Volume 35, Issue 7
Special Issue Paper

Comparisons of the performance of different statistical tests for time‐to‐event analysis with confounding factors: practical illustrations in kidney transplantation

Florent Le Borgne

SPHERE (EA 4275): bioStatistics, Pharmacoepidemiology & Human sciEnces REsearch, University of Nantes, Nantes, France

IDBC/A2com, Espace Antrium Parc de la Teillais, 35740 PACE France

Transplantation, Urology and Nephrology Institute (ITUN), Nantes Hospital and University, Nantes, INSERM U1064 France

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Bruno Giraudeau

Centre de recherche Epidémiologie et Biostatistique, INSERM U1153, Paris, France

Centre d'Investigation clinique INSERM, Tours, CIC 1415 France

Université François Rabelais de Tours, PRES Centre‐Val de Loire Université, Tours, France

CHRU de Tours, Tours, France

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Anne Héléne Querard

SPHERE (EA 4275): bioStatistics, Pharmacoepidemiology & Human sciEnces REsearch, University of Nantes, Nantes, France

Transplantation, Urology and Nephrology Institute (ITUN), Nantes Hospital and University, Nantes, INSERM U1064 France

Médecine néphrologie ‐ Hémodialyse, Centre Hospitalier Départemental Vendée Site de La Roche sur Yon, France

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Magali Giral

Transplantation, Urology and Nephrology Institute (ITUN), Nantes Hospital and University, Nantes, INSERM U1064 France

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Yohann Foucher

Corresponding Author

SPHERE (EA 4275): bioStatistics, Pharmacoepidemiology & Human sciEnces REsearch, University of Nantes, Nantes, France

Transplantation, Urology and Nephrology Institute (ITUN), Nantes Hospital and University, Nantes, INSERM U1064 France

Correspondence to: Yohann Foucher, SPHERE (EA 4275): bioStatistics, Pharmacoepidemiology & Human sciEnces REsearch, University of Nantes, Nantes, France.

E‐mail: Yohann.Foucher@univ‐nantes.fr

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First published: 29 October 2015
Citations: 15

Abstract

Confounding factors are commonly encountered in observational studies. Several confounder‐adjusted tests to compare survival between differently exposed subjects were proposed. However, only few studies have compared their performances regarding type I error rates, and no study exists evaluating their type II error rates. In this paper, we performed a comparative simulation study based on two different applications in kidney transplantation research. Our results showed that the propensity score‐based inverse probability weighting (IPW) log‐rank test proposed by Xie and Liu (2005) can be recommended as a first descriptive approach as it provides adjusted survival curves and has acceptable type I and II error rates. Even better performance was observed for the Wald test of the parameter corresponding to the exposure variable in a multivariable‐adjusted Cox model. This last result is of primary interest regarding the exponentially increasing use of propensity score‐based methods in the literature. Copyright © 2015 John Wiley & Sons, Ltd.

Number of times cited according to CrossRef: 15

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