Research Article
Tutorial in biostatistics: competing risks and multi‐state models
Abstract
Standard survival data measure the time span from some time origin until the occurrence of one type of event. If several types of events occur, a model describing progression to each of these competing risks is needed. Multi‐state models generalize competing risks models by also describing transitions to intermediate events. Methods to analyze such models have been developed over the last two decades. Fortunately, most of the analyzes can be performed within the standard statistical packages, but may require some extra effort with respect to data preparation and programming. This tutorial aims to review statistical methods for the analysis of competing risks and multi‐state models. Although some conceptual issues are covered, the emphasis is on practical issues like data preparation, estimation of the effect of covariates, and estimation of cumulative incidence functions and state and transition probabilities. Examples of analysis with standard software are shown. Copyright © 2006 John Wiley & Sons, Ltd.
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- Heinz Freisling, Vivian Viallon, Hannah Lennon, Vincenzo Bagnardi, Cristian Ricci, Adam S. Butterworth, Michael Sweeting, David Muller, Isabelle Romieu, Pauline Bazelle, Marina Kvaskoff, Patrick Arveux, Gianluca Severi, Christina Bamia, Tilman Kühn, Rudolf Kaaks, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Anja Olsen, Kim Overvad, Christina C. Dahm, Virginia Menéndez, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Carmen Santiuste, Aurelio Barricarte Gurrea, Tammy Y. N. Tong, Julie A. Schmidt, Ioanna Tzoulaki, Konstantinos K. Tsilidis, Heather Ward, Domenico Palli, Claudia Agnoli, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, H. Susan J. Picavet, Marije Bakker, Evelyn Monninkhof, Peter Nilsson, Jonas Manjer, Olov Rolandsson, Elin Thysell, Elisabete Weiderpass, Mazda Jenab, Elio Riboli, Paolo Vineis, John Danesh, Nick J. Wareham, Marc J. Gunter, Pietro Ferrari, Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study, BMC Medicine, 10.1186/s12916-019-1474-7, 18, 1, (2020).
- Aditi Nayak, Tiffany Dong, Yi‐An Ko, Neile Chesnut, Ann Pekarek, Robert T. Cole, Kunal Bhatt, Divya Gupta, Michael A. Burke, S. Raja Laskar, Tamer Attia, Andrew L. Smith, J. David Vega, Alanna A. Morris, Validating patient prioritization in the 2018 Revised United Network for Organ Sharing Heart Allocation System: A single‐center experience, Clinical Transplantation, 10.1111/ctr.13816, 34, 3, (2020).
- Lisa Van den Bosch, Ewoud Schuit, Hans Paul van der Laan, Johannes B. Reitsma, Karel G.M. Moons, Roel J.H.M. Steenbakkers, Frank J.P. Hoebers, Johannes A. Langendijk, Arjen van der Schaaf, Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy, Radiotherapy and Oncology, 10.1016/j.radonc.2020.04.012, (2020).
- Rasmus Østergaard Nielsen, Ian Shrier, Martí Casals, Alberto Nettel-Aguirre, Merete Møller, Caroline Bolling, Nataliá F.N. Bittencourt, Ben Clarsen, Niels Wedderkopp, Torbjørn Soligard, Toomas Timpka, Carolyn A. Emery, Roald Bahr, Jenny Jacobsson, Rod Whiteley, Örjan Dahlström, Nicol van Dyk, Babette M. Pluim, Emmanuel Stamatakis, Luz Palacios-Derflingher, Morten W. Fagerland, Karim M. Khan, Clare L. Ardern, Evert Verhagen, Statement on Methods in Sport Injury Research From the First METHODS MATTER Meeting, Copenhagen, 2019, Journal of Orthopaedic & Sports Physical Therapy, 10.2519/jospt.2020.9876, 50, 5, (226-233), (2020).
- Xiaolin Chen, Yahui Zhang, Yi Liu, Xiaojing Chen, Model-free feature screening for ultra-high dimensional competing risks data, Statistics & Probability Letters, 10.1016/j.spl.2020.108815, 164, (108815), (2020).
- Sheharyar Raza, Deva Thiruchelvam, Donald A. Redelmeier, Death and long-term disability after gun injury: a cohort analysis, CMAJ Open, 10.9778/cmajo.20190200, 8, 3, (E469-E478), (2020).
- Eduardo Vilar-Gomez, Luis Calzadilla-Bertot, Vincent Wai-Sun Wong, Marlen Castellanos, Rocio Aller-de la Fuente, Mohammed Eslam, Grace Lai-Hung Wong, Jacob George, Manuel Romero-Gomez, Leon A. Adams, Type 2 Diabetes and Metformin Use Associate With Outcomes of Patients With Nonalcoholic Steatohepatitis–Related, Child–Pugh A Cirrhosis, Clinical Gastroenterology and Hepatology, 10.1016/j.cgh.2020.04.083, (2020).
- Michiel C.T. van Zeijl, John B.A.G. Haanen, Michel W.J.M. Wouters, Liesbeth C. de Wreede, Anouk Jochems, Maureen J.B. Aarts, Franchette W.P.J. van den Berkmortel, Jan Willem B. de Groot, Geke A.P. Hospers, Ellen W. Kapiteijn, Djura Piersma, Rozemarijn S. van Rijn, Karijn P.M. Suijkerbuijk, Albert J. ten Tije, Astrid A.M. van der Veldt, Gerard Vreugdenhil, Koos J.M. van der Hoeven, Alfons J.M. van den Eertwegh, Real-world Outcomes of First-line Anti-PD-1 Therapy for Advanced Melanoma: A Nationwide Population-based Study, Journal of Immunotherapy, 10.1097/CJI.0000000000000334, 43, 8, (256), (2020).
- P.T.J. Sanders, J.F. Spierings, J.I. Albergo, M.P.A. Bus, M. Fiocco, G.L. Farfalli, M.A.J. van de Sande, L.A. Aponte-Tinao, P.D.S. Dijkstra, Long-Term Clinical Outcomes of Intercalary Allograft Reconstruction for Lower-Extremity Bone Tumors, Journal of Bone and Joint Surgery, 10.2106/JBJS.18.00893, 102, 12, (1042-1049), (2020).
- C.W.P.G. van der Wal, F.E. Eggermont, M. Fiocco, H.M. Kroon, O. Ayu, A. Slot, A. Snyers, T. Rozema, N.J.J. Verdonschot, P.D.S. Dijkstra, E.J. Tanck, Y.M. van der Linden, Axial cortical involvement of metastatic lesions to identify impending femoral fractures; a clinical validation study, Radiotherapy and Oncology, 10.1016/j.radonc.2019.10.007, 144, (59-64), (2020).
- Rafiqul I. Chowdhury, Mohammed Ataharul Islam, Regressive models for risk prediction of repeated multinomial outcomes: An illustration using Health and Retirement Study data, Biometrical Journal, 10.1002/bimj.201800101, 62, 4, (898-915), (2020).
- Jesse Sussell, Alison R. Silverstein, Prodyumna Goutam, Devin Incerti, Rebecca Kee, Corinna X. Chen, Donald S. Batty, Jeroen P. Jansen, Bertram L. Kasiske, The economic burden of kidney graft failure in the United States, American Journal of Transplantation, 10.1111/ajt.15750, 20, 5, (1323-1333), (2020).
- Svetlana I. Nihtyanova, Alper Sari, Jennifer C. Harvey, Anna Leslie, Emma C. Derrett‐Smith, Carmen Fonseca, Voon H. Ong, Christopher P. Denton, Using Autoantibodies and Cutaneous Subset to Develop Outcome‐Based Disease Classification in Systemic Sclerosis, Arthritis & Rheumatology, 10.1002/art.41153, 72, 3, (465-476), (2020).
- Sarit Agami, David M. Zucker, Donna Spiegelman, Estimation in the Cox survival regression model with covariate measurement error and a changepoint, Biometrical Journal, 10.1002/bimj.201800085, 62, 5, (1139-1163), (2020).
- Esther Bastiaannet, Research Methods: Epidemiologic Research in Geriatric Oncology, Geriatric Oncology, 10.1007/978-3-319-57415-8, (1031-1042), (2020).
- Sahar Nouri, Mahmood Mahmoudi, Kazem Mohammad, Mohammad Ali Mansournia, Mahdi Yaseri, Noori Akhtar-Danesh, Methods of competing risks flexible parametric modeling for estimation of the risk of the first disease among HIV infected men, BMC Medical Research Methodology, 10.1186/s12874-020-0900-z, 20, 1, (2020).
- Valentijn M.T. Jong, Karel G.M. Moons, Richard D. Riley, Catrin Tudur Smith, Anthony G. Marson, Marinus J.C. Eijkemans, Thomas P.A. Debray, Individual participant data meta‐analysis of intervention studies with time‐to‐event outcomes: A review of the methodology and an applied example, Research Synthesis Methods, 10.1002/jrsm.1384, 11, 2, (148-168), (2020).
- Ismail Baydur, Toshihiko Mukoyama, Job duration and match characteristics over the business cycle, Review of Economic Dynamics, 10.1016/j.red.2020.01.003, (2020).
- Xiang‐Lin Tan, Jian‐Yu E, Yong Lin, Timothy R. Rebbeck, Shou‐En Lu, Mingyi Shang, William K. Kelly, Anthony D'Amico, Mark N. Stein, Lanjing Zhang, Thomas L. Jang, Isaac Yi Kim, Kitaw Demissie, Anna Ferrari, Grace Lu‐Yao, Individual and joint effects of metformin and statins on mortality among patients with high‐risk prostate cancer, Cancer Medicine, 10.1002/cam4.2862, 9, 7, (2379-2389), (2020).
- O. F. Dent, J. E. Ripley, C. Chan, M. J. F. X. Rickard, A. Keshava, P. Stewart, P. H. Chapuis, Competing risks analysis of the association between perioperative blood transfusion and long‐term outcomes after resection of colorectal cancer, Colorectal Disease, 10.1111/codi.14970, 22, 8, (871-884), (2020).
- Amin Keramati, Pan Lu, Denver Tolliver, Xingju Wang, Geometric effect analysis of highway-rail grade crossing safety performance, Accident Analysis & Prevention, 10.1016/j.aap.2020.105470, 138, (105470), (2020).
- Saber Dini, Nicholas M. Douglas, Jeanne Rini Poespoprodjo, Enny Kenangalem, Paulus Sugiarto, Ian D. Plumb, Ric N. Price, Julie A. Simpson, The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study, BMC Medicine, 10.1186/s12916-020-1497-0, 18, 1, (2020).
- Aneth V Kalinjuma, Tracy R Glass, Maja Weisser, Selarine J Myeya, Bryson Kasuga, Yassin Kisung'a, George Sikalengo, Andrew Katende, Manuel Battegay, Fiona Vanobberghen, Aschola Asantiel, Farida Bani, Manuel Battegay, Theonestina Byakuzana, Adolphina Chale, Anna Eichenberger, Sauli J Epimack, Gideon Francis, Hansjakob Furrer, Anna Gamell, Tracy R Glass, Speciosa Hwaya, Bryson Kasuga, Namvua Kimera, Andrew Katende, Yassin Kisunga, Aneth V Kalinjuma, Thomas Klimkait, Emilio Letang, Ezekiel Luoga, Lameck B Luwanda, Herry Mapesi, Ngisi P Masawa, Mengi Mkulila, Julius Mkumbo, Margareth Mkusa, Dorcas K Mnzava, Gertrud J Mollel, Germana Mossad, Lilian Moshi, Dolores Mpundunga, Athumani Mtandanguo, Selerine Myeya, Sanula Nahota, Regina Ndaki, Robert C Ndege, Agatha Ngulukila, Alex J Ntamatungiro, Amina Nyuri, Daniel H Paris, Omary N Rajab, Leila Samson, George Sikalengo, Fiona Vanobberghen, Maja Weisser, John Wigay, Prospective assessment of loss to follow‐up: incidence and associated factors in a cohort of HIV‐positive adults in rural Tanzania, Journal of the International AIDS Society, 10.1002/jia2.25460, 23, 3, (2020).
- Hein Putter, Martin Schumacher, Hans C. van Houwelingen, On the relation between the cause‐specific hazard and the subdistribution rate for competing risks data: The Fine–Gray model revisited, Biometrical Journal, 10.1002/bimj.201800274, 62, 3, (790-807), (2020).
- Aaron N. Winn, Nicole M. Fergestrom, Liliana E. Pezzin, Purushottam W. Laud, Joan M. Neuner, The impact of generic aromatase inhibitors on initiation, adherence, and persistence among women with breast cancer: Applying multi‐state models to understand the dynamics of adherence, Pharmacoepidemiology and Drug Safety, 10.1002/pds.4995, 29, 5, (550-557), (2020).
- Mateusz Jobczyk, Konrad Stawiski, Wojciech Fendler, Waldemar Różański, Validation of EORTC, CUETO, and EAU risk stratification in prediction of recurrence, progression, and death of patients with initially non–muscle‐invasive bladder cancer (NMIBC): A cohort analysis, Cancer Medicine, 10.1002/cam4.3007, 9, 11, (4014-4025), (2020).
- Clifford O. Odimegwu, Emmanuel O. Olamijuwon, Vesper H. Chisumpa, Joshua O. Akinyemi, Mwiza G. Singini, Oluwaseyi D. Somefun, How soon do single mothers have another child? A competing risk analysis of second premarital childbearing in sub-Saharan African countries, BMC Pregnancy and Childbirth, 10.1186/s12884-020-2850-1, 20, 1, (2020).
- Noah A. Schuster, Emiel O. Hoogendijk, Almar A.L. Kok, Jos W.R. Twisk, Martijn W. Heymans, Ignoring competing events in the analysis of survival data may lead to biased results: a nonmathematical illustration of competing risk analysis, Journal of Clinical Epidemiology, 10.1016/j.jclinepi.2020.03.004, 122, (42-48), (2020).
- Alice Schneider, Stefan Blüher, Ulrike Grittner, Verena Anton, Elke Schaeffner, Natalie Ebert, Olga Jakob, Peter Martus, Adelheid Kuhlmey, Volker Wenning, Susanne Schnitzer, Is there an association between social determinants and care dependency risk? A multi‐state model analysis of a longitudinal study, Research in Nursing & Health, 10.1002/nur.22022, 43, 3, (230-240), (2020).
- Neda Stjepanovic, Guillermo Villacampa, Kevin T. Nead, Sara Torres-Esquius, Guadalupe G. Melis, Katherine L. Nathanson, Alexandre Teule, Joan Brunet, Teresa R. y Cajal, Gemma Llort, Rodrigo Dienstmann, Montserrat Rue, Susan M. Domchek, Judith Balmaña, Association of premenopausal risk-reducing salpingo-oophorectomy with breast cancer risk in BRCA1/2 mutation carriers: Maximising bias-reduction, European Journal of Cancer, 10.1016/j.ejca.2020.03.009, 132, (53-60), (2020).
- Haiping Lin, Hongjuan Zheng, Chenyang Ge, Qinghua Wang, Wanfen Tang, Xia Zhang, Shishi Zhou, Xiayun Jin, Xifeng Xu, Jinlin Du, Jianfei Fu, The effect of adjuvant treatment in small node-negative HER2-positive breast cancer: which subgroup will benefit?, Clinical Breast Cancer, 10.1016/j.clbc.2020.05.012, (2020).
- Ying Shang, Laura Fratiglioni, Anna Marseglia, Anna Plym, Anna‐Karin Welmer, Hui‐Xin Wang, Rui Wang, Weili Xu, Association of diabetes with stroke and post‐stroke dementia: A population‐based cohort study, Alzheimer's & Dementia, 10.1002/alz.12101, 16, 7, (1003-1012), (2020).
- Francesca Gasperoni, Francesca Ieva, Anna Maria Paganoni, Christopher H Jackson, Linda Sharples, Evaluating the effect of healthcare providers on the clinical path of heart failure patients through a semi-Markov, multi-state model, BMC Health Services Research, 10.1186/s12913-020-05294-3, 20, 1, (2020).
- Zelalem G. Dessie, Temesgen Zewotir, Henry Mwambi, Delia North, Modelling HIV disease process and progression in seroconversion among South Africa women: using transition-specific parametric multi-state model, Theoretical Biology and Medical Modelling, 10.1186/s12976-020-00128-5, 17, 1, (2020).
- Pim B van der Meer, Linda Dirven, Marta Fiocco, Martin JB Taphoorn, Johan AF Koekkoek, Retention rates of antiepileptic drugs in glioma patients: the most appropriate outcome, CNS Oncology, 10.2217/cns-2020-0009, 9, 2, (CNS53), (2020).
- Azra Ramezankhani, Michael J. Blaha, Mohammad hassan Mirbolouk, Fereidoun Azizi, Farzad Hadaegh, Multi-state analysis of hypertension and mortality: application of semi-Markov model in a longitudinal cohort study, BMC Cardiovascular Disorders, 10.1186/s12872-020-01599-7, 20, 1, (2020).
- Shalender Bhasin, Thomas M. Gill, David B. Reuben, Nancy K. Latham, David A. Ganz, Erich J. Greene, James Dziura, Shehzad Basaria, Jerry H. Gurwitz, Patricia C. Dykes, Siobhan McMahon, Thomas W. Storer, Priscilla Gazarian, Michael E. Miller, Thomas G. Travison, Denise Esserman, Martha B. Carnie, Lori Goehring, Maureen Fagan, Susan L. Greenspan, Neil Alexander, Jocelyn Wiggins, Fred Ko, Albert L. Siu, Elena Volpi, Albert W. Wu, Jeremy Rich, Stephen C. Waring, Robert B. Wallace, Carri Casteel, Neil M. Resnick, Jay Magaziner, Peter Charpentier, Charles Lu, Katy Araujo, Haseena Rajeevan, Can Meng, Heather Allore, Brooke F. Brawley, Rich Eder, Joanne M. McGloin, Eleni A. Skokos, Pamela W. Duncan, Dorothy Baker, Chad Boult, Rosaly Correa-de-Araujo, Peter Peduzzi, A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries, New England Journal of Medicine, 10.1056/NEJMoa2002183, 383, 2, (129-140), (2020).
- Amin Keramati, Pan Lu, Amirfarrokh Iranitalab, Danguang Pan, Ying Huang, A crash severity analysis at highway-rail grade crossings: The random survival forest method, Accident Analysis & Prevention, 10.1016/j.aap.2020.105683, 144, (105683), (2020).
- Rinku Sutradhar, Lisa Barbera, Multistate models for examining the progression of intermittently-measured patient-reported symptoms among cancer patients: the importance of accounting for interval censoring, Journal of Pain and Symptom Management, 10.1016/j.jpainsymman.2020.07.012, (2020).
- Francesco Cottone, Gary S. Collins, Amelie Anota, Kathrin Sommer, Johannes M. Giesinger, Jacobien M. Kieffer, Neil K. Aaronson, Kristel Van Steen, Emilie Charton, Fausto Castagnetti, Paola Fazi, Marco Vignetti, David Cella, Fabio Efficace, Time to health-related quality of life improvement analysis was developed to enhance evaluation of modern anticancer therapies, Journal of Clinical Epidemiology, 10.1016/j.jclinepi.2020.06.016, 127, (9-18), (2020).
- Amin Keramati, Pan Lu, Xiaoyi Zhou, Denver Tolliver, A Simultaneous Safety Analysis of Crash Frequency and Severity for Highway-Rail Grade Crossings: The Competing Risks Method, Journal of Advanced Transportation, 10.1155/2020/8878911, 2020, (1-13), (2020).
- Chongkai Wang, Dawnyel Chevalier, Janelle Saluja, Jaideep Sandhu, Cecilia Lau, Marwan Fakih, Regorafenib and Nivolumab or Pembrolizumab Combination and Circulating Tumor DNA Response Assessment in Refractory Microsatellite Stable Colorectal Cancer, The Oncologist, 10.1634/theoncologist.2020-0161, 25, 8, (e1188-e1194), (2020).
- Vinaya Dulipati, Seppo Meri, Jaana Panelius, Complement evasion strategies of Borrelia burgdorferi sensu lato, FEBS Letters, 10.1002/1873-3468.13894, 594, 16, (2645-2656), (2020).
- Erin E. Collins, John S. Hargrove, Thomas A. Delomas, Shawn R. Narum, Distribution of genetic variation underlying adult migration timing in steelhead of the Columbia River basin, Ecology and Evolution, 10.1002/ece3.6641, 10, 17, (9486-9502), (2020).
- Sebastian F. Winter, Eugene J. Vaios, Alona Muzikansky, Maria Martinez‐Lage, Marc R. Bussière, Helen A. Shih, Jay Loeffler, Philipp Karschnia, Franziska Loebel, Peter Vajkoczy, Jorg Dietrich, Defining Treatment‐Related Adverse Effects in Patients with Glioma: Distinctive Features of Pseudoprogression and Treatment‐Induced Necrosis, The Oncologist, 10.1634/theoncologist.2020-0085, 25, 8, (e1221-e1232), (2020).
- Ching‐Yao Yang, Wei‐Yu Liao, Chao‐Chi Ho, Kuan‐Yu Chen, Tzu‐Hsiu Tsai, Chia‐Lin Hsu, Yi‐Nan Liu, Kang‐Yi Su, Yih‐Leong Chang, Chen‐Tu Wu, Bin‐Chi Liao, Chia‐Chi Hsu, Wei‐Hsun Hsu, Jih‐Hsiang Lee, Chia‐Chi Lin, Jin‐Yuan Shih, James Chih‐Hsin Yang, Chong‐Jen Yu, Association of Programmed Death‐Ligand 1 Expression with Fusion Variants and Clinical Outcomes in Patients with Anaplastic Lymphoma Kinase‐Positive Lung Adenocarcinoma Receiving Crizotinib, The Oncologist, 10.1634/theoncologist.2020-0088, 25, 8, (702-711), (2020).
- Saber Boutayeb, Ibrahim El Ghissassi, Hind Mrabti, Hassan Errihani, How to Manage Febrile Neutropenia During the COVID Pandemic?, The Oncologist, 10.1634/theoncologist.2020-0285, 25, 8, (e1251-e1251), (2020).
- Yuxiang Ma, Wenfeng Fang, Yang Zhang, Yunpeng Yang, Shaodong Hong, Yuanyuan Zhao, Shuang Xie, Jun Ge, HaoJin Zhou, Hongyun Zhao, Li Zhang, KEYNOTE‐032: A Randomized Phase I Study of Pembrolizumab in Chinese Patients with Advanced Non‐Small Cell Lung Cancer, The Oncologist, 10.1634/theoncologist.2020-0067, 25, 8, (650-e1145), (2020).
- Koichi Takayama, Masafumi Takeshita, Koji Inoue, Masao Ichiki, Masaki Fujita, Taishi Harada, Yoshimasa Shiraishi, Hiroshi Wataya, Shoji Tokunaga, Tadaaki Yamada, Junji Uchino, Kenji Sugio, Randomized Phase II Study of First‐Line Biweekly Gemcitabine and Carboplatin Versus Biweekly Gemcitabine and Carboplatin plus Maintenance Gemcitabine in Elderly Patients with Untreated Non‐Small Cell Lung Cancer: LOGIK0801, The Oncologist, 10.1634/theoncologist.2020-0322, 25, 8, (e1146-e1157), (2020).
- Enrique Grande, Javier Molina‐Cerrillo, Teresa Alonso‐Gordoa, In Reply, The Oncologist, 10.1634/theoncologist.2020-0336, 25, 8, (e1259-e1259), (2020).
- Franck Courchamp, Philip E Hulme, Petr Pyšek, Invasion biology and uncertainty in native range definitions: response to Pereyra 2019, Conservation Biology, 10.1111/cobi.13528, 34, 4, (1041-1043), (2020).
- Patricio Javier Pereyra, Radu Cornel Guiaşu, Debate over the importance and meaning of native range in invasion biology: reply to Courchamp et al. , Conservation Biology, 10.1111/cobi.13529, 34, 4, (1044-1046), (2020).
- William J. Sutherland, Sergio Ticul Alvarez‐Castañeda, Tatsuya Amano, Roberto Ambrosini, Philip Atkinson, John M. Baxter, Alexander L. Bond, Philip J. Boon, Katherine L. Buchanan, Jos Barlow, Giuseppe Bogliani, Olivia M. Bragg, Mark Burgman, Marc W. Cadotte, Michael Calver, Steven J. Cooke, Richard T. Corlett, Vincent Devictor, John G. Ewen, Martin Fisher, Guy Freeman, Edward Game, Brendan J. Godley, Christian Gortázar, Ian R. Hartley, David L. Hawksworth, Keith A. Hobson, Ming‐Lun Lu, Berta Martín‐López, Keping Ma, Antonio Machado, Dirk Maes, Marco Mangiacotti, Dominic J. McCafferty, Victoria Melfi, Sanjay Molur, Allen J. Moore, Stephen D. Murphy, Darren Norris, Alexander P.E. Oudenhoven, Jennifer Powers, Eileen C. Rees, Mark W. Schwartz, Ilse Storch, Claire Wordley, Ensuring tests of conservation interventions build on existing literature, Conservation Biology, 10.1111/cobi.13555, 34, 4, (781-783), (2020).
- Robert Wesolowski, Daniel G. Stover, Maryam B. Lustberg, Abigail Shoben, Meng Zhao, Ewa Mrozek, Rachel M. Layman, Erin Macrae, Wenrui Duan, Jun Zhang, Nathan Hall, Chadwick L. Wright, Susan Gillespie, Michael Berger, Jeffrey J. Chalmers, Alahdra Carey, Priya Balasubramanian, Brandon L. Miller, Peter Amaya, Eleni Andreopoulou, Joseph Sparano, Charles L. Shapiro, Miguel Angel Villalona‐Calero, Susan Geyer, Alice Chen, Michael R. Grever, Michael V. Knopp, Bhuvaneswari Ramaswamy, Phase I Study of Veliparib on an Intermittent and Continuous Schedule in Combination with Carboplatin in Metastatic Breast Cancer: A Safety and [18F]‐Fluorothymidine Positron Emission Tomography Biomarker Study, The Oncologist, 10.1634/theoncologist.2020-0039, 25, 8, (e1158-e1169), (2020).
- Inbar Raber, Mary Linton Peters, Aarti Asnani, In Reply, The Oncologist, 10.1634/theoncologist.2020-0119, 25, 8, (e1255-e1256), (2020).
- William S. Lynn, Francisco J. Santiago‐Ávila, John Hadidian, Arian D. Wallach, Joann Lindenmayer, Misunderstandings of science and ethics in the moral panic over cats: reply to Crespin et al. 2020, Conservation Biology, 10.1111/cobi.13527, 34, 4, (1038-1040), (2020).
- Marta Scorsetti, Karyn A. Goodman, Jinsil Seong, Mauro Loi, Florence Huguet, Laura A. Dawson, Hepatocellular Carcinoma in the COVID‐19 Era: Primetime for Stereotactic Body Radiotherapy and a Lesson for the Future?, The Oncologist, 10.1634/theoncologist.2020-0416, 25, 8, (e1249-e1250), (2020).
- Matthieu Schmidt, David Hajage, Guillaume Lebreton, Antoine Monsel, Guillaume Voiriot, David Levy, Elodie Baron, Alexandra Beurton, Juliette Chommeloux, Paris Meng, Safaa Nemlaghi, Pierre Bay, Pascal Leprince, Alexandre Demoule, Bertrand Guidet, Jean Michel Constantin, Muriel Fartoukh, Martin Dres, Alain Combes, Charles-Edouard Luyt, Guillaume Hekimian, Nicolas Brechot, Marc Pineton de Chambrun, Cyrielle Desnos, Jeremy Arzoine, Emmanuelle Guerin, Thibaut Schoell, Pierre Demondion, Charles Juvin, Nathalie Nardonne, Sofica Marin, Cossimo D'Alessandro, Bao-Long Nguyen, Cyril Quemeneur, Arthur James, Mona Assefi, Victoria Lepere, Guillaume Savary, Aude Gibelin, Matthieu Turpin, Alexandre Elabbadi, Enora Berti, Corinne Vezinet, Harold Bonvallot, Pierre-Romain Delmotte, Martin De Sarcus, Charlotte Du Fayet De La Tour, Samia Abbas, Eric Maury, Jean-Luc Baudel, Jean-Remi Lavillegrand, Hafid Ait Oufella, Abdelmalek Abdelkrim, Thomas Urbina, Sara Virolle, Robin Deleris, Vincent Bonny, Julien Le Marec, Julien Mayaux, Elise Morawiec, Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study, The Lancet Respiratory Medicine, 10.1016/S2213-2600(20)30328-3, (2020).
- San-Gang Wu, Jian Shi, Wen-Wen Zhang, Jun Wang, Chen-Lu Lian, Jian Lei, Li Hua, Juan Zhou, Zhen-Yu He, Prognostic validation and treatment decision making of the 8th edition of the American Joint Committee on Cancer pathological staging system for elderly women with early-stage breast cancer, Aging, 10.18632/aging.103574, 12, 14, (15077-15090), (2020).
- Francisco J. Santiago-Ávila, Richard J. Chappell, Adrian Treves, Liberalizing the killing of endangered wolves was associated with more disappearances of collared individuals in Wisconsin, USA, Scientific Reports, 10.1038/s41598-020-70837-x, 10, 1, (2020).
- Francesca Pierri, Chrys Caroni, Analysing the Risk of Bankruptcy of Firms: Survival Analysis, Competing Risks and Multistate Models, Demography of Population Health, Aging and Health Expenditures, 10.1007/978-3-030-44695-6_25, (385-394), (2020).
- Noorie Hyun, Hormuzd A. Katki, Barry I. Graubard, Sample‐weighted semiparametric estimation of cause‐specific cumulative risk and incidence using left‐ or interval‐censored data from electronic health records, Statistics in Medicine, 10.1002/sim.8544, 39, 18, (2387-2402), (2020).
- Barbara Riegel, Alisa Stephens‐Shields, Anne Jaskowiak‐Barr, Marguerite Daus, Stephen E. Kimmel, A behavioral economics‐based telehealth intervention to improve aspirin adherence following hospitalization for acute coronary syndrome, Pharmacoepidemiology and Drug Safety, 10.1002/pds.4988, 29, 5, (513-517), (2020).
- L. Schmidt Sørensen, S. Ladefoged Rasmussen, P. C. Calder, M. Nytoft Yilmaz, E. Berg Schmidt, O. Thorlacius‐Ussing, Long‐term outcomes after perioperative treatment with omega‐3 fatty acid supplements in colorectal cancer, BJS Open, 10.1002/bjs5.50295, 4, 4, (678-684), (2020).
- Shams‐Ul Mahmood, Yasir Nazir, Aamer Saeed, Qamar Abbas, Zaman Ashraf, Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Coumarinylthiazolyl Iminothiazolidinone Hybrids as Potent Urease Inhibitors, ChemistrySelect, 10.1002/slct.202000429, 5, 18, (5387-5390), (2020).
- Piero Presenti, Mattia Moiola, Paolo Quadrelli, 5‐Hydroxy‐isoxazolidine: A New Synthetic Approach to a Privileged Heterocycle for Organic Synthesis, ChemistrySelect, 10.1002/slct.202001337, 5, 18, (5367-5373), (2020).
- Akram Saad, Jeffrey Goldstein, Ofer Margalit, Einat Shacham‐Shmueli, Yaacov R. Lawrence, Yu‐Xiao Yang, Kim A. Reiss, Talia Golan, Ronac Mamtani, Naama Halpern, Dan Aderka, Meir Mouallem, Adam Goldstein, Bruce Giantonio, Ben Boursi, Assessing the effects of beta‐blockers on pancreatic cancer risk: A nested case‐control study, Pharmacoepidemiology and Drug Safety, 10.1002/pds.4993, 29, 5, (599-604), (2020).
- Kerryn W. Reding, Aaron K. Aragaki, Richard K. Cheng, Ana Barac, Sylvia Wassertheil‐Smoller, Jessica Chubak, Marian C. Limacher, W. Gregory Hundley, Ralph D'Agostino, Mara Z. Vitolins, Theodore M. Brasky, Laurel A. Habel, Eric J. Chow, Rebecca D. Jackson, Chu Chen, April Morgenroth, Wendy E. Barrington, Matthew Banegas, Matthew Barnhart, Rowan T. Chlebowski, Cardiovascular Outcomes in Relation to Antihypertensive Medication Use in Women with and Without Cancer: Results from the Women's Health Initiative, The Oncologist, 10.1634/theoncologist.2019-0977, 25, 8, (712-721), (2020).
- Yanfang Liu, Hsin-An Hou, Hong Qiu, Chao-Hsiun Tang, Is the risk of second primary malignancy increased in multiple myeloma in the novel therapy era? A population-based, retrospective cohort study in Taiwan, Scientific Reports, 10.1038/s41598-020-71243-z, 10, 1, (2020).
- Jasper Grashuis, Jason Franken, Exit strategies of farmer co-operatives in the United States: A competing risks analysis, Journal of Co-operative Organization and Management, 10.1016/j.jcom.2020.100119, 8, 2, (100119), (2020).
- Max P.L. van der Sijp, Monica van Eijk, Arthur H.P. Niggebrugge, Hein Putter, Gerard J. Blauw, Wilco P. Achterberg, Prognostic Factors for Short-term Recovery of Independence in a Multistate Model for Patients With a Hip Fracture, Journal of the American Medical Directors Association, 10.1016/j.jamda.2020.08.006, (2020).
- Guofeng Li, Guangsuo Wang, Yanhua Guo, Shixuan Li, Youlong Zhang, Jialu Li, Bin Peng, Development of a novel prognostic score combining clinicopathologic variables, gene expression, and mutation profiles for lung adenocarcinoma, World Journal of Surgical Oncology, 10.1186/s12957-020-02025-0, 18, 1, (2020).
- Ronald B. Geskus, Competing risks: Aims and methods, , 10.1016/bs.host.2019.11.001, (2020).
- Somayeh Momenyan, Jalal Poorolajal, Modeling of spatio-temporally clustered survival HIV/AIDS data in the presence of competing risks setting, Spatial Statistics, 10.1016/j.spasta.2020.100460, 38, (100460), (2020).
- Tobias Mütze, Tim Friede, Data monitoring committees for clinical trials evaluating treatments of COVID-19, Contemporary Clinical Trials, 10.1016/j.cct.2020.106154, 98, (106154), (2020).
- M. Overgaard, State Occupation Probabilities in Non-Markov Models, Mathematical Methods of Statistics, 10.3103/S1066530719040033, 28, 4, (279-290), (2020).
- Jin-Lan Liao, Yu-Hui Zhang, Zi-Bo Xiong, Li Hao, Gui-Ling Liu, Ye-Ping Ren, Qin Wang, Li-Ping Duan, Zhao-Xia Zheng, Zu-Ying Xiong, Jie Dong, The Association of Cognitive Impairment with Peritoneal Dialysis-Related Peritonitis, Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 10.3747/pdi.2018.00180, 39, 3, (229-235), (2020).
- Noemi Pavo, Raphael Wurm, Stephanie Neuhold, Christopher Adlbrecht, Greisa Vila, Guido Strunk, Martin Clodi, Michael Resl, Helmut Brath, Rudolf Prager, Anton Luger, Richard Pacher, Martin Hülsmann, GDF-15 Is Associated with Cancer Incidence in Patients with Type 2 Diabetes, Clinical Chemistry, 10.1373/clinchem.2016.257212, 62, 12, (1612-1620), (2020).
- Ye In Jane Hwang, Olayan Albalawi, Armita Adily, Malcolm Hudson, Handan Wand, Azar Kariminia, Colman O’Driscoll, Stephen Allnutt, Luke Grant, Grant Sara, James Ogloff, David Mace Greenberg, Tony Butler, Disengagement from mental health treatment and re-offending in those with psychosis: a multi-state model of linked data, Social Psychiatry and Psychiatric Epidemiology, 10.1007/s00127-020-01873-1, (2020).
- Danilo Alvares, Carmen Armero, Anabel Forte, Nicolas Chopin, Sequential Monte Carlo methods in Bayesian joint models for longitudinal and time-to-event data, Statistical Modelling, 10.1177/1471082X20916088, (1471082X2091608), (2020).
- M. Krogsgaard, I. Gögenur, F. Helgstrand, R. M. Andersen, A. K. Danielsen, A. Vinther, T. W. Klausen, J. Hillingsø, B. M. Christensen, T. Thomsen, Surgical repair of parastomal bulging: a retrospective register‐based study on prospectively collected data, Colorectal Disease, 10.1111/codi.15197, 0, 0, (2020).
- Hyunsoon Cho, Dahhay Lee, Sanghee Lee, Sangbum Choi, Applications of competing risks analysis in public health, Journal of the Korean Statistical Society, 10.1007/s42952-020-00058-5, (2020).
- Matthieu Frasca, Angeline Galvin, Chantal Raherison, Pierre Soubeyran, Benoît Burucoa, Carine Bellera, Simone Mathoulin-Pelissier, Palliative versus hospice care in patients with cancer: a systematic review, BMJ Supportive & Palliative Care, 10.1136/bmjspcare-2020-002195, (bmjspcare-2020-002195), (2020).
- Monique K. van der Kooij, Marjolein J.A.L. Wetzels, Maureen J.B. Aarts, Franchette W.P.J. van den Berkmortel, Christian U. Blank, Marye J. Boers-Sonderen, Miranda P. Dierselhuis, Jan Willem B. de Groot, Geke A.P. Hospers, Djura Piersma, Rozemarijn S. van Rijn, Karijn P.M. Suijkerbuijk, Albert J. ten Tije, Astrid A.M. van der Veldt, Gerard Vreugdenhil, Michel W.J.M. Wouters, John B.A.G. Haanen, Alfonsus J.M. van den Eertwegh, Esther Bastiaannet, Ellen Kapiteijn, Age Does Matter in Adolescents and Young Adults versus Older Adults with Advanced Melanoma; A National Cohort Study Comparing Tumor Characteristics, Treatment Pattern, Toxicity and Response, Cancers, 10.3390/cancers12082072, 12, 8, (2072), (2020).
- Mark Thackham, Jun Ma, On maximum likelihood estimation of competing risks using the cause-specific semi-parametric Cox model with time-varying covariates – An application to credit risk, Journal of the Operational Research Society, 10.1080/01605682.2020.1800418, (1-10), (2020).
- Gaofeng Gu, Tao Feng, Dujuan Yang, Harry Timmermans, Modeling dynamics in household car ownership over life courses: a latent class competing risks model, Transportation, 10.1007/s11116-019-10078-8, (2020).
- Jose-Ramon Blanco, Belen Alejos, Santiago Moreno, Immune recovery markers in a double blind clinical trial comparing dolutegravir and raltegravir based regimens as initial therapy (SPRING-2), PLOS ONE, 10.1371/journal.pone.0226724, 15, 1, (e0226724), (2020).
- Pintao Lyu, Anja De Waegenaere, Bertrand Melenberg, A Multi-population Approach to Forecasting All-Cause Mortality Using Cause-of-Death Mortality Data, North American Actuarial Journal, 10.1080/10920277.2019.1662316, (1-36), (2020).
- Giorgos Bakoyannis, Ying Zhang, Constantin T. Yiannoutsos, Semiparametric regression and risk prediction with competing risks data under missing cause of failure, Lifetime Data Analysis, 10.1007/s10985-020-09494-1, (2020).
- Mário de Castro, Ming‐Hui Chen, Yuanye Zhang, Anthony V. D'Amico, A Bayesian multi‐risks survival (MRS) model in the presence of double censorings, Biometrics, 10.1111/biom.13228, 0, 0, (2020).
- Cristina Mosconi, Annagiulia Gramenzi, Maurizio Biselli, Alberta Cappelli, Antonio Bruno, Caterina De Benedittis, Alessandro Cucchetti, Francesco Modestino, Giuliano Peta, Giampaolo Bianchi, Franco Trevisani, Rita Golfieri, Survival and Tolerability of Transarterial Chemoembolization in Greater Versus less than 70 Years of Age Patients with Unresectable Hepatocellular Carcinoma: A Propensity Score Analysis, CardioVascular and Interventional Radiology, 10.1007/s00270-020-02451-3, (2020).
- Gurdeep S Mannu, Zhe Wang, John Broggio, Jackie Charman, Shan Cheung, Olive Kearins, David Dodwell, Sarah C Darby, Invasive breast cancer and breast cancer mortality after ductal carcinoma in situ in women attending for breast screening in England, 1988-2014: population based observational cohort study, BMJ, 10.1136/bmj.m1570, (m1570), (2020).
- Mayu Hosio, Elina Urpilainen, Ari Hautakoski, Mikko Marttila, Martti Arffman, Reijo Sund, Anne Ahtikoski, Ulla Puistola, Peeter Karihtala, Arja Jukkola, Esa Läärä, Survival after breast cancer in women with type 2 diabetes using antidiabetic medication and statins: a retrospective cohort study, Acta Oncologica, 10.1080/0284186X.2020.1769858, (1-8), (2020).
- Philani B. Mpofu, Giorgos Bakoyannis, Constantin T. Yiannoutsos, Ann W. Mwangi, Margaret Mburu, A pseudo‐likelihood method for estimating misclassification probabilities in competing‐risks settings when true‐event data are partially observed, Biometrical Journal, 10.1002/bimj.201900198, 0, 0, (2020).
- Ina Jazić, Stephanie Lee, Sebastien Haneuse, Estimation and inference for semi-competing risks based on data from a nested case-control study, Statistical Methods in Medical Research, 10.1177/0962280220926219, (096228022092621), (2020).
- Richard Chamboko, Jorge Miguel Bravo, A Multi-State Approach to Modelling Intermediate Events and Multiple Mortgage Loan Outcomes, Risks, 10.3390/risks8020064, 8, 2, (64), (2020).
- Angela Dispenzieri, D. R. Larson, S. V. Rajkumar, R. A. Kyle, S. K. Kumar, Taxiarchis Kourelis, Bonnie Arendt, Maria Willrcih, Surendra Dasari, David Murray, N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor for MGUS progression, Leukemia, 10.1038/s41375-020-0940-8, (2020).
- Ala Abudayyeh, Heather Lin, Maen Abdelrahim, Gabriela Rondon, Borje S. Andersson, Charles S. Martinez, Valda D. Page, Jeffrey J. Tarrand, Dimitrios P. Kontoyiannis, David Marin, Betul Oran, Amanda Olson, Roy Jones, Uday Popat, Richard E. Champlin, Roy F. Chemaly, Elizabeth J. Shpall, Katayoun Rezvani, Development and validation of a risk assessment tool for BKPyV Replication in allogeneic stem cell transplant recipients, Transplant Infectious Disease, 10.1111/tid.13395, 0, 0, (2020).
- Jacqueline E. Rudolph, Catherine R. Lesko, Ashley I. Naimi, Causal Inference in the Face of Competing Events, Current Epidemiology Reports, 10.1007/s40471-020-00240-7, (2020).
- Thoralf Lange, Christian Niederwieser, Arthur Gil, Rainer Krahl, Ulrich von Grünhagen, Haifa Kathrin Al-Ali, Kathleen Jentsch-Ullrich, Claudia Spohn, Volker Lakner, Michael Assmann, Christian Junghanss, Michael Cross, Rüdiger Hehlmann, Michael Deininger, Markus Pfirrmann, Dietger Niederwieser, No advantage of Imatinib in combination with hydroxyurea over Imatinib monotherapy: a study of the East German Study Group (OSHO) and the German CML study group, Leukemia & Lymphoma, 10.1080/10428194.2020.1786556, (1-10), (2020).
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