Magnetic resonance elastography of brain: Comparison between anisotropic and isotropic stiffness and its correlation to age

Abstract

Purpose

Noninvasive measurement of mechanical properties of brain tissue using magnetic resonance elastography (MRE) has been a promising method for investigating neurologic disorders such as multiple sclerosis, hydrocephalus, and Alzheimer’s. However, because of the regional and directional dependency of brain stiffness, estimating anisotropic stiffness is important. This study investigates isotropic and anisotropic stiffness as a function of age as well as the correlation between isotropic and anisotropic stiffness.

Methods

MRE and diffusion tensor imaging (DTI) were performed on 28 healthy subjects with age ranges between 18–62 y. Isotropic and anisotropic stiffness was measured and compared with age for different regions of interest such as the thalamus, corpus callosum, gray matter, white matter, and whole brain.

Results

Isotropic stiffness in gray matter (r_s = −0.57; P = 0.001) showed a significant decrease with age. Anisotropic stiffness in gray matter showed a significant decrease with age in C₁₁ through C₆₆ and in the thalamus, only in C₃₃. Between anisotropic and isotropic stiffness, gray matter showed a significant positive correlation in C₁₁ through C₆₆, C₂₂ and C₆₆ showed a significant negative correlation in the thalamus and whole brain, and C₄₄ showed a negative correlation in the corpus callosum. No significant difference between genders was observed in any measurements.

Conclusion

This study demonstrated a change in isotropic and anisotropic stiffness with age in different regions of the brain along with a correlation of anisotropic stiffness to isotropic stiffness.