Association between periodontitis and salivary 8‐hydroxydeoxyguanosine among Korean rural adults

Abstract

Objectives

This study aimed to evaluate the association between salivary 8‐hydroxydeoxyguanosine (8‐OHdG) and periodontitis among community‐dwelling Korean adults.

Methods

A total of 211 adults (80 men and 131 women) were cross‐sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8‐OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health‐related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8‐OHdG.

Results

The high 8‐OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05–5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log‐transformed value of 8‐OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028).

Conclusions

8‐OHdG was associated with periodontitis. Thus, salivary 8‐OHdG could be a useful marker for periodontitis.