Platelet Clumping in vitro
Abstract
Osler (1874), Hayem (1878) and Eberth and Schimmelbusch (1886) showed that the process of blood clotting initiated platelet clumping in shed blood, and later workers (Roskam, 1922; Zucker and Borrelli, 1955; Bergsagel, 1956; Bounameaux, 1957) have shown that various coagulation factors released during the clotting process can produce this platelet clumping. There has, however, been a growing body of evidence to suggest that other mechanisms, not directly related to clotting, could also initiate platelet clumping (Sharp, 1958, 1961), and the existence of one such mechanism was confirmed by the observation that a protein‐free, heat‐stable, dialysable extract of human red cells could increase platelet adhesiveness (Hellem, 1960). Hellem called the active principle of his extract ‘Factor R’ fractionation of the extract showed that the active agent was adenosine diphosphate (ADP) and it was found that when this substance was added to platelet‐rich citrated plasma in concentrations as low as 0.02 μg./ml., platelet clumping was produced (Gaarder, Jonsen, Laland, Hellem and Owren, 1961).
We have studied this clumping phenomenon in vitro, tested other substances for clumping activity and searched for materials which would modify the process. This paper reports the results of these studies.
Citing Literature
Number of times cited: 140
- Manjinder Singh, Maninder Kaur and Om Silakari, Flavones: An important scaffold for medicinal chemistry, European Journal of Medicinal Chemistry, 10.1016/j.ejmech.2014.07.013, 84, (206-239), (2014).
- Neela Badrie and Jacklyn Broomes, Beneficial uses of Breadfruit (Artocarpus altilis), Bioactive Foods in Promoting Health, 10.1016/B978-0-12-374628-3.00033-5, (491-505), (2010).
- Kai‐Wei Lin, Song‐Chwan Fang, Chi‐Feng Hung, Bor‐Jinn Shieh, Shyh‐Chyun Yang, Che‐Ming Teng and Chun‐Nan Lin, Synthesis, Antiplatelet and Vasorelaxing Activities of Xanthone Derivatives, Archiv der Pharmazie, 342, 1, (19-26), (2008).
- L. F. MOHAMMAD‐ZADEH, L. MOSES and S. M. GWALTNEY‐BRANT, Serotonin: a review, Journal of Veterinary Pharmacology and Therapeutics, 31, 3, (187-199), (2008).
- G. V. R. Born and F. Michal, 5‐Hydroxytryptamine Receptors of Platelets, Ciba Foundation Symposium 35 ‐ Biochemistry and Pharmacology of Platelets, (287-307), (2008).
- Kim-Hong Gan, Chi-Huang Teng, Hsien-Cheng Lin, Kun-Tze Chen, Yu-Chian Chen, Mei-Feng Hsu, Jih-Pyang Wang, Che-Ming Teng and Chun-Nan Lin, Antiplatelet Effect and Selective Binding to Cyclooxygenase by Molecular Docking Analysis of 3-Alkylaminopropoxy-9,10-anthraquinone Derivatives, Biological & Pharmaceutical Bulletin, 31, 8, (1547), (2008).
- Chien-Ming Wu, Shu-Chun Wu, Wan-Jung Chung, Hsien-Cheng Lin, Kun-Tze Chen, Yu-Chian Chen, Mei-Feng Hsu, Jwu-Maw Yang, Jih-Pyang Wang and Chun-Nan Lin, Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans, International Journal of Molecular Sciences, 8, 12, (830), (2007).
- Jing‐Ru Weng, Horng‐Huey Ko, Ting‐Li Yeh, Hsien‐Cheng Lin and Chun‐Nan Lin, Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens, Archiv der Pharmazie, 337, 4, (207-212), (2004).
- Horng‐Huey Ko, Hsin‐Kaw Hsieh, Cheng‐Tsung Liu, Hsien‐Chen Lin, Che‐Ming Teng and Chun‐Nan Lin, Structure‐activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation, Journal of Pharmacy and Pharmacology, 56, 10, (1333-1337), (2010).
- Chun‐Nan Lin, Hsin‐Kaw Hsieh, Horng‐Huey Ko, Mei‐Feng Hsu, Hsien‐Cheng Lin, Ya‐Ling Chang, Mei‐Ing Chung, Jaw‐Jou Kang, Jih‐Pyang Wang and Che‐Ming Teng, Chalcones as potent antiplatelet agents and calcium channel blockers, Drug Development Research, 53, 1, (9-14), (2001).
- CHUN‐NAN LIN, TAI‐HUA LEE, MEI‐FENG HSU, JIH‐PYANG WANG, FENG‐NIEN KO and CHE‐MING TENG, 2′,5′‐Dihydroxychalcone as a Potent Chemical Mediator and Cyclooxygenase Inhibitor, Journal of Pharmacy and Pharmacology, 49, 5, (530-536), (2011).
- Chun‐Nan Lin, Song‐Chwan Fang, Hsien‐Cheng Lin, Feng‐Nien Ko, Bor‐Jinn Shieh, Hong‐Wen Liu and Che‐Ming Teng, Studies on the Synthesis of Some Xanthonoid Derivatives Possessing Antiplatelet Effects, Journal of Pharmacy and Pharmacology, 46, 11, (917-921), (2011).
- John R. Peters, David P. Geaney and D.G. Grahame-Smith, 5-[3H]hydroxytryptamine and [3H]lysergic acid diethylamide binding to human platelets, Platelets: Receptors, Adhesion, Secretion Part B, 10.1016/0076-6879(92)15064-J, (201-213), (1992).
- J. Stuart Fleming, John O. Buchanan, Frank D. Yocca, Lawrence G. Iben and Michael J. Antonaccio, Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT Induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis, Cardiovascular Drugs and Therapy, 5, 4, (763), (1991).
- J.M. Elliott, PERIPHERAL MARKERS IN AFFECTIVE DISORDERS, Biological Aspects of Affective Disorders, 10.1016/B978-0-12-356510-5.50010-8, (95-144), (1991).
- Ramesh C. Arora and Herbert Y. Meltzer, Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients, Life Sciences, 44, 11, (725), (1989).
- Gerald Soslau, Judy Gillen and Janet Parker, Loss of low‐affinity serotonin receptors upon storage of human platelets, Journal of Cellular Physiology, 137, 3, (521-528), (2005).
- Daniel H. Hwang, Species Variation in Platelet Aggregation, The Platelets, 10.1016/B978-0-12-455555-6.50044-8, (289-305), (1985).
- Shirley P. Levine, Augustin J. Suarez, Richard R. Sorenson, Nancy M. Raymond and Linda K. Knieriem, Platelet factor 4 release during exercise in patients with coronary artery disease, American Journal of Hematology, 17, 2, (117-127), (2006).
- Michael D. Gershon and Hadassah Tamir, Serotonectin and the family of proteins that bind serotonin, Biochemical Pharmacology, 33, 20, (3115), (1984).
- Jane Bevan and S. Heptinstall, Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets, Thrombosis Research, 30, 5, (415), (1983).
- Maria Grazia Lampugnani, Giovanni de Gaetano and Ennio C. Rossi, Functional distinction between serotonin uptake and serotonin-induced shape change receptors in rat platelets, Biochimica et Biophysica Acta (BBA) - Biomembranes, 693, 1, (22), (1982).
- Patricia M. Taylor and S. Heptinstall, The Abilities of Human Blood Platelets to Bind Extracellular Calcium and to be Aggregated by Adenosine Diphosphate are Related, British Journal of Haematology, 46, 1, (115-122), (2008).
- Alexander W. Gotta, Patty Gould, Colleen A. Sullivan and Paul L. Goldiner, The effect of enflurane and fentanyl anaesthesia on human platelet aggregationin vivo, Canadian Anaesthetists’ Society Journal, 27, 4, (319), (1980).
- Byung K. Kim, Manfred Steiner and Mario G. Baldini, Serotonin binding sites of human blood platelets, Analytical Biochemistry, 106, 1, (92), (1980).
- John R. Peters and David G. Grahame-Smith, Human platelet 5HT receptors: Characterisation and functional association, European Journal of Pharmacology, 68, 3, (243), (1980).
- M.M. Frojmovic and A. Rotman, Effect of adenosine 5′-diphosphate and shape change on 5-hydroxytryptamine uptake by human blood platelets, Thrombosis Research, 17, 3-4, (507), (1980).
- Michael C Scrutton and C.M Egan, Divalent cation requirements for aggregation of human blood platelets and the role of the anti-coagulant, Thrombosis Research, 14, 4-5, (713), (1979).
- DJ. BOULLIN and PATRICIA A.M. GLENTON, CHARACTERIZATION OF RECEPTORS MEDIATING 5‐HYDROXYTRYPTAMINE‐ AND CATECHOLAMINE‐INDUCED PLATELET AGGREGATION, ASSESSED BY THE ACTIONS OF α‐ AND β‐BLOCKERS, BUTYROPHENONES, 5‐HT ANTAGONISTS AND CHLORPROMAZINE, British Journal of Pharmacology, 62, 4, (537-542), (2012).
- Michael Cohen, David J. Simmons and J.Heinrich Joist, Diurnal hemostatic changes in the rat, Thrombosis Research, 12, 6, (965), (1978).
- KARL H. JAKOBS, Synthetic α-adrenergic agonists are potent α-adrenergic blockers in human platelets, Nature, 274, 5673, (819), (1978).
- S.S. Tang and M.M. Frojmovic, The effects of pCO2 and pH on platelet shape change and aggregation for human and rabbit platelet-rich plasma, Thrombosis Research, 10, 1, (135), (1977).
- Jean-Pierre Cazenave, Hans-Joachim Reimers, Marian A. Packham and J.Fraser Mustard, Effects of reserpine on rabbit platelet aggregation and adherence to collagen or injured rabbit aorta, Biochemical Pharmacology, 26, 2, (149), (1977).
- B. Fox, Venous infarction of the adrenal glands, The Journal of Pathology, 119, 2, (65-89), (2005).
- Akio Wakabayashi, Telford O. Woolley, Yoshimasa Nakamura, Chi‐Chu Chen, Paul J. Mullin, Susie W. Fong and John E. Connolly, Blood coagulation studies during six day heparinless venoarterial bypass in sheep, Journal of Surgical Oncology, 8, 4, (299-304), (2006).
- A.H. DRUMMOND and J.L. GORDON, UPTAKE OF 5‐HYDROXYTRYPTAMINE BY RAT BLOOD PLATELETS AND ITS INHIBITION BY ADENOSINE 5‘‐DIPHOSPHATE, British Journal of Pharmacology, 56, 4, (417-421), (2012).
- Ho Nam Chang and Channing R. Robertson, Platelet aggregation by laminar shear and Brownian motion, Annals of Biomedical Engineering, 4, 2, (151), (1976).
- Vijay Sood and R. N. Chakravarti, Systemic stress in the production of cardiac thrombosis in hypercholesterolaemic rats, Research In Experimental Medicine, 167, 1, (31), (1976).
- S.B. Ross, S. Jansa, L. Wetterberg, B. Fyro and B. Hellner, Decreased blood level of 5-hydroxytryptamine by inhibitors of the membranal 5-hydroxytryptamine uptake, Life Sciences, 19, 2, (205), (1976).
- Jacob I. Haft and Yale S. Arkel, Effect of Emotional Stress on Platelet Aggregation in Humans, Chest, 70, 4, (501), (1976).
- Alan H. Drummond, Kathryn A.E. Whigham and Colin R.M. Prentice, Effects of chlorprothixene isomers on platelet 5-hydroxytryptamine receptors: Evidence for different 5-hydroxytryptamine conformations at uptake and stimultory sites, European Journal of Pharmacology, 37, 2, (385), (1976).
- K.C. Agarwal and M. Steiner, Effect of serotonin on cyclic nucleotides of human platelets, Biochemical and Biophysical Research Communications, 69, 4, (962), (1976).
- Kaneo Yamada, Akira Shirahata and Takashi Meguro, The effects of an alpha blocking agent on the respiratory distress syndrome with disseminated intravascular coagulation in the newborn infants and experimental animals, Thrombosis Research, 8, (179), (1976).
- Ennio C. Rossi, Platelets and thrombosis, Journal of Chronic Diseases, 29, 4, (215), (1976).
- Alan I. Fleischman, Marvin L. Bierenbaum and Arleane Stier, Effect of Stress Due to Anticipated Minor Surgery upon in Vivo Platelet Aggregation in Humans, Journal of Human Stress, 2, 1, (33), (1976).
- John L. Gordon and Alan H. Drummond, Irreversible aggregation of pig platelets and release of intracellular constituents induced by 5-hydroxytryptamine, Biochemical Pharmacology, 24, 1, (33), (1975).
- Wang Yao-Chun, Ghanshyam N. Pandey, Joe Mendels and Alan Frazer, Effect of lithium on prostaglandin E1− stimulated adenylate cyclase activity of human platelets, Biochemical Pharmacology, 23, 4, (845), (1974).
- R. Thomas Solis, George P. Noon, Arthur C. Beall and Michael E. DeBakey, Particulate Microembolism During Cardiac Operation, The Annals of Thoracic Surgery, 17, 4, (332), (1974).
- Wolfgang Barthel and Fritz Markwardt, Aggregation of blood platelets by biogenic amines and its inhibition by antiadrenergic and antiserotoninergic agents, Biochemical Pharmacology, 23, 1, (37), (1974).
- Elena G. Puszkin and Louis M. Aledort, Biochemistry and Physiology, Blood, 10.1016/B978-0-12-595705-2.50012-4, (177-198), (1974).
- Thomas Wuppermann and Helmut H�rmann, Biochemische Prozesse bei der Ausl�sung der Blutgerinnung durch Kollagen, Klinische Wochenschrift, 52, 9, (409), (1974).
- Frank A. Belamarich and Lynda W. Simoneit, Aggregation of duck thrombocytes by 5-hydroxytryptamine, Microvascular Research, 6, 2, (229), (1973).
- R.G. MACFARLANE, The Inflammatory Process, (335), (1973).
- Alan Salinger, I.Leonard Bernstein and Helen I. Glueck, The effect of epinephrine on platelet aggregation in normal and atopic subjects, Journal of Allergy and Clinical Immunology, 51, 1, (29), (1973).
- Jacob I Haft, Paul D Kranz, Frank Albert and Rolf Oestreicher, Protection against epinephrine induced myocardial necrosis with clofibrate, American Heart Journal, 86, 6, (805), (1973).
- O. Tangen, E. L. McKinnon and H. J. Berman, On the Fine Structure and Aggregation Requirements of Gel Filtered Platelets (GFP), Scandinavian Journal of Haematology, 10, 2, (96-105), (2009).
- Elmer L. Becker and Peter M. Henson, In Vitro Studies of Immunologically Induced Secretion of Mediators from Cells and Related Phenomena, , 10.1016/S0065-2776(08)60732-4, (93-193), (1973).
- F. A. Dolbeare, Platelet Aggregation as a Quantitative Immunologic Technique, Immunological Communications, 2, 1, (65), (1973).
- CHUNG‐HSIN TS'AO and SEYMOUR GLAGOV, Effects of Compound 48/80 on Platelets: Structural Alterations and Inhibition of Aggregation, Scandinavian Journal of Haematology, 9, 1‐6, (73-82), (2009).
- C. EIKA, On the Mechanism of Platelet Aggregation Induced by Heparin, Protamine and Polybrene, Scandinavian Journal of Haematology, 9, 1‐6, (248-257), (2009).
- G. V. R. BORN, KANCHANA JUENGJAROEN and F. MICHAL, Relative activities on and uptake by human blood platelets of 5‐hydroxytryptamine and several analogues, British Journal of Pharmacology, 44, 1, (117-139), (2012).
- David R. Phillips, Effect of trypsin on the exposed polypeptides and glycoproteins in the human platelet membrane, Biochemistry, 11, 24, (4582), (1972).
- J. Fraser Mustard, Raelene L. Kinlough‐Rathbone, Charles S. P. Jenkins and Marian A. Packham, MODIFICATION OF PLATELET FUNCTION, Annals of the New York Academy of Sciences, 201, 1, (343-359), (2006).
- B.A. Warren and O. Vales, The adhesive dendritic pseudopodium of the platelet and the release reaction, Microvascular Research, 4, 2, (159), (1972).
- Jacob I. Haft, Kenneth Gershengorn, Paul D. Kranz and Rolf Oestreicher, Protection against epinephrine-induced myocardial necrosis by drugs that inhibit platelet aggregation, The American Journal of Cardiology, 30, 8, (838), (1972).
- H.Bruce Bosmann, Platelet adhesiveness and aggregation, Biochimica et Biophysica Acta (BBA) - General Subjects, 279, 3, (456), (1972).
- Gürler Iliçin, Argun Saylam and A. Yüksel Bozer, The Effect of Extracorporeal Circulation on Serotonin Metabolism, The Annals of Thoracic Surgery, 13, 3, (225), (1972).
- Ennio C. Rossi, The Function of Platelets in Hemostasis, Medical Clinics of North America, 56, 1, (25), (1972).
- P. N. Walsh, Albumin Density Gradient Separation and Washing of Platelets and the Study of Platelet Coagulant Activities, British Journal of Haematology, 22, 2, (205-217), (2008).
- J. F. Mustard, D. W. Perry, N. G. Ardlie and M. A. Packham, Preparation of Suspensions of Washed Platelets from Humans, British Journal of Haematology, 22, 2, (193-204), (2008).
- François M. Booyse, Thomas P. Hoveke, Donna Kisieleski and Max E. Rafelson, Mechanism and control of platelet-platelet interaction, Microvascular Research, 4, 2, (179), (1972).
- Marion I. Barnhart, R. T. Walsh and Jennifer A. Robinson, A THREE‐DIMENSIONAL VIEW OF PLATELET RESPONSES TO CHEMICAL STIMULI*, Annals of the New York Academy of Sciences, 201, 1, (360-390), (2006).
- D. Bottecchia, Influence of histamine or histamine-liberator (48/80) on the ADP-induced platelet aggregation, Experientia, 28, 5, (564), (1972).
- L. M. Aledort, H. S. Gilbert and E. Puszkin, Patterns of Endogenous Platelet Serotonin Release, Transfusion, 11, 5, (266-269), (2009).
- LOUIS M. ALEDORT, PLATELET AGGREGATION**This research was supported in part by USPHS Grant No. HE 10905 and USPHS Contract No. PH-43-67-1359 from the National Heart Institute, the Hemophilia Foundation, and by the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Funds., The Circulating Platelet, 10.1016/B978-0-12-387550-1.50015-8, (259-281), (1971).
- John Hampton, Trends in the development of antithrombotic agents, The American Journal of Cardiology, 27, 6, (659), (1971).
- Shigehiko Shionoya, Yukifumi Nakata, Kisaku Kamiya, Akio Inagaki and Takashi Yano, Influences of Bradykinin On the Microcirculation, Angiology, 22, 8, (456), (1971).
- HERBERT I. HOROWITZ and ARTHUR R. SPIELVOGEL, Hemostasis, Thrombosis and Bleeding Disorders, 10.1016/B978-0-12-077750-1.50013-1, (412-456), (1971).
- J. Swedenborg, Thrombin-Induced Vasoconstriction in the Pulmonary Circulation, Scandinavian Journal of Clinical and Laboratory Investigation, 27, 4, (321), (1971).
- N. G. Ardlie, M. A. Packham and J. F. Mustard, Adenosine Diphosphate‐induced Platelet Aggregation in Suspensions of Washed Rabbit Platelets, British Journal of Haematology, 19, 1, (7-17), (2008).
- James G. White, A Biphasic Response of Platelets to Serotonin, Scandinavian Journal of Haematology, 7, 3, (145-151), (2009).
- O. Behnke, Effects of Some Chemicals on Blood Platelet Microtubules, Platelet Shape and Some Platelet Functions in vitro, Scandinavian Journal of Haematology, 7, 2, (123-140), (2009).
- J.N. Mehrishi, Positively charged amino groups on the surface of normal and cancer cells, European Journal of Cancer (1965), 6, 2, (127), (1970).
- BRYN M. JONES, RICHARD B. KEMP and UTE GRÖSCHEL-STEWART, Inhibition of Cell Aggregation by Antibodies directed against Actomyosin, Nature, 226, 5242, (261), (1970).
- J. A. Shively, Cora L. Gott and D. S. Jongh, The Effect of Storage on Adhesion and Aggregation of Platelets, Vox Sanguinis, 18, 3, (204-215), (2009).
- M. Horlington and P.A. Watson, Inhibition of 3′5′-cyclic-AMP phosphodiesterase by some platelet aggregation inhibitors, Biochemical Pharmacology, 19, 3, (955), (1970).
- A. Angrist, M. Oka and K. Nakao, INTERSTITIAL EDEMA IN VALVULAR ENDOCARDITIS, Annals of the New York Academy of Sciences, 156, 1, (480-497), (2006).
- S. Bygdeman and Ø. Johnsen, Studies on the Effect of Adrenergic Blocking Drugs on Catecholamine‐Induced Platelet Aggregation and Uptake of Noradrenaline and 5‐Hydroxytryptamine, Acta Physiologica Scandinavica, 75, 1‐2, (129-138), (2008).
- T. J. RYAN and P. W. M. COPEMAN, MICROVASCULAR PATTERN AND BLOOD STASIS IN SKIN DISEASE, British Journal of Dermatology, 81, 8, (563-573), (2006).
- EDWIN W. SALZMAN and LENA L. NERI, Cyclic 3′,5′-Adenosine Monophosphate in Human Blood Platelets, Nature, 224, 5219, (609), (1969).
- Ennino C. Rossi, Platelets and hemostasis, Journal of Chronic Diseases, 21, 9-10, (607), (1969).
- BERNARD MAUPIN, BIBLIOGRAPHY, Blood Platelets in Man and Animals, 10.1016/B978-1-4832-8297-8.50020-2, (1-487), (1969).
- E. Irion and Margareta Blombäck, Prostaglandins in Platelet Aggregation, Scandinavian Journal of Clinical and Laboratory Investigation, 24, 2, (141), (1969).
- Oscar D. Ratnoff, Some Relationships among Hemostasis, Fibrinolytic Phenomena, Immunity, and the Inflammatory Response, , 10.1016/S0065-2776(08)60417-4, (145-227), (1969).
- James G. White, Effects of Atropine on Platelet Structure and Function, Scandinavian Journal of Haematology, 6, 4, (236-245), (2009).
- , REFERENCES, Acta Medica Scandinavica, 183, S486, (43-54), (2009).
- Arne Nordöy, James T. Hamlin, Arthur B. Chandler and Hillery Newland, The Influence of Dietary Fats on Plasma and Platelet Lipids and ADP Induced Platelet Thrombosis in the Rat, Scandinavian Journal of Haematology, 5, 6, (458-473), (2009).
- N. Mourad, Studies on Release of Certain Enzymes from Human Platelets, Transfusion, 8, 6, (363-367), (2009).
- H. R. BAUMGARTNER and G. V. R. BORN, Effects of 5-Hydroxytryptamine on Platelet Aggregation, Nature, 218, 5137, (137), (1968).
- M.A. Packham, E.E. Nishizawa and J.F. Mustard, Response of platelets to tissue injury, Biochemical Pharmacology, 17, (171), (1968).
- M. HELEN MAGUIRE and FRANK MICHAL, Powerful New Aggregator of Blood Platelets—2-Chloroadenosine-5′-diphosphate, Nature, 217, 5128, (571), (1968).
- James G. White, Effects of Ethylenediamine Tetracetic Acid (EDTA) on Platelet Structure, Scandinavian Journal of Haematology, 5, 4, (241-254), (2009).
- , Platelets and Thrombosis, Scottish Medical Journal, 13, 12, (430), (1968).
- KjellA Gröttum, INFLUENCE OF AGGREGATING AGENTS ON ELECTROPHORETIC MOBILITY OF BLOOD PLATELETS FROM HEALTHY INDIVIDUALS AND FROM PATIENTS WITH CARDIOVASCULAR DISEASES, The Lancet, 291, 7557, (1406), (1968).
- E. Weber and E. Morgenstern, Biochemische und cytologische untersuchungen zur wirkung von adeninnucleotiden auf blutplättchen in vitro, Biochemical Pharmacology, 17, 3, (439), (1968).
- P. M. Mannucci and A. A. Sharp, Platelet Volume and Shape in Relation to Aggregation and Adhesion, British Journal of Haematology, 13, s1, (604-617), (2008).
- D. C. B. MILLS and G. C. K. ROBERTS, Membrane Active Drugs and the Aggregation of Human Blood Platelets, Nature, 213, 5071, (35), (1967).
- R. Mark Vetto, Folkert O. Belzer, Richard C. Rogers and Hatsumi Y. Park, Rapid flow, isolated renal perfusion, Journal of Surgical Research, 7, 11, (520), (1967).
- MANABU YAMANAKA, JUNICHI ISOBE and YASUTA KONO, Effect of Adenosine Diphosphate on Adhesiveness of Platelets in vitro and in vivo, Nature, 216, 5111, (175), (1967).
- P. Millac, Adrenocorticotrophic hormone and platelet stickiness, Journal of the Neurological Sciences, 4, 1, (151), (1967).
- J.R. Hampton, The study of platelet behaviour and its relevance to thrombosis, Journal of Atherosclerosis Research, 7, 6, (729), (1967).
- M.J.G. Harrison, P.R. Emmons and J.R.A. Mitchell, The variability of human platelet aggregation, Journal of Atherosclerosis Research, 7, 2, (197), (1967).
- J.M. Bridges, Anne M. Dalby, D.R. Hadden, Hilary A. Johnston and J.A. Weaver, The effect of “in-vivo” alteration of free fatty acids on platelet stickiness, Journal of Atherosclerosis Research, 7, 5, (695), (1967).
- WALTER H. SEEGERS, Blood Clotting Enzymology, (1), (1967).
- R.G Mason and M.S Read, Platelet response to six agglutinating agents: Species similarities and differences, Experimental and Molecular Pathology, 6, 3, (370), (1967).
- P. Barkhan, Platelet Survival Studies in Man with Diisopropylphosphorofluoridate (DF32P). SOME OBSERVATIONS IN PATIENTS WITH HYPOCOAGULABILITY, ‘HYPERCOAGULABILITY’ AND PLATELET DISORDERS*, British Journal of Haematology, 12, 1, (25-36), (2008).
- H. C. Rowsell, B. Hegardt, H. G. Downie, J. F. Mustard and E. A. Murphy, Adrenaline and Experimental Thrombosis*, British Journal of Haematology, 12, 1, (66-73), (2008).
- J. F. Mustard, H. C. Rowsell and E. A. Murphy, Platelet Economy (Platelet Survival and Turnover)*, British Journal of Haematology, 12, 1, (1-24), (2008).
- J. R. HAMPTON and J. R. A. MITCHELL, Modification of the Electrokinetic Response of Blood Platelets to Aggregating Agents, Nature, 210, 5040, (1000), (1966).
- JAY W. CONSTANTINE, Aggregation of Guinea-Pig Platelets by Adenosine Diphosphate, Nature, 210, 5032, (162), (1966).
- J.M. Bridges and J.A. Weaver, Platelet stickiness, American Heart Journal, 71, 3, (291), (1966).
- EDWIN W. SALZMAN, DONALD A. CHAMBERS and LENA L. NERI, Possible Mechanism of Aggregation of Blood Platelets by Adenosine Diphosphate, Nature, 210, 5032, (167), (1966).
- G.V.F. Seaman and P.S. Vassar, Changes in the electrokinetic properties of platelets during their aggregation, Archives of Biochemistry and Biophysics, 117, 1, (10), (1966).
- Duncan P. Thomas, Victor Gurewich and Thomas P. Ashford, Platelet Adherence to Thromboemboli in Relation to the Pathogenesis and Treatment of Pulmonary Embolism, New England Journal of Medicine, 274, 17, (953), (1966).
- JAY W. CONSTANTINE and F. A. HOCHSTEIN, Aggregation of Rabbit and Guinea-Pig Platelets by Oxime Esters, Nature, 210, 5032, (164), (1966).
- N. G. ARDLIE, G. GLEW and C. J. SCHWARTZ, Influence of Catecholamines on Nucleotide-induced Platelet Aggregation, Nature, 212, 5060, (415), (1966).
- R.C. Graham and Robert H. Ebert, Observations On the Effects of Histamine and Serotonin in the Rabbit Ear Chamber, Angiology, 17, 6, (402), (1966).
- ANEURIN HUGHES and R. S. TONKS, Magnesium, Adenosine Diphosphate and Blood Platelets, Nature, 210, 5031, (106), (1966).
- F. A. Flatow, R. H. Levin and E. J. Freireich, Preparation of Platelet Concentrates for Transfusion Employing Adenosine Diphosphate*, Transfusion, 6, 3, (205-212), (2009).
- F. MICHAL and R. H. THORP, Enhanced Adenosine Inhibition of Platelet Aggregation in the Presence of Cardiac Glycosides, Nature, 209, 5019, (208), (1966).
- G. Evans and W.T. Irvine, LONG-TERM ARTERIAL-GRAFT PATENCY IN RELATION TO PLATELET ADHESIVENESS, BIOCHEMICAL FACTORS, AND ANTICOAGULANT THERAPY, The Lancet, 288, 7459, (353), (1966).
- J.F. Mustard, H.C. Rowsell, F. Lotz, B. Hegardt and E.A. Murphy, The effect of adenine nucleotides on thrombus formation, platelet count, and blood coagulation, Experimental and Molecular Pathology, 5, 1, (43), (1966).
- P.R. Emmons and J.R.A. Mitchell, POSTOPERATIVE CHANGES IN PLATELET-CLUMPING ACTIVITY, The Lancet, 285, 7376, (71), (1965).
- A. A. Sharp, Present Status of Platelet Aggregation, New England Journal of Medicine, 272, 2, (89), (1965).
- Herbert I. Horowitz, Herbert I. Rappaport, Robert C. Young and MlTSU M. FUJIMOTO, Change in Platelet Factor 3 as a Means of Demonstrating Immune Reactions Involving Platelets: Its Use as a Test for Quinidine‐Induced Thrombocytopenia, Transfusion, 5, 4, (336-343), (2009).
- C. R. Valeri, Observations on Recipient Plasma Hemoglobin Concentration after Transfusion with Glycerolized Frozen Blood, Transfusion, 5, 1, (36-53), (2009).
- R.G. MACFARLANE, The Inflammatory Process, (465), (1965).
- R. M. Hardisty, Katharine M. Dormandy and R. A. Hutton, Thrombasthenia, British Journal of Haematology, 10, 3, (371-387), (2008).
- Joan Slack, John Seymour, Lawson Mcdonald and Fiona Love, LIPOPROTEIN-LIPASE LEVELS AND PLATELET STICKINESS IN PATIENTS WITH ISCHÆMIC HEART-DISEASE AND IN CONTROLS, DISTINGUISHING THOSE WITH AN AFFECTED FIRST-DEGREE RELATIVE, The Lancet, 284, 7368, (1033), (1964).
- G. V. R. BORN, A. J. HONOUR and J. R. A. MITCHELL, Inhibition by Adenosine and by 2-Chloroadenosine of the Formation and Embolization of Platelet Thrombi, Nature, 202, 4934, (761), (1964).
