Abstract
Title. Adherence: a concept analysis.
Aim. This paper is a report of an analysis of the concept of adherence.
Background. The transition in terminology from compliance to adherence, and more recently to concordance, requires re‐clarification of ‘adherence’ as a concept in nursing practice. Differences exist in the use of the term adherence and how or if it differs from compliance or concordance.
Data sources. Using the Medical Subject Headings terms adherence, non‐adherence and treatment refusal, the Cumulative Index to Nursing and Allied Health Literature, Medline, PsychINFO and Cochrane library databases were searched for publications between 1970 and 2007.
Method. The evolutionary analytic method was used to identify and explore transitions in the concept of adherence over time and across healthcare disciplines. A representative sample of papers was identified from the disciplines of nursing, medicine, psychology and pharmacy.
Results. We identified 114 papers: 27 from nursing, 39 from psychology, 33 from general medicine and 15 from pharmacology sources. The final sample included eight from pharmacy and 15 from mental health, medicine and nursing. We found no distinct differentiation between adherence and compliance. The surrogate terms serving as manifestations of adherence are concordance, agreement, cooperation and partnership. The most common definition found was as follows: ‘Adherence can be defined as the extent to which patients follow the instructions they are given for prescribed treatments’. No definition of adherence exists that reflects a patient‐centred approach, the dynamic nature of adherence behaviour and the power imbalance implied by these terms.
Conclusion. This concept analysis of adherence is a preliminary step towards broadening nurses’ appreciation of the complexity of patient adherence behaviour.
Citing Literature
Number of times cited according to CrossRef: 68
- MaryamKhoshbakht Pishkhani, Asghar Dalvandi, Abbas Ebadi, MohammadAli Hosseini, Adherence to a Rehabilitation Regimen in Stroke Patients: A Concept Analysis, Iranian Journal of Nursing and Midwifery Research, 10.4103/ijnmr.IJNMR_170_18, 25, 2, (139), (2020).
- Micah A. Skeens, Cynthia A. Gerhardt, Rajinder Bajwa, Terrah Foster Akard, Toward a better understanding: An exploration of provider perceptions in pediatric hematopoietic stem cell transplant adherence, Pediatric Transplantation, 10.1111/petr.13786, 24, 6, (2020).
- B. P. Hromovyk, I. V. Gadyak, МОДЕЛЮВАННЯ КОНЦЕПЦІЇ ФАРМАЦЕВТИЧНОЇ ДОПОМОГИ ХВОРИМ НА ХРОНІЧНИЙ ПРОСТАТИТ, Фармацевтичний часопис, 10.11603/2312-0967.2020.1.10941, 1, (89-96), (2020).
- John Devin Peipert, Sherif M Badawy, Sharon H Baik, Laura B Oswald, Fabio Efficace, Sofia F Garcia, Daniel K Mroczek, Michael Wolf, Karen Kaiser, Betina Yanez, David Cella,
Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Medication Adherence Scale (PMAS)
, Patient Preference and Adherence, 10.2147/PPA.S249079, Volume 14, (971-983), (2020). - Mojtaba Vaismoradi, Susanna Tella, Patricia A. Logan, Jayden Khakurel, Flores Vizcaya-Moreno, Nurses’ Adherence to Patient Safety Principles: A Systematic Review, International Journal of Environmental Research and Public Health, 10.3390/ijerph17062028, 17, 6, (2028), (2020).
- Martha J. Biddle, Debra K. Moser, Michele M. Pelter, Susan Robinson, Kathleen Dracup, Predictors of Adherence to Self‐Care in Rural Patients With Heart Failure, The Journal of Rural Health, 10.1111/jrh.12405, 36, 1, (120-129), (2019).
- Ramsés Djidjou‐Demasse, Gbenga J. Abiodun, Abiodun M. Adeola, Joel O. Botai, Development and analysis of a malaria transmission mathematical model with seasonal mosquito life‐history traits, Studies in Applied Mathematics, 10.1111/sapm.12296, 144, 4, (389-411), (2019).
- Lara N. Coughlin, Maureen A. Walton, Richard McCormick, Frederic C. Blow, Prevalence and Severity of Alcohol and Cannabis Use Across the Urban‐Rural Continuum in the Michigan National Guard, The Journal of Rural Health, 10.1111/jrh.12412, 36, 2, (234-239), (2019).
- Xingrui Wang, Shane K. Mitchell, Ellen H. Rumley, Philipp Rothemund, Christoph Keplinger, High‐Strain Peano‐HASEL Actuators, Advanced Functional Materials, 10.1002/adfm.201908821, 30, 7, (2019).
- Katharine Heathcote, Martin Wullschleger, Ben Gardiner, Geoffrey Morgan, Holly Barbagello, Jing Sun, The Importance of Place of Residence on Hospitalized Outcomes for Severely Injured Trauma Patients: A Trauma Registry Analysis, The Journal of Rural Health, 10.1111/jrh.12407, 36, 3, (381-393), (2019).
- Kelsey L. Lynch, Linda R. Gooding, Charlie Garnett‐Benson, David A. Ornelles, Daphne C. Avgousti, Epigenetics and the dynamics of chromatin during adenovirus infections, FEBS Letters, 10.1002/1873-3468.13697, 593, 24, (3551-3570), (2019).
- Maryam Khoshbakht Pishkhani, Asghar Dalvandi, Abbas Ebadi, Mohammadali Hosseini, Factors affecting adherence to rehabilitation in Iranian stroke patients: A qualitative study, Journal of Vascular Nursing, 10.1016/j.jvn.2019.07.001, (2019).
- Menna Lloyd Jones, Wound Care. What is new in best practice: addressing the complexities in the management of venous leg ulcers. Part 2, British Journal of Healthcare Assistants, 10.12968/bjha.2019.13.11.540, 13, 11, (540-543), (2019).
- Eileen Danaher Hacker, Physical Activity and Exercise Adherence in People With Hematologic Malignancies, The Journal for Nurse Practitioners, 10.1016/j.nurpra.2019.04.016, (2019).
- Feka Pepić, Sabina Čongo, Edina Gafić, Vladimir Biočanin, Dušan Đurić, Efficacy of adherence and compliance assessment in patients with chronic diseases, PONS - medicinski casopis, 10.5937/pomc16-17888, 16, 1, (32-36), (2019).
- Harald Heinrichs, Artful sustainability governance—Foundational considerations on sensory‐informed policymaking for sustainable development, Sustainable Development, 10.1002/sd.2029, 0, 0, (2019).
- Linda A. M. Khong, Amma Buckley, Wendy Johnson, Vinicius Cavalheri, Lower limb chronic edema management program: Perspectives of disengaged patients on challenges, enablers and barriers to program attendance and adherence, PLOS ONE, 10.1371/journal.pone.0219875, 14, 11, (e0219875), (2019).
- Elizabeth J. Straus, Helen J. Brown, The potential contribution of critical theories in healthcare transition research and practice, Disability and Rehabilitation, 10.1080/09638288.2019.1700566, (1-9), (2019).
- Marina Arkkukangas, Anne Söderlund, Staffan Eriksson, Ann-Christin Johansson, One-Year Adherence to the Otago Exercise Program With or Without Motivational Interviewing in Community-Dwelling Older Adults, Journal of Aging and Physical Activity, 10.1123/japa.2017-0009, 26, 3, (390-395), (2018).
- Andrew E. Levy, Carrie Huang, Allen Huang, P. Michael Ho, Recent Approaches to Improve Medication Adherence in Patients with Coronary Heart Disease: Progress Towards a Learning Healthcare System, Current Atherosclerosis Reports, 10.1007/s11883-018-0707-0, 20, 1, (2018).
- Pajaree Mongkhon, Darren M Ashcroft, C Norman Scholfield, Chuenjid Kongkaew, Hospital admissions associated with medication non-adherence: a systematic review of prospective observational studies, BMJ Quality & Safety, 10.1136/bmjqs-2017-007453, 27, 11, (902-914), (2018).
- Laura Iacorossi, Francesca Gambalunga, Alessandra Fabi, Diana Giannarelli, Anna Marchetti, Michela Piredda, Maria Grazia De Marinis, Adherence to Oral Administration of Endocrine Treatment in Patients With Breast Cancer, Cancer Nursing, 10.1097/NCC.0000000000000452, 41, 1, (E57-E63), (2018).
- Cho Rong Gil, Kyung Mi Sung, Difficulties of Treatment Adherence in Adult Patients with Hemodialysis, The Korean Journal of Rehabilitation Nursing, 10.7587/kjrehn.2018.71, 21, 2, (71-82), (2018).
- Julia Menichetti, Guendalina Graffigna, Aslak Steinsbekk, What are the contents of patient engagement interventions for older adults? A systematic review of randomized controlled trials, Patient Education and Counseling, 10.1016/j.pec.2017.12.009, 101, 6, (995-1005), (2018).
- Laura Iacorossi, Francesca Gambalunga, Rosaria De Domenico, Valeria Serra, Cristina Marzo, Paolo Carlini, Qualitative study of patients with metastatic prostate cancer to adherence of hormone therapy, European Journal of Oncology Nursing, 10.1016/j.ejon.2018.11.004, (2018).
- Mari Kangasniemi, Marina Hirjaba, Katja Kohonen, Ercole Vellone, Tanja Moilanen, Anna‐Maija Pietilä, The cardiac patients’ perceptions of their responsibilities in adherence to care: a qualitative interview study, Journal of Clinical Nursing, 10.1111/jocn.13642, 26, 17-18, (2583-2592), (2017).
- Karen M. Ragaisis, Psychiatric Inpatient Nurses' Perceptions of Using Motivational Interviewing, Issues in Mental Health Nursing, 10.1080/01612840.2017.1377328, 38, 11, (945-955), (2017).
- Izaak L. Williams, David Mee-Lee, Coparticipative Adherence: The Reconstruction of Discharge Categories in the Treatment of Substance Use Disorders, Alcoholism Treatment Quarterly, 10.1080/07347324.2017.1322432, 35, 3, (279-297), (2017).
- Tamara O. Perdue, J. Todd Jackson, Christine Herring, Kathryn Garren, R. Anthony Yocum, Melvin Swanson, Ann Marie Nye, Medication Simulation Affects Health Provider Studentsʼ Attitudes About Adherence and Concordance, Simulation in Healthcare: The Journal of the Society for Simulation in Healthcare, 10.1097/SIH.0000000000000244, 12, 5, (308-313), (2017).
- Trisha Dunning, Medicines and older people: Polypharmacy, adherence and safety, International Diabetes Nursing, 10.1080/20573316.2017.1352142, 14, 1, (10-15), (2017).
- Fanny Nadia Dissak-Delon, Guy-Roger Kamga, Perrine Claire Humblet, Annie Robert, Jacob Souopgui, Joseph Kamgno, Marie José Essi, Stephen Mbigha Ghogomu, Isabelle Godin, Adherence to ivermectin is more associated with perceptions of community directed treatment with ivermectin organization than with onchocerciasis beliefs, PLOS Neglected Tropical Diseases, 10.1371/journal.pntd.0005849, 11, 8, (e0005849), (2017).
- Richard Ofori-Asenso, Ella Zomer, Andrea Curtis, Andrew Tonkin, Mark Nelson, Manoj Gambhir, Danny Liew, Sophia Zoungas, Patterns and Predictors of Adherence to Statin Therapy Among Older Patients: Protocol for a Systematic Review, JMIR Research Protocols, 10.2196/resprot.7195, 6, 3, (e39), (2017).
- Pallav Deka, Bunny Pozehl, Mark A. Williams, Bernice Yates, Adherence to recommended exercise guidelines in patients with heart failure, Heart Failure Reviews, 10.1007/s10741-016-9584-1, 22, 1, (41-53), (2016).
- Debra K. Moser, Cynthia Arslanian-Engoren, Martha J. Biddle, Misook Lee Chung, Rebecca L. Dekker, Muna H. Hammash, Gia Mudd-Martin, Abdullah S. Alhurani, Terry A. Lennie, Psychological Aspects of Heart Failure, Current Cardiology Reports, 10.1007/s11886-016-0799-5, 18, 12, (2016).
- Alejandra Hurtado-de-Mendoza, Mark L. Cabling, Tania Lobo, Chiranjeev Dash, Vanessa B. Sheppard, Behavioral Interventions to Enhance Adherence to Hormone Therapy in Breast Cancer Survivors: A Systematic Literature Review, Clinical Breast Cancer, 10.1016/j.clbc.2016.03.006, 16, 4, (247-255.e3), (2016).
- Marilyn Macdonald, Ruth Martin-Misener, Melissa Helwig, Lisa Janette Smith, Christina M. Godfrey, Janet Curran, Andrea Murphy, Experiences of adults with cystic fibrosis in adhering to medication regimens, JBI Database of Systematic Reviews and Implementation Reports, 10.11124/JBISRIR-2016-002362, 14, 5, (258-285), (2016).
- Logan Trenaman, Anna Selva, Sophie Desroches, Kavita Singh, Janice Bissonnette, Nick Bansback, Dawn Stacey, A measurement framework for adherence in patient decision aid trials applied in a systematic review subanalysis, Journal of Clinical Epidemiology, 10.1016/j.jclinepi.2016.03.032, 77, (15-23), (2016).
- Esperanza Vélez‐Vélez, Ricardo J. Bosch, Illness perception, coping and adherence to treatment among patients with chronic kidney disease, Journal of Advanced Nursing, 10.1111/jan.12873, 72, 4, (849-863), (2015).
- Alejandra Hurtado‐de‐Mendoza, Mark L Cabling, Vanessa B Sheppard, Rethinking agency and medical adherence technology: applying Actor Network Theory to the case study of Digital Pills, Nursing Inquiry, 10.1111/nin.12101, 22, 4, (326-335), (2015).
- Sherri Stevens, Preventing 30-day Readmissions, Nursing Clinics of North America, 10.1016/j.cnur.2014.10.010, 50, 1, (123-137), (2015).
- Ying-Tzu Chang, Ling-Ling Lee, The effectiveness of compliance therapy on drug attitude among schizophrenic patients: a systematic review, JBI Database of Systematic Reviews and Implementation Reports, 10.11124/01938924-201513070-00017, 13, 7, (213-240), (2015).
- Ibrahim Shady, Determinants of Adherence with Malaria Chemoprophylactic Drugs Used in a Traveler’s Health Clinic, Journal of Tropical Medicine, 10.1155/2015/163716, 2015, (1-9), (2015).
- Kristiina Hyrkas, Marjorie Wiggins, A comparison of usual care, a patient‐centred education intervention and motivational interviewing to improve medication adherence and readmissions of adults in an acute‐care setting, Journal of Nursing Management, 10.1111/jonm.12221, 22, 3, (350-361), (2014).
- Anna Hegedüs, Bernd Kozel, Does adherence therapy improve medication adherence among patients with schizophrenia? A systematic review, International Journal of Mental Health Nursing, 10.1111/inm.12089, 23, 6, (490-497), (2014).
- Lai Wah Lam, Diana T.F. Lee, Ann T.Y. Shiu, The dynamic process of adherence to a renal therapeutic regimen: Perspectives of patients undergoing continuous ambulatory peritoneal dialysis, International Journal of Nursing Studies, 10.1016/j.ijnurstu.2013.10.012, 51, 6, (908-916), (2014).
- Faye Hirons, Treating Turner syndrome: a patient's perspective, British Journal of Nursing, 10.12968/bjon.2014.23.Sup6a.S15, 23, Sup6a, (S15-S15), (2014).
- LaShawn Wordlaw-Stinson, Sierra Jones, Shaneese Little, Laura Fish, Adriana Vidal, Cathrine Hoyo, Jennifer S. Smith, Patricia G. Moorman, Challenges and Recommendations to Recruiting Women Who Do Not Adhere to Follow-Up Gynecological Care, Open Journal of Preventive Medicine, 10.4236/ojpm.2014.43017, 04, 03, (123-128), (2014).
- Peter Laing, Growth failure and hormone therapy, British Journal of Nursing, 10.12968/bjon.2014.23.Sup6a.S3, 23, Sup6a, (S3-S9), (2014).
- Marilyn Macdonald, Ruth Martin-Misener, Melissa Helwig, Lisa Janette Smith, Christina M Godfrey, The experiences of adults with cystic fibrosis in adhering to medication regimens: a systematic review protocol, JBI Database of Systematic Reviews and Implementation Reports, 10.11124/jbisrir-2014-1525, 12, 12, (91-105), (2014).
- Austyn Snowden, Colin Martin, Billy Mathers, Allan Donnell, Concordance: a concept analysis, Journal of Advanced Nursing, 10.1111/jan.12147, 70, 1, (46-59), (2013).
- Rana Ahmed, Parisa Aslani, What is patient adherence? A terminology overview, International Journal of Clinical Pharmacy, 10.1007/s11096-013-9856-y, 36, 1, (4-7), (2013).
- Jenny Wright, Jennie Walker, Medication adherence in Parkinson's, British Journal of Nursing, 10.12968/bjon.2013.22.12.686, 22, 12, (686-689), (2013).
- Trisha Dunning AM, Medicine Self‐Management: More than Just Taking Pills, Diabetes Education, 10.1002/9781118702666, (177-199), (2012).
- Claire Marant, Juliette Longin, Rémi Gauchoux, Benoit Arnould, Céderic Spizak, Alexia Marrel, Donald L. Patrick, Eric Van Ganse, Long-Term Treatment Acceptance, The Patient: Patient-Centered Outcomes Research, 10.2165/11631340-000000000-00000, 5, 4, (239-249), (2012).
- Claire Marant, Juliette Longin, Rémi Gauchoux, Benoit Arnould, Céderic Spizak, Alexia Marrel, Donald L. Patrick, Eric Van Ganse, Long-Term Treatment Acceptance, The Patient: Patient-Centered Outcomes Research, 10.1007/BF03262496, 5, 4, (239-249), (2012).
- Young-Ran Yeun, Systematic Review of Research on Adherence among Hemodialysis Patients in Korea, Journal of the Korea Academia-Industrial cooperation Society, 10.5762/KAIS.2012.13.12.5993, 13, 12, (5993-6000), (2012).
- Barbara U. Kadi, August Ruhs, Henriette Löffler-Stastka, An den Grenzen der DisziplinAt the limits of discipline, neuropsychiatrie, 10.1007/s40211-012-0029-3, 26, 4, (179-186), (2012).
- Georgios Efstathiou, Evridiki Papastavrou, Vasilios Raftopoulos, Anastasios Merkouris, Factors influencing nurses' compliance with Standard Precautions in order to avoid occupational exposure to microorganisms: A focus group study, BMC Nursing, 10.1186/1472-6955-10-1, 10, 1, (2011).
- Cynthia D Rothenberger, Chronic Illness Self‐Management in prediabetes: a concept analysis, Journal of Nursing and Healthcare of Chronic Illness, 10.1111/j.1752-9824.2011.01092.x, 3, 2, (77-86), (2011).
- Katrina Linehan, Mary Kilker OSullivan, The non-surgical management of Congenital Talipes Equino Varus (CTEV) in the first year of life: An Irish perspective, International Journal of Orthopaedic and Trauma Nursing, 10.1016/j.ijotn.2010.09.002, 15, 2, (71-75), (2011).
- Amanda I. Gillespie, Katherine Verdolini Abbott, The influence of clinical terminology on self-efficacy for voice, Logopedics Phoniatrics Vocology, 10.3109/14015439.2010.539259, 36, 3, (91-99), (2010).
- Patricia Cronin, F Ryan, M Coughlan, Concept analysis in healthcare research, International Journal of Therapy and Rehabilitation, 10.12968/ijtr.2010.17.2.46331, 17, 2, (62-68), (2010).
- Véronique Paradis, Sylvie Cossette, Nancy Frasure-Smith, Sonia Heppell, Marie-Claude Guertin, The Efficacy of a Motivational Nursing Intervention Based on the Stages of Change on Self-care in Heart Failure Patients, The Journal of Cardiovascular Nursing, 10.1097/JCN.0b013e3181c52497, 25, 2, (130-141), (2010).
- Claus Møldrup, Jonathan Stein, Birthe Søndergaard, “Patients don’t lie”; a view on adherence in asthma, Pharmacy World & Science, 10.1007/s11096-010-9439-0, 32, 6, (795-798), (2010).
- Hans-Jörg Znoj, Nadine Messerli-Burgy, Simone Tschopp, Rainer Weber, Lisanne Christen, Stephan Christen, Klaus Grawe, Psychotherapeutic process of cognitive–behavioral intervention in HIV-infected persons: Results from a controlled, randomized prospective clinical trial, Psychotherapy Research, 10.1080/10503300903246663, 20, 2, (203-213), (2009).
- Allison F. Williams, Elizabeth Manias, Rowan Walker, The role of irrational thought in medicine adherence: people with diabetic kidney disease, Journal of Advanced Nursing, 10.1111/j.1365-2648.2009.05077.x, 65, 10, (2108-2117), (2009).
- Craig Duncan, Julie Duff Cloutier, P.H. Bailey, In response to: Risjord M. (2009) Rethinking concept analysis. Journal of Advanced Nursing 65(3), 684–691., Journal of Advanced Nursing, 10.1111/j.1365-2648.2009.05076.x, 65, 9, (1985-1986), (2009).
- Thomas M Maddox, P Michael Ho, Medication adherence and the patient with coronary artery disease: challenges for the practitioner, Current Opinion in Cardiology, 10.1097/HCO.0b013e32832ed62d, 24, 5, (468-472), (2009).




