Volume 27, Issue 26
Research Article

Bayesian bootstrap estimation of ROC curve

Jiezhun Gu

Corresponding Author

E-mail address: jiezhun.gu@duke.edu

Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, U.S.A.

Duke Clinical Research Institute, Duke University Medical Center, P.O. Box 17969, Durham, NC 27715, U.S.A.Search for more papers by this author
Subhashis Ghosal

Department of Statistics, North Carolina State University, Raleigh, NC, U.S.A.

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Anindya Roy

Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, MD, U.S.A.

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First published: 09 July 2008
Citations: 32

Abstract

Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes the ROC analysis one of the most active research areas in medical statistics. Many parametric and semiparametric estimation methods have been proposed for estimating the ROC curve and its functionals. In this paper, we propose the Bayesian bootstrap (BB), a fully nonparametric estimation method, for the ROC curve and its functionals, such as the area under the curve (AUC). The BB method offers a bandwidth‐free smoothing approach to the empirical estimate, and gives credible bounds. The accuracy of the estimate of the ROC curve in the simulation studies is examined by the integrated absolute error. In comparison with other existing curve estimation methods, the BB method performs well in terms of accuracy, robustness and simplicity. We also propose a procedure based on the BB approach to test the binormality assumption. Copyright © 2008 John Wiley & Sons, Ltd.

Number of times cited according to CrossRef: 32

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