The trityl group has been recognized as a suitable blocking group for the 6‐amino group of adenosine derivatives. N6‐blocked adenosines will benzylate selectively at the hydroxyl groups of the ribose moiety.
Number of times cited: 17
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