Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis
Abstract
Objective
Obsessive–compulsive disorder (OCD ) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS ) have been implicated. The present study aims to systematically review the literature for quantitative evidence that patients with OCD have altered measures of blood O&NS markers.
Methods
Independent random‐effects meta‐analyses using standardized mean differences were conducted to assess each marker separately. Additionally, data from multiple markers were pooled together in a meta‐analysis for measures of oxidant activity and another for measures of antioxidant activity.
Results
Thirteen studies met inclusion criteria, involving 433 OCD patients and 459 controls. Eleven blood O&NS markers were eligible for independent quantitative analyses. We found that, in OCD patients, the oxidant markers 8‐hydroxydeoxyguanosine and malondialdehyde, and the antioxidants glutathione peroxidase and superoxide dismutase, were significantly increased while total antioxidant status, vitamin C, and vitamin E were significantly decreased, when comparing with controls. Regarding pooled meta‐analyses, we found a statistically significant increase in oxidant markers, but non‐significant results regarding antioxidant markers.
Conclusions
Our meta‐analysis suggests that OCD patients have a systemic oxidative imbalance that is not adequately buffered by the antioxidant system. Additional studies are needed in order to support this association.
Citing Literature
Number of times cited according to CrossRef: 7
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- A. H. Mohammadi, E. Balandeh, A. Milajerdi, Reanalysis is needed for the ‘Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis’, Acta Psychiatrica Scandinavica, 10.1111/acps.13124, 141, 1, (88-88), (2019).
- Xing Huang, Jinjuan Zhang, Jie Liu, Xinhua Zhang, Association study of the PDE4D gene and obsessive-compulsive disorder in a Chinese Han population, Psychiatric Genetics, 10.1097/YPG.0000000000000236, 29, 6, (226-231), (2019).
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- Larisa A. Savelieva, Andrei A. Andreev, Raphael Gromig, Dmitry A. Subetto, Grigory B. Fedorov, Volker Wennrich, Bernd Wagner, Martin Melles, Vegetation and climate changes in northwestern Russia during the Lateglacial and Holocene inferred from the Lake Ladoga pollen record, Boreas, 10.1111/bor.12376, 48, 2, (349-360), (2019).
- Zhen-Ye Zhang, Ling-Feng Miao, Ling-Ling Qian, Ning Wang, Miao-Miao Qi, Yu-Min Zhang, Shi-Peng Dang, Ying Wu, Ru-Xing Wang, Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications, Frontiers in Endocrinology, 10.3389/fendo.2019.00640, 10, (2019).
