Volume 72, Issue 3
BIOMETRIC METHODOLOGY

Sparse estimation of Cox proportional hazards models via approximated information criteria

Xiaogang Su

Corresponding Author

E-mail address: xsu@utep.edu

Department of Mathematical Sciences, University of Texas, El Paso, Texas, U.S.A.

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Chalani S. Wijayasinghe

Department of Mathematical Sciences, University of Texas, El Paso, Texas, U.S.A.

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Juanjuan Fan

Department of Mathematics and Statistics, San Diego State University, San Diego, California, U.S.A.

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Ying Zhang

Department of Biostatistics, Indiana University Fairbanks School of Public Health and School of Medicine, Indianapolis, Indiana, U.S.A.

Department of Statistics, Shanghai Jiao Tong University, Shanghai, China

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First published: 12 February 2016
Citations: 9

Summary

We propose a new sparse estimation method for Cox (1972) proportional hazards models by optimizing an approximated information criterion. The main idea involves approximation of the urn:x-wiley:15410420:media:biom12484:biom12484-math-0001 norm with a continuous or smooth unit dent function. The proposed method bridges the best subset selection and regularization by borrowing strength from both. It mimics the best subset selection using a penalized likelihood approach yet with no need of a tuning parameter. We further reformulate the problem with a reparameterization step so that it reduces to one unconstrained nonconvex yet smooth programming problem, which can be solved efficiently as in computing the maximum partial likelihood estimator (MPLE). Furthermore, the reparameterization tactic yields an additional advantage in terms of circumventing postselection inference. The oracle property of the proposed method is established. Both simulated experiments and empirical examples are provided for assessment and illustration.

Number of times cited according to CrossRef: 9

  • Variable selection in joint frailty models of recurrent and terminal events, Biometrics, 10.1111/biom.13242, 0, 0, (2020).
  • A surrogate 0 sparse Cox's regression with applications to sparse high‐dimensional massive sample size time‐to‐event data, Statistics in Medicine, 10.1002/sim.8438, 39, 6, (675-686), (2019).
  • The dynamic of basal ganglia activity with a multiple covariance method: influences of Parkinson’s disease, Brain Communications, 10.1093/braincomms/fcz044, 2, 1, (2019).
  • Cytokine rs361525, rs1800750, rs1800629, rs1800896, rs1800872, rs1800795, rs1800470, and rs2430561 SNPs in relation with prognostic factors in acute myeloid leukemia, Cancer Medicine, 10.1002/cam4.2424, 8, 12, (5492-5506), (2019).
  • The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease, NeuroImage: Clinical, 10.1016/j.nicl.2019.101708, (101708), (2019).
  • Penalized estimation of semiparametric transformation models with interval-censored data and application to Alzheimer’s disease, Statistical Methods in Medical Research, 10.1177/0962280219884720, (096228021988472), (2019).
  • Tuning Parameter Selection in Cox Proportional Hazards Model with a Diverging Number of Parameters, Scandinavian Journal of Statistics, 10.1111/sjos.12313, 45, 3, (557-570), (2018).
  • Variable selection for random effects two-part models, Statistical Methods in Medical Research, 10.1177/0962280218784712, (096228021878471), (2018).
  • The Multiple Correspondence Analysis Method and Brain Functional Connectivity: Its Application to the Study of the Non-linear Relationships of Motor Cortex and Basal Ganglia, Frontiers in Neuroscience, 10.3389/fnins.2017.00345, 11, (2017).

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