The regulation of jejunal induction of the maltase–glucoamylase gene by a high‐starch/low‐fat diet in mice
Abstract
Maltase and glucoamylase are derived from the same mRNA and are responsible for digestion of starch in the small intestine. Their jejunal activities in rodents are induced by a high‐starch/low‐fat (HS)‐diet. However, it is unknown whether jejunal expression of the maltase–glucoamylase (Mgam) gene is enhanced by the HS‐diet. In this study, we found that jejunal Mgam mRNA was increased by a HS‐diet in mice. We showed that the HS‐diet increased acetylation of histones, bindings of a coactivator, Creb binding protein (CREBBP), and the transcriptional factors caudal type homeobox 2 (CDX2) and HNF1 homeobox (HNF1) in the promoter/enhancer and transcriptional regions of Mgam gene. This suggests that the increase in the jejunal activity of maltase and glucoamylase caused by a HS‐diet in mice is regulated at the mRNA level through histone acetylation and binding of CREBBP, CDX2 and HNF1 in the promoter/enhancer and transcriptional regions of Mgam gene.
Number of times cited: 14
- Catalina I. Fernández and Andrea S. Wiley, Rethinking the starch digestion hypothesis for AMY1 copy number variation in humans, American Journal of Physical Anthropology, 163, 4, (645-657), (2017).
- Meric Simsek, Roberto Quezada-Calvillo, Buford L. Nichols and Bruce R. Hamaker, Phenolic compounds increase the transcription of mouse intestinal maltase-glucoamylase and sucrase-isomaltase, Food Funct., 8, 5, (1915), (2017).
- C. Gatica‐Sosa, P. Brzęk, J. G. Chediack, F. D. Cid, W. H. Karasov and E. Caviedes‐Vidal, Differential transcriptional responses underlie dietary induction of intestinal carbohydrase activities in house sparrow nestlings, Journal of Animal Physiology and Animal Nutrition, 100, 2, (236-242), (2015).
- Yuko Inamochi, Anup Dey, Akira Nishiyama, Takeo Kubota, Keiko Ozato, Toshinao Goda and Kazuki Mochizuki, Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression, Biochemistry and Biophysics Reports, 7, (150), (2016).
- Aki Yamada, Kazue Honma, Kazuki Mochizuki and Toshinao Goda, BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver, Metabolism, 65, 10, (1478), (2016).
- Amy Hui-Mei Lin, Byung-Hoo Lee and Wei-Jen Chang, Small intestine mucosal α-glucosidase: A missing feature of in vitro starch digestibility, Food Hydrocolloids, 53, (163), (2016).
- Genyi Zhang, Like Y. Hasek, Byung-Hoo Lee and Bruce R. Hamaker, Gut feedback mechanisms and food intake: a physiological approach to slow carbohydrate bioavailability, Food & Function, 6, 4, (1072), (2015).
- Kazue HONMA, Kazuki MOCHIZUKI and Toshinao GODA, Induction by Fructose Force-Feeding of Histone H3 and H4 Acetylation at Their Lysine Residues around theSlc2a5Gene and Its Expression in Mice, Bioscience, Biotechnology, and Biochemistry, 77, 11, (2188), (2013).
- Masaya Shimada, Kazuki Mochizuki and Toshinao Goda, Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch, The Journal of Nutritional Biochemistry, 24, 3, (606), (2013).
- Erik Axelsson, Abhirami Ratnakumar, Maja-Louise Arendt, Khurram Maqbool, Matthew T. Webster, Michele Perloski, Olof Liberg, Jon M. Arnemo, Åke Hedhammar and Kerstin Lindblad-Toh, The genomic signature of dog domestication reveals adaptation to a starch-rich diet, Nature, 495, 7441, (360), (2013).
- Veronique Douard, Takuji Suzuki, Yves Sabbagh, Jacklyn Lee, Sue Shapses, Sheldon Lin and Ronaldo P. Ferraris, Dietary fructose inhibits lactation-induced adaptations in rat 1,25-(OH)2D3 synthesis and calcium transport, The FASEB Journal, 26, 2, (707), (2012).
- M. Denise Robertson, Dietary-resistant starch and glucose metabolism, Current Opinion in Clinical Nutrition and Metabolic Care, 15, 4, (362), (2012).
- William H. Karasov, Carlos Martínez del Rio and Enrique Caviedes-Vidal, Ecological Physiology of Diet and Digestive Systems, Annual Review of Physiology, 73, 1, (69), (2011).
- Brent L. Williams, Mady Hornig, Timothy Buie, Margaret L. Bauman, Myunghee Cho Paik, Ivan Wick, Ashlee Bennett, Omar Jabado, David L. Hirschberg, W. Ian Lipkin and Steven Jacobson, Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances, PLoS ONE, 6, 9, (e24585), (2011).
